METTL3 exacerbates insulin resistance in hepatocytes by regulating m6A modification of cytochrome P450 2B6

Adenosine N6-methylation upregulates the expression of human CYP2B6 by altering the chromatin status

(2022) Motoki Isono et al.   BIOCHEMICAL PHARMACOLOGY

Resveratrol Attenuates High-Fat Diet Induced Hepatic Lipid Homeostasis Disorder and Decreases m6A RNA Methylation

(2021) Jiamin Wu et al.   Frontiers in Pharmacology

Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia

(2021) Eliza Yankova et al.   NATURE

Metabolic-associated fatty liver disease and lipoprotein metabolism

(2021) Joerg Heeren et al.   Molecular Metabolism

Dual regulation of fatty acid synthase (FASN) expression by O-GlcNAc transferase (OGT) and mTOR pathway in proliferating liver cancer cells

(2021) Sadia Raab et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

METTL3-m6A-Rubicon axis inhibits autophagy in nonalcoholic fatty liver disease

(2021) Zishan Peng et al.   MOLECULAR THERAPY

Widespread remodeling of the m6A RNA-modification landscape by a viral regulator of RNA processing and export

(2021) Kalanghad Puthankalam Srinivas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism of noncoding RNA-associated N6-methyladenosine recognition by an RNA processing complex during IgH DNA recombination

(2021) Lekha Nair et al.   MOLECULAR CELL

Protective Effects of Sesamol against Liver Oxidative Stress and Inflammation in High-Fat Diet-Induced Hepatic Steatosis

(2021) Wenya Zheng et al.   Nutrients

N 6 ‐methyladenosine Reader Protein Ythdc2 Suppresses Liver Steatosis via Regulation of mRNA Stability of Lipogenic Genes

(2020) Bing Zhou et al.   HEPATOLOGY

Insulin-stimulated lipogenesis gets an epigenetic makeover

(2020) Clarence R. Manuel et al.   JOURNAL OF CLINICAL INVESTIGATION

Epitranscriptomics in liver disease: Basic concepts and therapeutic potential

(2020) Zhicong Zhao et al.   JOURNAL OF HEPATOLOGY

METTL3 is essential for postnatal development of brown adipose tissue and energy expenditure in mice

(2020) Yuqin Wang et al.   Nature Communications

Differential mechanisms regarding triclosan vs. bisphenol A and fluorene-9-bisphenol induced zebrafish lipid-metabolism disorders by RNA-Seq

(2020) Limei Sun et al.   CHEMOSPHERE

Linagliptin Ameliorates Hepatic Steatosis via Non-Canonical Mechanisms in Mice Treated with a Dual Inhibitor of Insulin Receptor and IGF-1 Receptor

(2020) Tomoko Okuyama et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Regulation of the cytochrome P450 epoxyeicosanoid pathway is associated with distinct histologic features in pediatric non-alcoholic fatty liver disease

(2020) Laura Kalveram et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Emerging Pharmacological Targets for the Treatment of Nonalcoholic Fatty Liver Disease, Insulin Resistance, and Type 2 Diabetes

(2019) Leigh Goedeke et al.   Annual Review of Pharmacology and Toxicology

The role of m6A RNA methylation in cancer

(2019) Ting Sun et al.   BIOMEDICINE & PHARMACOTHERAPY

Obesity, kidney dysfunction and hypertension: mechanistic links

(2019) John E. Hall et al.   Nature Reviews Nephrology

Activation of YAP attenuates hepatic damage and fibrosis in liver ischemia-reperfusion injury

(2019) Yuan Liu et al.   JOURNAL OF HEPATOLOGY

Role of the CLOCK protein in liver detoxification

(2019) Mengjing Zhao et al.   BRITISH JOURNAL OF PHARMACOLOGY

Reading, writing and erasing mRNA methylation

(2019) Sara Zaccara et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

METTL3 inhibits hepatic insulin sensitivity via N6-methyladenosine modification of Fasn mRNA and promoting fatty acid metabolism

(2019) Wei Xie et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Transient Focal Ischemia Significantly Alters the m 6 A Epitranscriptomic Tagging of RNAs in the Brain

(2019) Anil K. Chokkalla et al.   STROKE

Methylation of adenosine at the N6 position post-transcriptionally regulates hepatic P450s expression

(2019) Masataka Nakano et al.   BIOCHEMICAL PHARMACOLOGY

N 6-Methyladenosine modification of lincRNA 1281 is critically required for mESC differentiation potential

(2018) Dandan Yang et al.   NUCLEIC ACIDS RESEARCH

The Role of m6A/m-RNA Methylation in Stress Response Regulation

(2018) Mareen Engel et al.   NEURON

Reduced expression of Twist 1 is protective against insulin resistance of adipocytes and involves mitochondrial dysfunction

(2018) Sumei Lu et al.   Scientific Reports

Hepatic ceramides dissociate steatosis and insulin resistance in patients with non-alcoholic fatty liver disease

(2016) Panu K. Luukkonen et al.   JOURNAL OF HEPATOLOGY

N6-methyladenosine–encoded epitranscriptomics

(2016) Nian Liu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

N6-methyladenosine–encoded epitranscriptomics

(2016) Nian Liu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Effect of BI-1 on insulin resistance through regulation of CYP2E1

(2016) Geum-Hwa Lee et al.   Scientific Reports

mRNA m6A methylation downregulates adipogenesis in porcine adipocytes

(2015) Xinxia Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Insulin resistance alters hepatic ethanol metabolism: studies in mice and children with non-alcoholic fatty liver disease

(2015) Anna Janina Engstler et al.   GUT

Hematopoietic overexpression of Cyp27a1 reduces hepatic inflammation independently of 27-hydroxycholesterol levels in Ldlr−/− mice

(2015) Tim Hendrikx et al.   JOURNAL OF HEPATOLOGY

Hepatic STAMP2 alleviates high fat diet-induced hepatic steatosis and insulin resistance

(2015) Hye Y. Kim et al.   JOURNAL OF HEPATOLOGY

NAFLD: A multisystem disease

(2015) Christopher D. Byrne et al.   JOURNAL OF HEPATOLOGY

FTO-dependent function of N6-methyladenosine is involved in the hepatoprotective effects of betaine on adolescent mice

(2015) Jingqing Chen et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Human Receptor Activation by Aroclor 1260, a Polychlorinated Biphenyl Mixture

(2014) Banrida Wahlang et al.   TOXICOLOGICAL SCIENCES

Regulation of small RNA stability: methylation and beyond

(2012) Lijuan Ji et al.   CELL RESEARCH

Drug metabolizing enzyme induction pathways in experimental non-alcoholic steatohepatitis

(2008) Craig D. Fisher et al.   ARCHIVES OF TOXICOLOGY

Increased oxidative stress precedes the onset of high-fat diet–induced insulin resistance and obesity

(2008) Naoto Matsuzawa-Nagata et al.   METABOLISM-CLINICAL AND EXPERIMENTAL