Heart failure-induced cognitive dysfunction is mediated by intracellular Ca2+ leak through ryanodine receptor type 2

Alzheimer's‐like signaling in brains of COVID‐19 patients

(2022) Steve Reiken et al.   Alzheimers & Dementia

A drug and ATP binding site in type 1 ryanodine receptor

(2022) Zephan Melville et al.   STRUCTURE

Structural analyses of human ryanodine receptor type 2 channels reveal the mechanisms for sudden cardiac death and treatment

(2022) Marco C. Miotto et al.   Science Advances

Targeting immunosuppression by TGF-β1 for cancer immunotherapy

(2021) Grégoire de Streel et al.   BIOCHEMICAL PHARMACOLOGY

Beta-blocker therapy and risk of vascular dementia: A population-based prospective study

(2020) H. Holm et al.   VASCULAR PHARMACOLOGY

Attention-enhancing effects of propranolol and synergistic effects with nicotine

(2020) Britta Hahn et al.   COGNITIVE AFFECTIVE & BEHAVIORAL NEUROSCIENCE

Diverse roles of Synaptotagmin-7 in regulating vesicle fusion

(2020) Vincent Huson et al.   CURRENT OPINION IN NEUROBIOLOGY

Tau is not necessary for amyloid-beta–induced synaptic and memory impairments

(2020) Daniela Puzzo et al.   JOURNAL OF CLINICAL INVESTIGATION

Heart and Brain: Complex Relationships for Left Ventricular Dysfunction

(2020) Gianlorenzo Daniele et al.   Current Cardiology Reports

The Emerging Role of RHOT1/Miro1 in the Pathogenesis of Parkinson's Disease

(2020) Dajana Grossmann et al.   Frontiers in Neurology

Role of defective calcium regulation in cardiorespiratory dysfunction in Huntington’s disease

(2020) Haikel Dridi et al.   JCI Insight

Ryanodine receptor remodeling in cardiomyopathy and muscular dystrophy caused by lamin A/C gene mutation

(2020) Haikel Dridi et al.   HUMAN MOLECULAR GENETICS

diaPASEF: parallel accumulation–serial fragmentation combined with data-independent acquisition

(2020) Florian Meier et al.   NATURE METHODS

Mitochondrial oxidative stress induces leaky ryanodine receptor during mechanical ventilation

(2019) Haikel Dridi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Sympathetic activation in congestive heart failure: an updated overview

(2019) Guido Grassi et al.   HEART FAILURE REVIEWS

TGFβRI antagonist inhibits HIV-1 Nef-induced CC chemokine family ligand 2 (CCL2) in the brain and prevents spatial learning impairment

(2019) Gladys Chompre et al.   Journal of Neuroinflammation

Long-Term Cognitive Decline After Newly Diagnosed Heart Failure

(2018) Christa A. Hammond et al.   Circulation-Heart Failure

Amyloid β production is regulated by β2-adrenergic signaling-mediated post-translational modifications of the ryanodine receptor

(2017) Renaud Bussiere et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inflammation in epileptogenesis after traumatic brain injury

(2017) Kyria M. Webster et al.   Journal of Neuroinflammation

Heart failure: HF-induced diaphragmatic atrophy and weakness

(2017) Karina Huynh   Nature Reviews Cardiology

Association of β-Blockers With Functional Outcomes, Death, and Rehospitalization in Older Nursing Home Residents After Acute Myocardial Infarction

(2017) Michael A. Steinman et al.   JAMA Internal Medicine

Catecholaminergic Neuromodulation Shapes Intrinsic MRI Functional Connectivity in the Human Brain

(2016) Ruud L. van den Brink et al.   JOURNAL OF NEUROSCIENCE

Neurohormonal activation in heart failure with reduced ejection fraction

(2016) Justin Hartupee et al.   Nature Reviews Cardiology

The pre-synaptic vesicle protein synaptotagmin is a novel biomarker for Alzheimer’s disease

(2016) Annika Öhrfelt et al.   Alzheimers Research & Therapy

Calcium release channel RyR2 regulates insulin release and glucose homeostasis

(2015) Gaetano Santulli et al.   JOURNAL OF CLINICAL INVESTIGATION

Excess TGF-β mediates muscle weakness associated with bone metastases in mice

(2015) David L Waning et al.   NATURE MEDICINE

Cortical Membrane Potential Signature of Optimal States for Sensory Signal Detection

