SARS-CoV-2 NSP1 induces mRNA cleavages on the ribosome

Structural insights into the activity regulation of full-length non-structural protein 1 from SARS-CoV-2

(2023) Ying Wang et al.   STRUCTURE

Biochemical and HDX Mass Spectral Characterization of the SARS-CoV-2 Nsp1 Protein

(2023) Nawneet Mishra et al.   Biochemistry

Correlated sequence signatures are present within the genomic 5′UTR RNA and NSP1 protein in coronaviruses

(2022) Piotr Sosnowski et al.   RNA

Viral and cellular translation during SARS‐CoV‐2 infection

(2022) Gilbert Eriani et al.   FEBS Open Bio

Dynamic competition between SARS-CoV-2 NSP1 and mRNA on the human ribosome inhibits translation initiation

(2021) Christopher P. Lapointe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genomic monitoring of SARS-CoV-2 uncovers an Nsp1 deletion variant that modulates type I interferon response

(2021) Jing-wen Lin et al.   Cell Host & Microbe

Mechanisms of Coronavirus Nsp1-Mediated Control of Host and Viral Gene Expression

(2021) Keisuke Nakagawa et al.   Cells

SARS-CoV-2 non-structural protein 1 inhibits the interferon response by causing depletion of key host signaling factors.

(2021) Anil Kumar et al.   JOURNAL OF VIROLOGY

SARS-CoV-2 uses a multipronged strategy to impede host protein synthesis

(2021) Yaara Finkel et al.   NATURE

Dissecting the early COVID-19 cases in Wuhan

(2021) Michael Worobey   SCIENCE

The N-terminal domain of SARS-CoV-2 nsp1 plays key roles in suppression of cellular gene expression and preservation of viral gene expression

(2021) Aaron S. Mendez et al.   Cell Reports

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2

(2020) Matthias Thoms et al.   SCIENCE

Activation and evasion of type I interferon responses by SARS-CoV-2

(2020) Xiaobo Lei et al.   Nature Communications

SARS-CoV-2 Disrupts Splicing, Translation, and Protein Trafficking to Suppress Host Defenses

(2020) Abhik K. Banerjee et al.   CELL

Emerging of a SARS-CoV-2 viral strain with a deletion in nsp1

(2020) Francesca Benedetti et al.   Journal of Translational Medicine

SARS-CoV-2 Nsp1 binds the ribosomal mRNA channel to inhibit translation

(2020) Katharina Schubert et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Secondary structure of the SARS-CoV-2 5’-UTR

(2020) Zhichao Miao et al.   RNA Biology

Structure of nonstructural protein 1 from SARS-CoV-2.

(2020) Lauren K. Clark et al.   JOURNAL OF VIROLOGY

Nonstructural Protein 1 of SARS-CoV-2 Is a Potent Pathogenicity Factor Redirecting Host Protein Synthesis Machinery toward Viral RNA

(2020) Shuai Yuan et al.   MOLECULAR CELL

The viral protein NSP1 acts as a ribosome gatekeeper for shutting down host translation and fostering SARS-CoV-2 translation

(2020) Antonin TIDU et al.   RNA

Structural characterization of nonstructural protein 1 from SARS-CoV-2

(2020) Cameron Semper et al.   iScience

The effect of adenine protonation on RNA phosphodiester backbone bond cleavage elucidated by deaza-nucleobase modifications and mass spectrometry

(2019) Elisabeth Fuchs et al.   NUCLEIC ACIDS RESEARCH

Severe Acute Respiratory Syndrome Coronavirus Protein nsp1 Is a Novel Eukaryotic Translation Inhibitor That Represses Multiple Steps of Translation Initiation

(2012) K. G. Lokugamage et al.   JOURNAL OF VIROLOGY

Severe Acute Respiratory Syndrome Coronavirus nsp1 Facilitates Efficient Propagation in Cells through a Specific Translational Shutoff of Host mRNA

(2012) T. Tanaka et al.   JOURNAL OF VIROLOGY

Cap-Assisted Internal Initiation of Translation of Histone H4

(2011) Franck Martin et al.   MOLECULAR CELL

SARS Coronavirus nsp1 Protein Induces Template-Dependent Endonucleolytic Cleavage of mRNAs: Viral mRNAs Are Resistant to nsp1-Induced RNA Cleavage

(2011) Cheng Huang et al.   PLoS Pathogens

A two-pronged strategy to suppress host protein synthesis by SARS coronavirus Nsp1 protein

(2009) Wataru Kamitani et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY