Elamipretide Topical Ophthalmic Solution for the Treatment of Subjects With Leber's Hereditary Optic Neuropathy: A Randomized Trial

Clinical outcomes of treatment with idebenone in Leber's hereditary optic neuropathy in the Netherlands: A national cohort study

(2022) Judith A. M. Everdingen et al.   ACTA OPHTHALMOLOGICA

Indirect Comparison of Lenadogene Nolparvovec Gene Therapy Versus Natural History in Patients with Leber Hereditary Optic Neuropathy Carrying the m.11778G>A MT-ND4 Mutation

(2022) Valerio Carelli et al.   Ophthalmology and Therapy

Efficacy and Safety of Intravitreal Gene Therapy for Leber Hereditary Optic Neuropathy Treated within 6 Months of Disease Onset

(2021) Nancy J. Newman et al.   OPHTHALMOLOGY

Natural history of patients with Leber hereditary optic neuropathy—results from the REALITY study

(2021) Patrick Yu-Wai-Man et al.   EYE

In vivo mitochondrial ATP production is improved in older adult skeletal muscle after a single dose of elamipretide in a randomized trial

(2021) Baback Roshanravan et al.   PLoS One

Effects of Elamipretide on Left Ventricular Function in Patients with Heart Failure with Reduced Ejection Fraction: The PROGRESS-HF Phase 2 Trial

(2020) Javed Butler et al.   JOURNAL OF CARDIAC FAILURE

A randomized crossover trial of elamipretide in adults with primary mitochondrial myopathy

(2020) Amel Karaa et al.   Journal of Cachexia Sarcopenia and Muscle

The mitochondria-targeted peptide SS-31 binds lipid bilayers and modulates surface electrostatics as a key component of its mechanism of action

(2020) Wayne Mitchell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Photopic negative response using a handheld mini-ganzfeld stimulator in healthy adults: normative values, intra- and inter-session variability

(2020) Adriana Berezovsky et al.   DOCUMENTA OPHTHALMOLOGICA

The cardiolipin-binding peptide elamipretide mitigates fragmentation of cristae networks following cardiac ischemia reperfusion in rats

(2020) Mitchell E. Allen et al.   Communications Biology

A phase 2/3 randomized clinical trial followed by an open-label extension to evaluate the effectiveness of elamipretide in Barth syndrome, a genetic disorder of mitochondrial cardiolipin metabolism

(2020) W. Reid Thompson et al.   GENETICS IN MEDICINE

Visual Outcomes in Leber Hereditary Optic Neuropathy Patients With the m.11778G>A (MTND4) Mitochondrial DNA Mutation

(2020) Nancy J. Newman et al.   JOURNAL OF NEURO-OPHTHALMOLOGY

Real-World Clinical Experience With Idebenone in the Treatment of Leber Hereditary Optic Neuropathy

(2020) Claudia B. Catarino et al.   JOURNAL OF NEURO-OPHTHALMOLOGY

Bilateral visual improvement with unilateral gene therapy injection for Leber hereditary optic neuropathy

(2020) Patrick Yu-Wai-Man et al.   Science Translational Medicine

Demographics of a Large International Population of Patients Affected by Leber’s Hereditary Optic Neuropathy

(2019) Lissa Poincenot et al.   OPHTHALMOLOGY

Randomized dose-escalation trial of elamipretide in adults with primary mitochondrial myopathy

(2018) Amel Karaa et al.   NEUROLOGY

Improving mitochondrial function with SS-31 reverses age-related redox stress and improves exercise tolerance in aged mice

(2018) Matthew D. Campbell et al.   FREE RADICAL BIOLOGY AND MEDICINE

Protection of mitochondria prevents high-fat diet–induced glomerulopathy and proximal tubular injury

(2016) Hazel H. Szeto et al.   KIDNEY INTERNATIONAL

Reduction of Early Reperfusion Injury With the Mitochondria-Targeting Peptide Bendavia

(2013) David A. Brown et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS

Mouse mtDNA mutant model of Leber hereditary optic neuropathy

(2012) C. S. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oestrogens ameliorate mitochondrial dysfunction in Leber’s hereditary optic neuropathy

(2010) Carla Giordano et al.   BRAIN

Inherited mitochondrial optic neuropathies

(2008) P Yu-Wai-Man et al.   JOURNAL OF MEDICAL GENETICS