The Role of Natural Products in Drug Discovery and Development against Neglected Tropical Diseases

Natural Products as Leads in Schistosome Drug Discovery

(2015) Bruno Neves et al.   MOLECULES

Repurposing Auranofin as a Lead Candidate for Treatment of Lymphatic Filariasis and Onchocerciasis

(2015) Christina A. Bulman et al.   PLoS Neglected Tropical Diseases

Anthelmintic Activity In Vivo of Epiisopiloturine against Juvenile and Adult Worms of Schistosoma mansoni

(2015) Maria A. Guimarães et al.   PLoS Neglected Tropical Diseases

Further Sesquiterpene Lactones from Viguiera robusta and the Potential Anti-Inflammatory Activity of a Heliangolide: Inhibition of Human Neutrophil Elastase Release

(2015) Nilton S. Arakawa et al.   ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES

Recent Approaches to Chemical Discovery and Development Against Malaria and the Neglected Tropical Diseases Human African Trypanosomiasis and Schistosomiasis

(2014) Mathew Njoroge et al.   CHEMICAL REVIEWS

Human schistosomiasis

(2014) Daniel G Colley et al.   LANCET

Phytol, a Diterpene Alcohol from Chlorophyll, as a Drug against Neglected Tropical Disease Schistosomiasis Mansoni

(2014) Josué de Moraes et al.   PLoS Neglected Tropical Diseases

Orally Active Antischistosomal Early Leads Identified from the Open Access Malaria Box

(2014) Katrin Ingram-Sieber et al.   PLoS Neglected Tropical Diseases

In SilicoPrediction and Experimental Evaluation of Furanoheliangolide Sesquiterpene Lactones as Potent Agents against Trypanosoma brucei rhodesiense

(2013) Thomas J. Schmidt et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Natural product based leads to fight against leishmaniasis

(2013) Nisha Singh et al.   BIOORGANIC & MEDICINAL CHEMISTRY

In Vitro Synergistic Interaction Between Amide Piplartine and Antimicrobial Peptide Dermaseptin Against Schistosoma mansoni Schistosomula and Adult Worms

(2013) J. de Moraes et al.   CURRENT MEDICINAL CHEMISTRY

Natural sesquiterpene lactones as inhibitors of Myb-dependent gene expression: Structure–activity relationships

(2013) Caroline Schomburg et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Natural Products as a Source for Treating Neglected Parasitic Diseases

(2013) Dieudonné Ndjonka et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Discovery of a New Class of Natural Product-Inspired Quinazolinone Hybrid as Potent Antileishmanial agents

(2013) Moni Sharma et al.   JOURNAL OF MEDICINAL CHEMISTRY

Natural and Semisynthetic Analogues of Manadoperoxide B Reveal New Structural Requirements for Trypanocidal Activity

(2013) Giuseppina Chianese et al.   Marine Drugs

Bioactive natural products derived from the Central African flora against neglected tropical diseases and HIV

(2013) Denis Zofou et al.   NATURAL PRODUCT REPORTS

Antischistosomal Activities of Mefloquine-Related Arylmethanols

(2012) Katrin Ingram et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Leishmanicidal activities and cytotoxicities of bisnaphthoquinone analogues and naphthol derivatives from Burman Diospyros burmanica

(2012) Kanami Mori-Yasumoto et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Recent Advances in the Medicinal Chemistry of Aurones

(2012) R. Haudecoeur et al.   CURRENT MEDICINAL CHEMISTRY

The Potential of Secondary Metabolites from Plants as Drugs or Leads Against Protozoan Neglected Diseases - Part I

(2012) T.J. Schmidt et al.   CURRENT MEDICINAL CHEMISTRY

The Potential of Secondary Metabolites from Plants as Drugs or Leads Against Protozoan Neglected Diseases - Part II

(2012) T.J. Schmidt et al.   CURRENT MEDICINAL CHEMISTRY

Antimalarials in the Treatment of Schistosomiasis

(2012) J Keiser   CURRENT PHARMACEUTICAL DESIGN

Overview of the therapeutic potential of piplartine (piperlongumine)

(2012) Daniel P. Bezerra et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Antifilarial activity of marine sponge Haliclona oculata against experimental Brugia malayi infection

(2012) Jyoti Gupta et al.   EXPERIMENTAL PARASITOLOGY

Schistosoma mansoni: In vitro schistosomicidal activity and tegumental alterations induced by piplartine on schistosomula

(2012) Josué de Moraes et al.   EXPERIMENTAL PARASITOLOGY

Identification of Th1-responsive leishmanial excretory–secretory antigens (LESAs)

(2012) Jalaj K. Gour et al.   EXPERIMENTAL PARASITOLOGY

Differentiation of Refined and Virgin Edible Oils by Means of the trans- and cis-Phytol Isomer Distribution