(2015) Matthew J. McGinley et al.   NEURON

Mitochondrial calcium overload is a key determinant in heart failure

(2015) Gaetano Santulli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Burden of Comorbidities and Functional and Cognitive Impairments in Elderly Patients at the Initial Diagnosis of Heart Failure and Their Impact on Total Mortality

(2015) Khalil Murad et al.   JACC-Heart Failure

Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging

(2015) Gaetano Santulli et al.   Current Molecular Pharmacology

Cognitive status in patients hospitalized with acute decompensated heart failure

(2014) Seth N. Levin et al.   AMERICAN HEART JOURNAL

The Principle of Membrane Fusion in the Cell (Nobel Lecture)

(2014) James Edward Rothman   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Stimulation of NOX2 in isolated hearts reversibly sensitizes RyR2 channels to activation by cytoplasmic calcium

(2014) Paulina Donoso et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The Global Health and Economic Burden of Hospitalizations for Heart Failure

(2014) Andrew P. Ambrosy et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

SNAP-25 is a promising novel cerebrospinal fluid biomarker for synapse degeneration in Alzheimer’s disease

(2014) Ann Brinkmalm et al.   Molecular Neurodegeneration

Structure of a mammalian ryanodine receptor

(2014) Ran Zalk et al.   NATURE

Pupil Fluctuations Track Fast Switching of Cortical States during Quiet Wakefulness

(2014) Jacob Reimer et al.   NEURON

Inhibition of Transforming Growth Factor-β Attenuates Brain Injury and Neurological Deficits in a Rat Model of Germinal Matrix Hemorrhage

(2014) Anatol Manaenko et al.   STROKE

Propranolol reduces cognitive deficits, amyloid and tau pathology in Alzheimer's transgenic mice

(2013) Marta Dobarro et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Modifications of skeletal muscle ryanodine receptor type 1 and exercise intolerance in heart failure

(2013) Eric Rullman et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Object recognition test in mice

(2013) Marianne Leger et al.   Nature Protocols

Antihypertensive medication use and risk of cognitive impairment: The Honolulu-Asia Aging Study

(2013) R. P. Gelber et al.   NEUROLOGY

Role of Leaky Neuronal Ryanodine Receptors in Stress- Induced Cognitive Dysfunction

(2012) Xiaoping Liu et al.   CELL

Evaluation of Breast Tumor Blood Flow with Dynamic First-Pass 18F-FDG PET/CT: Comparison with Angiogenesis Markers and Prognostic Factors

(2012) A. Cochet et al.   JOURNAL OF NUCLEAR MEDICINE

Orienting and Reorienting: The Locus Coeruleus Mediates Cognition through Arousal

(2012) Susan J. Sara et al.   NEURON

Noradrenergic Neurons of the Locus Coeruleus Are Phase Locked to Cortical Up-Down States during Sleep

(2011) Oxana Eschenko et al.   CEREBRAL CORTEX

Heart failure and cognitive function in the general population: the Hoorn Study

(2011) Katja van den Hurk et al.   EUROPEAN JOURNAL OF HEART FAILURE

Role of chronic ryanodine receptor phosphorylation in heart failure and β-adrenergic receptor blockade in mice

(2010) Jian Shan et al.   JOURNAL OF CLINICAL INVESTIGATION

Phosphorylation of the ryanodine receptor mediates the cardiac fight or flight response in mice

(2010) Jian Shan et al.   JOURNAL OF CLINICAL INVESTIGATION

NADPH Oxidase-Dependent Regulation of T-Type Ca2+ Channels and Ryanodine Receptors Mediate the Augmented Exocytosis of Catecholamines from Intermittent Hypoxia-Treated Neonatal Rat Chromaffin Cells

(2010) D. Souvannakitti et al.   JOURNAL OF NEUROSCIENCE

Role of CaMKII  phosphorylation of the cardiac ryanodine receptor in the force frequency relationship and heart failure

(2010) A. Kushnir et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Elevated Plus Maze for Mice

(2009) Munekazu Komada et al.   Jove-Journal of Visualized Experiments

Factors influencing medication adherence in patients with heart failure

(2008) Jia-Rong Wu et al.   HEART & LUNG

Tumor Blood Flow Measured by PET Dynamic Imaging of First-Pass 18F-FDG Uptake: A Comparison with 15O-Labeled Water-Measured Blood Flow

(2008) N. A. Mullani et al.   JOURNAL OF NUCLEAR MEDICINE