A ribonucleotide reductase inhibitor with deoxyribonucleoside-reversible cytotoxicity

Cladribine and Fludarabine Nucleotides Induce Distinct Hexamers Defining a Common Mode of Reversible RNR Inhibition

(2016) Somsinee Wisitpitthaya et al.   ACS Chemical Biology

Allosteric Inhibition of Human Ribonucleotide Reductase by dATP Entails the Stabilization of a Hexamer

(2016) Nozomi Ando et al.   BIOCHEMISTRY

Identification of Non-nucleoside Human Ribonucleotide Reductase Modulators

(2015) Md. Faiz Ahmad et al.   JOURNAL OF MEDICINAL CHEMISTRY

Ribonucleotide reductase and cancer: biological mechanisms and targeted therapies

(2014) Y Aye et al.   ONCOGENE

NCI-60 Whole Exome Sequencing and Pharmacological CellMiner Analyses

(2014) William C. Reinhold et al.   PLoS One

Hydroxyurea Induces a Hypersensitive Apoptotic Response in Mouse Embryonic Stem Cells Through p38-Dependent Acetylation of p53

(2014) Sun-Hee Heo et al.   STEM CELLS AND DEVELOPMENT

A Rare Combination of Ribonucleotide Reductases in the Social AmoebaDictyostelium discoideum

(2013) Mikael Crona et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CellMiner: A Web-Based Suite of Genomic and Pharmacologic Tools to Explore Transcript and Drug Patterns in the NCI-60 Cell Line Set

(2012) W. C. Reinhold et al.   CANCER RESEARCH

Ribonucleotide reductase small subunit M2 serves as a prognostic biomarker and predicts poor survival of colorectal cancers

(2012) Xiyong Liu et al.   CLINICAL SCIENCE

Pan-Pathway Based Interaction Profiling of FDA-Approved Nucleoside and Nucleobase Analogs with Enzymes of the Human Nucleotide Metabolism

(2012) Louise Egeblad et al.   PLoS One

Discovery of antimicrobial ribonucleotide reductase inhibitors by screening in microwell format

(2012) F. Tholander et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mammalian ribonucleotide reductase subunit p53R2 is required for mitochondrial DNA replication and DNA repair in quiescent cells

(2012) G. Pontarin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ribonucleotide Reductase Small Subunit M2B Prognoses Better Survival in Colorectal Cancer

(2011) X. Liu et al.   CANCER RESEARCH

DNA building blocks: keeping control of manufacture

(2011) Anders Hofer et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Long term cultured HL-60 cells are intrinsically resistant to Ara-C through high CDA activity

(2011) Jinqing Tang   Frontiers in Bioscience-Landmark

Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization

(2011) James Wesley Fairman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Clofarabine 5'-di and -triphosphates inhibit human ribonucleotide reductase by altering the quaternary structure of its large subunit

(2011) Y. Aye et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A phase II study of the antisense oligonucleotide GTI-2040 plus docetaxel and prednisone as first-line treatment in castration-resistant prostate cancer

(2010) Srikala S. Sridhar et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

The ribonucleotide reductase large subunit (RRM1) as a predictive factor in patients with cancer

(2010) Lars Petter Jordheim et al.   LANCET ONCOLOGY

Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles

(2010) Mark E. Davis et al.   NATURE

Phase II study of 3-AP Triapine in patients with recurrent or metastatic head and neck squamous cell carcinoma

(2009) C. M. Nutting et al.   ANNALS OF ONCOLOGY

Mechanism of Inactivation of Human Ribonucleotide Reductase with p53R2 by Gemcitabine 5′-Diphosphate

(2009) Jun Wang et al.   BIOCHEMISTRY

CellMiner: a relational database and query tool for the NCI-60 cancer cell lines

(2009) Uma T Shankavaram et al.   BMC GENOMICS

Hydroxyurea and hydroxamic acid derivatives as antitumor drugs

(2009) Nina Saban et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

A phase II trial of Triapine® (NSC# 663249) and gemcitabine as second line treatment of advanced non-small cell lung cancer: Eastern Cooperative Oncology Group Study 1503

(2009) Anne M. Traynor et al.   INVESTIGATIONAL NEW DRUGS

Hydroxyurea Induces Hydroxyl Radical-Mediated Cell Death in Escherichia coli

(2009) Bryan W. Davies et al.   MOLECULAR CELL

Targeted Delivery of Antisense Oligodeoxynucleotide by Transferrin Conjugated pH-Sensitive Lipopolyplex Nanoparticles: A Novel Oligonucleotide-Based Therapeutic Strategy in Acute Myeloid Leukemia

(2009) Yan Jin et al.   MOLECULAR PHARMACEUTICS

Oligomerization Status Directs Overall Activity Regulation of theEscherichia coliClass Ia Ribonucleotide Reductase

(2008) Reza Rofougaran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY