Novel roles of amyloid-beta precursor protein metabolites in fragile X syndrome and autism

Finding novel distinctions between the sAPPα-mediated anabolic biochemical pathways in Autism Spectrum Disorder and Fragile X Syndrome plasma and brain tissue

(2016) Balmiki Ray et al.   Scientific Reports

Intrinsic excitability changes induced by acute treatment of hippocampal CA1 pyramidal neurons with exogenous amyloid β peptide

(2015) Francesco Tamagnini et al.   HIPPOCAMPUS

Fragile X disappointments upset autism ambitions

(2015) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

Dysregulated ADAM10-Mediated Processing of APP during a Critical Time Window Leads to Synaptic Deficits in Fragile X Syndrome

(2015) Emanuela Pasciuto et al.   NEURON

Seizures in Alzheimer’s disease

(2015) H.A. Born   NEUROSCIENCE

Neuronal nucleus and cytoplasm volume deficit in children with autism and volume increase in adolescents and adults

(2015) Jerzy Wegiel et al.   Acta Neuropathologica Communications

Acute function of secreted amyloid precursor protein fragment APPsα in synaptic plasticity

(2014) Meike Hick et al.   ACTA NEUROPATHOLOGICA

EEG abnormalities and seizures in genetically diagnosed Fragile X syndrome

(2014) Takijah T. Heard et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Genetic Suppression of Transgenic APP Rescues Hypersynchronous Network Activity in a Mouse Model of Alzeimer's Disease

(2014) H. A. Born et al.   JOURNAL OF NEUROSCIENCE

TACE/ADAM17 Is Essential for Oligodendrocyte Development and CNS Myelination

(2014) J. Palazuelos et al.   JOURNAL OF NEUROSCIENCE

Impact of acamprosate on plasma amyloid-β precursor protein in youth: A pilot analysis in fragile X syndrome-associated and idiopathic autism spectrum disorder suggests a pharmacodynamic protein marker

(2014) Craig A. Erickson et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Early Generalized Overgrowth in Autism Spectrum Disorder: Prevalence Rates, Gender Effects, and Clinical Outcomes

(2014) Daniel J. Campbell et al.   JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY

Altered expression of Alzheimer’s disease-related genes in the cerebellum of autistic patients: a model for disrupted brain connectome and therapy

(2014) F Zeidán-Chuliá et al.   Cell Death & Disease

Transcriptome analysis reveals dysregulation of innate immune response genes and neuronal activity-dependent genes in autism

(2014) Simone Gupta et al.   Nature Communications

BACE1 inhibitor drugs in clinical trials for Alzheimer’s disease

(2014) Robert Vassar   Alzheimers Research & Therapy

Neuron-to-neuron wild-type Tau protein transfer through a trans-synaptic mechanism: relevance to sporadic tauopathies

(2014) Simon Dujardin et al.   Acta Neuropathologica Communications

Compared to What? Early Brain Overgrowth in Autism and the Perils of Population Norms

(2013) Armin Raznahan et al.   BIOLOGICAL PSYCHIATRY

Epilepsy drives autism in neurodevelopmental disorders

(2013) Randi J Hagerman   DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

GFAP expression and social deficits in transgenic mice overexpressing human sAPPα

(2013) Antoinette R. Bailey et al.   GLIA

Delayed myelination in a mouse model of fragile X syndrome

(2013) L. K. K. Pacey et al.   HUMAN MOLECULAR GENETICS

Outcome Measures for Clinical Trials in Fragile X Syndrome

(2013) Elizabeth Berry-Kravis et al.   JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS

Activity-Induced Convergence of APP and BACE-1 in Acidic Microdomains via an Endocytosis-Dependent Pathway

(2013) Utpal Das et al.   NEURON

Enhancement of long-term depression by soluble amyloid β protein in rat hippocampus is mediated by metabotropic glutamate receptor and involves activation of p38MAPK, STEP and caspase-3

(2013) X. Chen et al.   NEUROSCIENCE

Autism as early neurodevelopmental disorder: evidence for an sAPPα-mediated anabolic pathway

(2013) Debomoy K. Lahiri et al.   Frontiers in Cellular Neuroscience

Impairment of fragile X mental retardation protein-metabotropic glutamate receptor 5 signaling and its downstream cognates ras-related C3 botulinum toxin substrate 1, amyloid beta A4 precursor protein, striatal-enriched protein tyrosine phosphatase, and homer 1, in autism: a postmortem study in cerebellar vermis and superior frontal cortex

(2013) S Fatemi et al.   Molecular Autism

A novel study on amyloid β peptide 40, 42 and 40/42 ratio in Saudi autistics

(2012) Laila Y Al- Ayadhi et al.   Behavioral and Brain Functions

Fragile X Syndrome

(2012) Yingratana McLennan et al.   CURRENT GENOMICS

Understanding relationships between autism, intelligence, and epilepsy: a cross-disorder approach

(2012) AGNIES M van EEGHEN et al.   DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

Biochemical Inhibition of the Acetyltransferases ATase1 and ATase2 Reduces β-Secretase (BACE1) Levels and Aβ Generation