(2012) Walter Vetter et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Identification of Antischistosomal Leads by Evaluating Bridged 1,2,4,5-Tetraoxanes, Alphaperoxides, and Tricyclic Monoperoxides

(2012) Katrin Ingram et al.   JOURNAL OF MEDICINAL CHEMISTRY

Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010

(2012) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Manadoperoxides, a new class of potent antitrypanosomal agents of marine origin

(2012) Giuseppina Chianese et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Sterols with antileishmanial activity isolated from the roots of Pentalinon andrieuxii

(2012) Li Pan et al.   PHYTOCHEMISTRY

Effects of (−) mammea A/BB isolated from Calophyllum brasiliense leaves and derivatives on mitochondrial membrane of Leishmania amazonensis

(2012) M.A. Brenzan et al.   PHYTOMEDICINE

Antileishmanial natural prenylated anthranoids

(2012) B Lenta et al.   PLANTA MEDICA

The global burden of neglected tropical diseases

(2012) A. Fenwick   PUBLIC HEALTH

An alternative total synthesis of solamargine

(2012) GuoHua Wei et al.   Science China-Chemistry

Leishmaniasis: Current status of available drugs and new potential drug targets

(2012) Nisha Singh et al.   Asian Pacific Journal of Tropical Medicine

Identification of plumbagin and sanguinarine as effective chemotherapeutic agents for treatment of schistosomiasis

(2012) Si-Ming Zhang et al.   International Journal for Parasitology-Drugs and Drug Resistance

Phytol-derived novel isoprenoid immunostimulants

(2012) Roshni Roy Chowdhury   Frontiers in Immunology

Antitrypanosomal sesquiterpene lactones from Saussurea costus

(2011) Tasqiah Julianti et al.   FITOTERAPIA

Interactions of mefloquine with praziquantel in the Schistosoma mansoni mouse model and in vitro

(2011) J. Keiser et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Comparison of short-course multidrug treatment with standard therapy for visceral leishmaniasis in India: an open-label, non-inferiority, randomised controlled trial

(2011) Shyam Sundar et al.   LANCET

Selective killing of cancer cells by a small molecule targeting the stress response to ROS

(2011) Lakshmi Raj et al.   NATURE

Gedunin and photogedunin of Xylocarpus granatum possess antifilarial activity against human lymphatic filarial parasite Brugia malayi in experimental rodent host

(2011) Sweta Misra et al.   PARASITOLOGY RESEARCH

Antischistosomal activity of ginger (Zingiber officinale) against Schistosoma mansoni harbored in C57 mice

(2011) Osama M. S. Mostafa et al.   PARASITOLOGY RESEARCH

Ultrastructural study on the morphological changes to male worms of Schistosoma mansoni after in vitro exposure to allicin

(2011) Caliandra Maria Bezerra Luna Lima et al.   Revista da Sociedade Brasileira de Medicina Tropical

Therapeutic Effects of Allium sativum and Allium cepa in Schistosoma mansoni experimental infection

(2011) Mona Mohamed Mantawy et al.   REVISTA DO INSTITUTO DE MEDICINA TROPICAL DE SAO PAULO

Examining the Relationship between Urogenital Schistosomiasis and HIV Infection

(2011) Pamela Sabina Mbabazi et al.   PLoS Neglected Tropical Diseases

Biomimetic Oxidation of Piperine and Piplartine Catalyzed by Iron(III) and Manganese(III) Porphyrins

(2010) Estela Hanauer Schaab et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Neglected tropical diseases

(2010) N. Feasey et al.   BRITISH MEDICAL BULLETIN

Quinolines and structurally related heterocycles as antimalarials

(2010) Kirandeep Kaur et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Schistosoma mansoni: In vitro schistosomicidal activity of piplartine

(2010) Josué de Moraes et al.   EXPERIMENTAL PARASITOLOGY

Schistosoma mansoni: Schistosomicidal effect of mefloquine and primaquine in vitro

(2010) M.C. Holtfreter et al.   EXPERIMENTAL PARASITOLOGY

Antiprotozoal Steroidal Saponins from the Marine SpongePandaros acanthifolium

(2010) Erik L. Regalado et al.   JOURNAL OF NATURAL PRODUCTS

Bromopyrrole Alkaloids as Lead Compounds against Protozoan Parasites

(2010) Fernando Scala et al.   Marine Drugs

Anti-Parasitic Compounds from Streptomyces sp. Strains Isolated from Mediterranean Sponges

(2010) Sheila Marie Pimentel-Elardo et al.   Marine Drugs

Effect of mefloquine administered orally at single, multiple, or combined with artemether, artesunate, or praziquantel in treatment of mice infected with Schistosoma japonicum

(2010) Shu-hua Xiao et al.   PARASITOLOGY RESEARCH

The Tegument of the Human Parasitic Worm Schistosoma mansoni as an Excretory Organ: The Surface Aquaporin SmAQP Is a Lactate Transporter

(2010) Zahra Faghiri et al.   PLoS One

Novel drug designing rationale against Brugia malayi microfilariae using herbal extracts

(2010) RD Sharma et al.   Asian Pacific Journal of Tropical Medicine

Drug Resistance in Visceral Leishmaniasis

(2009) Helena C. Maltezou   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Human African trypanosomiasis

(2009) Reto Brun et al.   LANCET

Fighting Against Leishmaniasis: Search of Alkaloids as Future True Potential Anti-Leishmanial Agents

(2009) Bhuwan Mishra et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Screening of Agelasine D and Analogs for Inhibitory Activity against Pathogenic Protozoa; Identification of Hits for Visceral Leishmaniasis and Chagas Disease

(2009) Anders Vik et al.   MOLECULES

Morphological effects and tegumental alterations induced by mefloquine on schistosomula and adult flukes of Schistosoma mansoni

(2009) T. MANNECK et al.   PARASITOLOGY

Schistosomiasis and neglected tropical diseases: towards integrated and sustainable control and a word of caution

(2009) J. UTZINGER et al.   PARASITOLOGY

In vitro schistosomicidal effects of some phloroglucinol derivatives from Dryopteris species against Schistosoma mansoni adult worms

(2009) Lizandra G. Magalhães et al.   PARASITOLOGY RESEARCH

In vitro antifilarial activity of glutathione S-transferase inhibitors

(2009) Lakshmy Srinivasan et al.   PARASITOLOGY RESEARCH

In vitro and in vivo antifilarial potential of marine sponge, Haliclona exigua (Kirkpatrick), against human lymphatic filarial parasite Brugia malayi

(2009) Vijai Lakshmi et al.   PARASITOLOGY RESEARCH

Leishmanicidal effect of LLD-3 (1), a nor-triterpene isolated from Lophanthera lactescens

(2009) M.G.M. Danelli et al.   PHYTOCHEMISTRY

The antitumoral, trypanocidal and antileishmanial activities of extract and alkaloids isolated from Duguetia furfuracea

(2009) D.B. da Silva et al.   PHYTOMEDICINE

The Antiprotozoal Activity of Sixteen Asteraceae Species Native to Sudan and Bioactivity-Guided Isolation of Xanthanolides fromXanthium brasilicum

(2009) Amal Nour et al.   PLANTA MEDICA

Amphotericin B: side effects and toxicity

(2009) Rafael Laniado-Laborín et al.   REVISTA IBEROAMERICANA DE MICOLOGIA

Mefloquine—An Aminoalcohol with Promising Antischistosomal Properties in Mice

(2009) Jennifer Keiser et al.   PLoS Neglected Tropical Diseases

Neglected Tropical Diseases in Sub-Saharan Africa: Review of Their Prevalence, Distribution, and Disease Burden

(2009) Peter J. Hotez et al.   PLoS Neglected Tropical Diseases

Natural Products as a Robust Source of New Drugs and Drug Leads: Past Successes and Present Day Issues

(2008) Gilbert M. Rishton   AMERICAN JOURNAL OF CARDIOLOGY

Trypanocidal and Leishmanicidal Activities of Sesquiterpene Lactones from Ambrosia tenuifolia Sprengel (Asteraceae)

(2008) V. P. Sulsen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Curcumin: From ancient medicine to current clinical trials

(2008) H. Hatcher et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The impact of natural products upon modern drug discovery

(2008) A Ganesan   CURRENT OPINION IN CHEMICAL BIOLOGY

Natural Products for Neglected Diseases: A Review

(2008) Jean-Robert Ioset   CURRENT ORGANIC CHEMISTRY

Antifilarial Lead Molecules Isolated from Trachyspermum ammi

(2008) Nisha Mathew et al.   MOLECULES

Evaluation of the genotoxicity of piplartine, an alkamide of Piper tuberculatum, in yeast and mammalian V79 cells

(2008) Daniel Pereira Bezerra et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Natural products to drugs: natural product-derived compounds in clinical trials

(2008) Mark S. Butler   NATURAL PRODUCT REPORTS

In vitro schistosomicidal activity of curcumin against Schistosoma mansoni adult worms

(2008) Lizandra G. Magalhães et al.   PARASITOLOGY RESEARCH

Eliminating Human African Trypanosomiasis: Where Do We Stand and What Comes Next?

(2008) Pere P Simarro et al.   PLOS MEDICINE

Complexities of Assessing the Disease Burden Attributable to Leishmaniasis

(2008) Caryn Bern et al.   PLoS Neglected Tropical Diseases

Mucosal leishmaniasis

(2007) Valdir Sabbaga Amato et al.   ACTA TROPICA