Inosine, an Endogenous Purine Nucleoside, Suppresses Immune Responses and Protects Mice from Experimental Autoimmune Encephalomyelitis: a Role for A2A Adenosine Receptor

Evidence for anxiolytic effects of acute caffeine on anxiety-related behavior in male and female rats tested with and without bright light

(2014) Robert N. Hughes et al.   BEHAVIOURAL BRAIN RESEARCH

Leukocyte infiltration into spinal cord of EAE mice is attenuated by removal of endothelial leptin signaling

(2014) Suidong Ouyang et al.   BRAIN BEHAVIOR AND IMMUNITY

Inosine improves functional recovery after experimental traumatic brain injury

(2014) Shlomit Dachir et al.   BRAIN RESEARCH

Multidisciplinary Management of Multiple Sclerosis Symptoms

(2014) Philippe Gallien et al.   EUROPEAN NEUROLOGY

Rutin, a Flavonoid and Principal Component of Saussurea Involucrata, Attenuates Physical Fatigue in a Forced Swimming Mouse Model

(2014) Kang-Yi Su et al.   International Journal of Medical Sciences

Multiple sclerosis genetics

(2014) Stephen Sawcer et al.   LANCET NEUROLOGY

Adenosine A1 Receptor-Dependent Antinociception Induced by Inosine in Mice: Pharmacological, Genetic and Biochemical Aspects

(2014) Francisney Pinto Nascimento et al.   MOLECULAR NEUROBIOLOGY

Lack of interleukin-17 leads to a modulated micro-environment and amelioration of mechanical hypersensitivity after peripheral nerve injury in mice

(2014) Yuan-Ji Day et al.   PAIN

Oral administration of inosine produces antidepressant-like effects in mice

(2014) Junko Muto et al.   Scientific Reports

Altered cognitive-emotional behavior in early experimental autoimmune encephalitis – Cytokine and hormonal correlates

(2013) Shaona Acharjee et al.   BRAIN BEHAVIOR AND IMMUNITY

Management of cognition and fatigue

(2013) Susan M. Rubin   DM DISEASE-A-MONTH

Multiple sclerosis lymphocytes upregulate A2Aadenosine receptors that are antiinflammatory when stimulated

(2013) Fabrizio Vincenzi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Astrocytes play a key role in EAE pathophysiology by orchestrating in the CNS the inflammatory response of resident and peripheral immune cells and by suppressing remyelination

(2013) Roberta Brambilla et al.   GLIA

Adenosine A2A Receptors in Secondary Progressive Multiple Sclerosis: A [11C]TMSX Brain PET Study

(2013) Eero Rissanen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The role of kinin B1 and B2 receptors in the persistent pain induced by experimental autoimmune encephalomyelitis (EAE) in mice: Evidence for the involvement of astrocytes

(2013) Rafael C. Dutra et al.   NEUROBIOLOGY OF DISEASE

Anxiety state affects information processing speed in patients with multiple sclerosis

(2013) Benedetta Goretti et al.   NEUROLOGICAL SCIENCES

Inosine Enhances Axon Sprouting and Motor Recovery after Spinal Cord Injury

(2013) Daniel Kim et al.   PLoS One

Anti-inflammatory effects of inosine in allergic lung inflammation in mice: evidence for the participation of adenosine A2A and A3 receptors

(2013) Fernanda da Rocha Lapa et al.   Purinergic Signalling

The antidepressant-like effect of inosine in the FST is associated with both adenosine A1 and A2A receptors

(2013) Manuella P. Kaster et al.   Purinergic Signalling

Predictors of long-term outcome in multiple sclerosis patients treated with interferon beta

(2012) Robert A. Bermel et al.   ANNALS OF NEUROLOGY

Multiple sclerosis

(2012) Alyssa Nylander et al.   JOURNAL OF CLINICAL INVESTIGATION

A2A Adenosine Receptor Signaling in Lymphocytes and the Central Nervous System Regulates Inflammation during Experimental Autoimmune Encephalomyelitis

(2012) J. H. Mills et al.   JOURNAL OF IMMUNOLOGY

Pain in experimental autoimmune encephalitis: a comparative study between different mouse models

(2012) Jianning Lu et al.   Journal of Neuroinflammation

Anti-inflammatory effects of purine nucleosides, adenosine and inosine, in a mouse model of pleurisy: evidence for the role of adenosine A2 receptors

(2012) Fernanda da Rocha Lapa et al.   Purinergic Signalling

Inflammation modulates anxiety in an animal model of multiple sclerosis

(2011) Isabella Peruga et al.   BEHAVIOURAL BRAIN RESEARCH

Euphol prevents experimental autoimmune encephalomyelitis in mice: Evidence for the underlying mechanisms

(2011) Rafael Cypriano Dutra et al.   BIOCHEMICAL PHARMACOLOGY

Immunopathogenesis of multiple sclerosis

(2011) Manuel Comabella et al.   CLINICAL IMMUNOLOGY

Cost of multiple sclerosis in the Czech Republic: The COMS study

(2011) J Blahova Dusankova et al.   Multiple Sclerosis Journal

The Role of Kinin Receptors in Preventing Neuroinflammation and Its Clinical Severity during Experimental Autoimmune Encephalomyelitis in Mice

(2011) Rafael C. Dutra et al.   PLoS One

Interleukin-17 Contributes to Neuroinflammation and Neuropathic Pain Following Peripheral Nerve Injury in Mice

(2010) Cristina Fabiola Kim et al.   JOURNAL OF PAIN

Inosine Reduces Pain-Related Behavior in Mice: Involvement of Adenosine A1 and A2A Receptor Subtypes and Protein Kinase C Pathways

(2010) F. P. Nascimento et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Vitamin D and multiple sclerosis

(2010) Alberto Ascherio et al.   LANCET NEUROLOGY

Central pain in multiple sclerosis - Sensory abnormalities

(2009) A. Österberg et al.   EUROPEAN JOURNAL OF PAIN

The Treatment of Multiple Sclerosis with Inosine

(2009) Clyde E. Markowitz et al.   JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE

Inhibition of ERK MAPK Suppresses IL-23- and IL-1-Driven IL-17 Production and Attenuates Autoimmune Disease

(2009) C. F. Brereton et al.   JOURNAL OF IMMUNOLOGY

Inosine Alters Gene Expression and Axonal Projections in Neurons Contralateral to a Cortical Infarct and Improves Skilled Use of the Impaired Limb

(2009) L. Zai et al.   JOURNAL OF NEUROSCIENCE

The Causal Cascade to Multiple Sclerosis: A Model for MS Pathogenesis

(2009) Douglas S. Goodin   PLoS One

T helper cell type 1 (Th1), Th2 and Th17 responses to myelin basic protein and disease activity in multiple sclerosis

(2008) Chris J. Hedegaard et al.   IMMUNOLOGY

The Th17–ELR+CXC chemokine pathway is essential for the development of central nervous system autoimmune disease

(2008) Thaddeus Carlson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Multiple sclerosis

(2008) Alastair Compston et al.   LANCET

p42/44 MAPK is an essential effector for purine nucleoside-mediated neuroprotection of hypoxic PC12 cells and primary cerebellar granule neurons

(2008) Bettina Tomaselli et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Switching first-line disease-modifying therapy after failure: impact on the course of relapsing–remitting multiple sclerosis

(2008) A Gajofatto et al.   Multiple Sclerosis Journal

Differential regulation of central nervous system autoimmunity by TH1 and TH17 cells

(2008) Ingunn M Stromnes et al.   NATURE MEDICINE

Interleukin-17 Production in Central Nervous System-Infiltrating T Cells and Glial Cells Is Associated with Active Disease in Multiple Sclerosis

(2007) John S. Tzartos et al.   AMERICAN JOURNAL OF PATHOLOGY

Glucocorticoids regulate innate immunity in a model of multiple sclerosis: reciprocal interactions between the A1 adenosine receptor and β-arrestin-1 in monocytoid cells

(2007) Shigeki Tsutsui et al.   FASEB JOURNAL

Pain associated with multiple sclerosis: Systematic review and proposed classification

(2007) Alec B. O’Connor et al.   PAIN