Linagliptin Ameliorates Hepatic Steatosis via Non-Canonical Mechanisms in Mice Treated with a Dual Inhibitor of Insulin Receptor and IGF-1 Receptor

Luseogliflozin increases beta cell proliferation through humoral factors that activate an insulin receptor- and IGF-1 receptor-independent pathway

(2020) Jun Shirakawa et al.   DIABETOLOGIA

In Contrast to Dietary Restriction, Application of Resveratrol in Mice Does not Alter Mouse Major Urinary Protein Expression

(2020) Kathrin Pallauf et al.   Nutrients

Dipeptidyl peptidase-4 inhibition improves endothelial senescence by activating AMPK/SIRT1/Nrf2 signaling pathway

(2020) Zhihui Chen et al.   BIOCHEMICAL PHARMACOLOGY

Anagliptin ameliorates high glucose- induced endothelial dysfunction via suppression of NLRP3 inflammasome activation mediated by SIRT1

(2019) Tiechao Jiang et al.   MOLECULAR IMMUNOLOGY

Hepatocyte-secreted DPP4 in obesity promotes adipose inflammation and insulin resistance

(2018) Devram S. Ghorpade et al.   NATURE

Metabolic recovery of lipodystrophy, liver steatosis, and pancreatic β cell proliferation after the withdrawal of OSI-906

(2017) Kazuki Tajima et al.   Scientific Reports

Liver-specific loss of Perilipin 2 alleviates diet-induced hepatic steatosis, inflammation, and fibrosis

(2016) Charles P. Najt et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Lipodystrophy Due to Adipose Tissue–Specific Insulin Receptor Knockout Results in Progressive NAFLD

(2016) Samir Softic et al.   DIABETES

Perilipin-2 Deletion Impairs Hepatic Lipid Accumulation by Interfering with Sterol Regulatory Element-binding Protein (SREBP) Activation and Altering the Hepatic Lipidome

(2016) Andrew E. Libby et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DPP-4 inhibition improves early mortality, β cell function, and adipose tissue inflammation in db/db mice fed a diet containing sucrose and linoleic acid

(2016) Jun Shirakawa et al.   Diabetology & Metabolic Syndrome

NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus

(2015) Carles Cantó et al.   Cell Metabolism

Incretin-based therapies for the treatment of non-alcoholic fatty liver disease: A systematic review and meta-analysis

(2015) Laura J Carbone et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Hepatic insulin signalling is dispensable for suppression of glucose output by insulin in vivo

(2015) Paul M. Titchenell et al.   Nature Communications

FoxO1 integrates direct and indirect effects of insulin on hepatic glucose production and glucose utilization

(2015) InSug O-Sullivan et al.   Nature Communications

Liver disease and diabetes: Association, pathophysiology, and management

(2014) Hala Ahmadieh et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Effects of the Antitumor Drug OSI-906, a Dual Inhibitor of IGF-1 Receptor and Insulin Receptor, on the Glycemic Control, β-Cell Functions, and β-Cell Proliferation in Male Mice

(2014) Jun Shirakawa et al.   ENDOCRINOLOGY

Linagliptin Blocks Renal Damage in Type 1 Diabetic Rats by Suppressing Advanced Glycation End Products-Receptor Axis

(2014) S. Nakashima et al.   HORMONE AND METABOLIC RESEARCH

The Roles of Co-Chaperone CCRP/DNAJC7 in Cyp2b10 Gene Activation and Steatosis Development in Mouse Livers

(2014) Marumi Ohno et al.   PLoS One

SIRT1 and other sirtuins in metabolism

(2014) Hung-Chun Chang et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Potential of incretin-based therapies for non-alcoholic fatty liver disease

(2013) Susan L. Samson et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Linagliptin alleviates hepatic steatosis and inflammation in a mouse model of non-alcoholic steatohepatitis

(2013) Thomas Klein et al.   Medical Molecular Morphology

Insulin resistance and cancer: the role of insulin and IGFs

(2012) Sefirin Djiogue et al.   ENDOCRINE-RELATED CANCER

Effects of Liraglutide on β-Cell-Specific Glucokinase-Deficient Neonatal Mice

(2012) Jun Shirakawa et al.   ENDOCRINOLOGY

Linagliptin Improves Insulin Sensitivity and Hepatic Steatosis in Diet-Induced Obesity

(2012) Matthias Kern et al.   PLoS One

Diet-Induced Adipose Tissue Inflammation and Liver Steatosis Are Prevented by DPP-4 Inhibition in Diabetic Mice

(2011) J. Shirakawa et al.   DIABETES

Protective Effects of Dipeptidyl Peptidase-4 (DPP-4) Inhibitor against Increased β Cell Apoptosis Induced by Dietary Sucrose and Linoleic Acid in Mice with Diabetes

(2011) Jun Shirakawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Metabolism and Disposition of the Oral Dipeptidyl Peptidase-4 Inhibitor, Linagliptin, in Humans

(2010) S. Blech et al.   DRUG METABOLISM AND DISPOSITION

Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis

(2010) Herbert Tilg et al.   HEPATOLOGY

Insulin Receptor Isoforms and Insulin Receptor/Insulin-Like Growth Factor Receptor Hybrids in Physiology and Disease

(2009) Antonino Belfiore et al.   ENDOCRINE REVIEWS

Discovery of OSI-906: a selective and orally efficacious dual inhibitor of the IGF-1 receptor and insulin receptor

(2009) Mark J Mulvihill et al.   Future Medicinal Chemistry

Dynamic and differential regulation of proteins that coat lipid droplets infatty liver dystrophicmice

(2009) Angela M. Hall et al.   JOURNAL OF LIPID RESEARCH

Foxo1 integrates insulin signaling with mitochondrial function in the liver

(2009) Zhiyong Cheng et al.   NATURE MEDICINE

Phase Transfer Surfactant-Aided Trypsin Digestion for Membrane Proteome Analysis

(2008) Takeshi Masuda et al.   JOURNAL OF PROTEOME RESEARCH

Early drug development of inhibitors of the insulin-like growth factor-I receptor pathway: Lessons from the first clinical trials

(2008) J. Rodon et al.   MOLECULAR CANCER THERAPEUTICS