(2012) Yun Ding et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid precursor protein (APP) regulates synaptic structure and function

(2012) Sheue-Houy Tyan et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

What’s hAPPening at synapses? The role of amyloid β-protein precursor and β-amyloid in neurological disorders

(2012) C J Westmark   MOLECULAR PSYCHIATRY

Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations

(2012) Brian J. O’Roak et al.   NATURE

De Novo Gene Disruptions in Children on the Autistic Spectrum

(2012) Ivan Iossifov et al.   NEURON

Abnormal Intracellular Accumulation and Extracellular Aβ Deposition in Idiopathic and Dup15q11.2-q13 Autism Spectrum Disorders

(2012) Jerzy Wegiel et al.   PLoS One

Prevalence of Autism Spectrum Disorders in a Total Population Sample

(2011) Young Shin Kim et al.   AMERICAN JOURNAL OF PSYCHIATRY

FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism

(2011) Jennifer C. Darnell et al.   CELL

What Can We Learn about Autism from Studying Fragile X Syndrome?

(2011) Dejan B. Budimirovic et al.   DEVELOPMENTAL NEUROSCIENCE

Aberrant T-lymphocyte development and function in mice overexpressing human soluble amyloid precursor protein-α: implications for autism

(2011) Antoinette R. Bailey et al.   FASEB JOURNAL

Autism in Fragile X Syndrome: A Category Mistake?

(2011) Scott S. Hall et al.   JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY

Drugs: A tangled web of targets

(2011) Lauren Gravitz   NATURE

The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer’s disease

(2011) Sergio T. Ferreira et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Increased Secreted Amyloid Precursor Protein-α (sAPPα) in Severe Autism: Proposal of a Specific, Anabolic Pathway and Putative Biomarker

(2011) Balmiki Ray et al.   PLoS One

Angelman Syndrome Protein UBE3A Interacts with Primary Microcephaly Protein ASPM, Localizes to Centrosomes and Regulates Chromosome Segregation

(2011) Pooja Singhmar et al.   PLoS One

Reversal of Fragile X Phenotypes by Manipulation of AβPP/Aβ Levels in Fmr1KO Mice

(2011) Cara J. Westmark et al.   PLoS One

Dysregulation of fragile × mental retardation protein and metabotropic glutamate receptor 5 in superior frontal cortex of individuals with autism: a postmortem brain study

(2011) S Hossein Fatemi et al.   Molecular Autism

Early Oligodendrocyte/Myelin Pathology in Alzheimer's Disease Mice Constitutes a Novel Therapeutic Target

(2010) Maya K. Desai et al.   AMERICAN JOURNAL OF PATHOLOGY

β-Secretase inhibitor GRL-8234 rescues age-related cognitive decline in APP transgenic mice

(2010) Wan-Pin Chang et al.   FASEB JOURNAL

hnRNP C promotes APP translation by competing with FMRP for APP mRNA recruitment to P bodies

(2010) Eun Kyung Lee et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

In vivo brain anatomy of adult males with Fragile X syndrome: An MRI study

(2010) Brian P. Hallahan et al.   NEUROIMAGE

Deleterious Effects of Amyloid β Oligomers Acting as an Extracellular Scaffold for mGluR5

(2010) Marianne Renner et al.   NEURON

Region-specific alterations in brain development in one- to three-year-old boys with fragile X syndrome

(2010) F. Hoeft et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amygdala Enlargement in Toddlers with Autism Related to Severity of Social and Communication Impairments

(2009) Cynthia Mills Schumann et al.   BIOLOGICAL PSYCHIATRY

Teasing apart the heterogeneity of autism: Same behavior, different brains in toddlers with fragile X syndrome and autism

(2009) Heather Cody Hazlett et al.   Journal of Neurodevelopmental Disorders

The LEARn model: an epigenetic explanation for idiopathic neurobiological diseases

(2009) D K Lahiri et al.   MOLECULAR PSYCHIATRY

Epilepsy in Autism is Associated with Intellectual Disability and Gender: Evidence from a Meta-Analysis

(2008) Claire Amiet et al.   BIOLOGICAL PSYCHIATRY

Two Endoplasmic Reticulum (ER)/ER Golgi Intermediate Compartment-based Lysine Acetyltransferases Post-translationally Regulate BACE1 Levels

(2008) Mi Hee Ko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Behavioural and cognitive phenotypes in idiopathic autism versus autism associated with fragile X syndrome

(2008) Cheryl Dissanayake et al.   JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY

Rescue of behavioral phenotype and neuronal protrusion morphology in Fmr1 KO mice

(2008) Femke M.S. de Vrij et al.   NEUROBIOLOGY OF DISEASE

Peripheral A  subspecies as risk biomarkers of Alzheimer's disease

(2008) N. Schupf et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuroanatomy of fragile X syndrome is associated with aberrant behavior and the fragile X mental retardation protein (FMRP)

(2007) Doron Gothelf et al.   ANNALS OF NEUROLOGY

Potent memapsin 2 (β-secretase) inhibitors: Design, synthesis, protein-ligand X-ray structure, and in vivo evaluation

(2007) Arun K. Ghosh et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS