Finding novel distinctions between the sAPPα-mediated anabolic biochemical pathways in Autism Spectrum Disorder and Fragile X Syndrome plasma and brain tissue

Identification and validation of biomarkers for autism spectrum disorders

(2016) Eva Loth et al.   NATURE REVIEWS DRUG DISCOVERY

Mavoglurant in fragile X syndrome: Results of two randomized, double-blind, placebo-controlled trials

(2016) Elizabeth Berry-Kravis et al.   Science Translational Medicine

A Search for Blood Biomarkers for Autism: Peptoids

(2016) Sayed Zaman et al.   Scientific Reports

B-71Enlarged Brain Volume and Elevated Secreted Amyloid Precursor Protein-Alpha (sAPP) Levels in Autism are Consistent with sAPP Mediated Anabolic Pathway and Macrocephaly

(2015) D Sokol et al.   ARCHIVES OF CLINICAL NEUROPSYCHOLOGY

2014 Alzheimer's disease facts and figures

(2014)   Alzheimers & Dementia

TACE/ADAM17 Is Essential for Oligodendrocyte Development and CNS Myelination

(2014) J. Palazuelos et al.   JOURNAL OF NEUROSCIENCE

Impact of acamprosate on plasma amyloid-β precursor protein in youth: A pilot analysis in fragile X syndrome-associated and idiopathic autism spectrum disorder suggests a pharmacodynamic protein marker

(2014) Craig A. Erickson et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Increased BDNF expression in fetal brain in the valproic acid model of autism

(2014) Luis E.F. Almeida et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Unraveling the Mechanisms Responsible for the Comorbidity between Metabolic Syndrome and Mental Health Disorders

(2014) Elizabeth K. Nousen et al.   NEUROENDOCRINOLOGY

Loss of mTOR-Dependent Macroautophagy Causes Autistic-like Synaptic Pruning Deficits

(2014) Guomei Tang et al.   NEURON

Sorting the Role of SORLA in Alzheimer's Disease

(2014) V. Buggia-Prevot et al.   Science Translational Medicine

Time-dependent changes in gene expression induced by secreted amyloid precursor protein-alpha in the rat hippocampus

(2013) Margaret M Ryan et al.   BMC GENOMICS

Modulation of Rack-1/PKCβII Signalling By Soluble AβPPα in SH-SY5Y Cells

(2013) Erica Buoso et al.   Current Alzheimer Research

Pioglitazone improves glucose metabolism and modulates skeletal muscle TIMP-3–TACE dyad in type 2 diabetes mellitus: a randomised, double-blind, placebo-controlled, mechanistic study

(2013) Devjit Tripathy et al.   DIABETOLOGIA

The Fragile X Protein binds mRNAs involved in cancer progression and modulates metastasis formation

(2013) Rossella Lucá et al.   EMBO Molecular Medicine

GFAP expression and social deficits in transgenic mice overexpressing human sAPPα

(2013) Antoinette R. Bailey et al.   GLIA

MicroRNA-339-5p Down-regulates Protein Expression of β-Site Amyloid Precursor Protein-Cleaving Enzyme 1 (BACE1) in Human Primary Brain Cultures and Is Reduced in Brain Tissue Specimens of Alzheimer Disease Subjects

(2013) Justin M. Long et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activity-dependent phosphorylation of MeCP2 threonine 308 regulates interaction with NCoR

(2013) Daniel H. Ebert et al.   NATURE

Activity-dependent neuronal signalling and autism spectrum disorder

(2013) Daniel H. Ebert et al.   NATURE

Overexpression of Down syndrome cell adhesion molecule impairs precise synaptic targeting

(2013) Vedrana Cvetkovska et al.   NATURE NEUROSCIENCE

Drug discovery for autism spectrum disorder: challenges and opportunities

(2013) Anirvan Ghosh et al.   NATURE REVIEWS DRUG DISCOVERY

Neuron-specific chromatin remodeling: A missing link in epigenetic mechanisms underlying synaptic plasticity, memory, and intellectual disability disorders

(2013) Annie Vogel-Ciernia et al.   NEUROPHARMACOLOGY

Soluble Alpha-APP (sAPPalpha) Regulates CDK5 Expression and Activity in Neurons

(2013) Daniela Hartl et al.   PLoS One

Novel 5′ Untranslated Region Directed Blockers of Iron-Regulatory Protein-1 Dependent Amyloid Precursor Protein Translation: Implications for Down Syndrome and Alzheimer's Disease

(2013) Sanghamitra Bandyopadhyay et al.   PLoS One

APP Regulates NGF Receptor Trafficking and NGF-Mediated Neuronal Differentiation and Survival

(2013) Yun-wu Zhang et al.   PLoS One

Soluble β-amyloid Precursor Protein Alpha Binds to p75 Neurotrophin Receptor to Promote Neurite Outgrowth

(2013) Noriko Hasebe et al.   PLoS One

Autism as early neurodevelopmental disorder: evidence for an sAPPα-mediated anabolic pathway

(2013) Debomoy K. Lahiri et al.   Frontiers in Cellular Neuroscience

Physiological Functions of APP Family Proteins

(2013) U. C. Muller et al.   Cold Spring Harbor Perspectives in Medicine

A role for synaptic plasticity in the adolescent development of executive function

(2013) L D Selemon   Translational Psychiatry

Multiple Autism-Linked Genes Mediate Synapse Elimination via Proteasomal Degradation of a Synaptic Scaffold PSD-95

(2012) Nien-Pei Tsai et al.   CELL

Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations

(2012) Brian J. O’Roak et al.   NATURE

NMDA Receptor-Dependent Long-Term Potentiation and Long-Term Depression (LTP/LTD)

(2012) C. Luscher et al.   Cold Spring Harbor Perspectives in Biology

Fragile X Syndrome: The FMR1 CGG Repeat Distribution Among World Populations

(2011) Emmanuel Peprah   ANNALS OF HUMAN GENETICS

Early Brain Overgrowth in Autism Associated With an Increase in Cortical Surface Area Before Age 2 Years

(2011) Heather Cody Hazlett et al.   ARCHIVES OF GENERAL PSYCHIATRY

Elevated Transcription Factor Specificity Protein 1 in Autistic Brains Alters the Expression of Autism Candidate Genes

(2011) Ismail Thanseem et al.   BIOLOGICAL PSYCHIATRY

Aberrant T-lymphocyte development and function in mice overexpressing human soluble amyloid precursor protein-α: implications for autism

(2011) Antoinette R. Bailey et al.   FASEB JOURNAL

Wnt/ -Catenin Signaling Is an Essential and Direct Driver of Myelin Gene Expression and Myelinogenesis

(2011) M. Tawk et al.   JOURNAL OF NEUROSCIENCE

Autism in Fragile X Syndrome: A Category Mistake?

(2011) Scott S. Hall et al.   JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY

The conundrums of understanding genetic risks for autism spectrum disorders

(2011) Matthew W State et al.   NATURE NEUROSCIENCE

Autism, Alzheimer disease, and fragile X: APP, FMRP, and mGluR5 are molecular links

(2011) D. K. Sokol et al.   NEUROLOGY

The ε3 and ε4 Alleles of Human APOE Differentially Affect Tau Phosphorylation in Hyperinsulinemic and Pioglitazone Treated Mice

(2011) Alvina W. M. To et al.   PLoS One

Increased Secreted Amyloid Precursor Protein-α (sAPPα) in Severe Autism: Proposal of a Specific, Anabolic Pathway and Putative Biomarker

(2011) Balmiki Ray et al.   PLoS One

Reversal of Fragile X Phenotypes by Manipulation of AβPP/Aβ Levels in Fmr1KO Mice

(2011) Cara J. Westmark et al.   PLoS One

No association of polymorphisms in the CDK5, NDEL1, and LIS1 with autism in Chinese Han population

(2011) Lifang Wang et al.   PSYCHIATRY RESEARCH

Amygdala atrophy is prominent in early Alzheimer's disease and relates to symptom severity

(2011) Stéphane P. Poulin et al.   PSYCHIATRY RESEARCH-NEUROIMAGING

Dysregulation of fragile × mental retardation protein and metabotropic glutamate receptor 5 in superior frontal cortex of individuals with autism: a postmortem brain study

(2011) S Hossein Fatemi et al.   Molecular Autism

Beyond the signaling effect role of amyloid-β42 on the processing of APP, and its clinical implications

(2010) Debomoy K. Lahiri et al.   EXPERIMENTAL NEUROLOGY

Fragile X: Leading the way for targeted treatments in autism

(2010) Lulu W. Wang et al.   Neurotherapeutics

Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP

(2010) H. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Longitudinal Study of Amygdala Volume and Joint Attention in 2- to 4-Year-Old Children With Autism

(2009) Matthew W. Mosconi et al.   ARCHIVES OF GENERAL PSYCHIATRY

Amygdala Enlargement in Toddlers with Autism Related to Severity of Social and Communication Impairments

(2009) Cynthia Mills Schumann et al.   BIOLOGICAL PSYCHIATRY

Increased dendritic spine densities on cortical projection neurons in autism spectrum disorders

(2009) Jeffrey J. Hutsler et al.   BRAIN RESEARCH

Early white-matter abnormalities of the ventral frontostriatal pathway in fragile X syndrome

(2009) BRIAN W HAAS et al.   DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

Fragile X syndrome: from molecular genetics to therapy

(2009) C D'Hulst et al.   JOURNAL OF MEDICAL GENETICS

Teasing apart the heterogeneity of autism: Same behavior, different brains in toddlers with fragile X syndrome and autism

(2009) Heather Cody Hazlett et al.   Journal of Neurodevelopmental Disorders

Presynaptic and Postsynaptic Interaction of the Amyloid Precursor Protein Promotes Peripheral and Central Synaptogenesis

(2009) Z. Wang et al.   JOURNAL OF NEUROSCIENCE

Memantine lowers amyloid-β peptide levels in neuronal cultures and in APP/PS1 transgenic mice

(2009) George M. Alley et al.   JOURNAL OF NEUROSCIENCE RESEARCH

The PI3K-Akt-mTOR pathway regulates Aβ oligomer induced neuronal cell cycle events

(2009) Kiran Bhaskar et al.   Molecular Neurodegeneration

Memantine treatment decreases levels of secreted Alzheimer's amyloid precursor protein (APP) and amyloid beta (Aβ) peptide in the human neuroblastoma cells

(2009) Balmiki Ray et al.   NEUROSCIENCE LETTERS

MosaicFMR1 deletion causes fragile X syndrome and can lead to molecular misdiagnosis: A case report and review of the literature

(2008) Bradford Coffee et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Brain-derived neurotrophic factor and autism: maternal and infant peripheral blood levels in the Early Markers for Autism (EMA) study

(2008) Lisa A. Croen et al.   Autism Research

The Autistic Neuron: Troubled Translation?

(2008) Raymond J. Kelleher et al.   CELL

Diffusion Tensor Imaging of Frontal Lobe in Autism Spectrum Disorder

(2008) S. K. Sundaram et al.   CEREBRAL CORTEX

Behavioural and cognitive phenotypes in idiopathic autism versus autism associated with fragile X syndrome

(2008) Cheryl Dissanayake et al.   JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY

Transcription factor Sp1 dysregulation in Alzheimer's disease

(2008) Bruce A. Citron et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Activity-dependent regulation of inhibitory synapse development by Npas4

(2008) Yingxi Lin et al.   NATURE

Secreted APP regulates the function of full-length APP in neurite outgrowth through interaction with integrin beta1

(2008) Tracy L Young-Pearse et al.   Neural Development

Endogenous secreted amyloid precursor protein-α regulates hippocampal NMDA receptor function, long-term potentiation and spatial memory

(2008) Chanel J. Taylor et al.   NEUROBIOLOGY OF DISEASE

Neuroanatomy of fragile X syndrome is associated with aberrant behavior and the fragile X mental retardation protein (FMRP)

(2007) Doron Gothelf et al.   ANNALS OF NEUROLOGY