CD8+ T cells pump the brakes on Alzheimer’s disease

Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy

(2023) Xiaoying Chen et al.   NATURE

CXCR6 orchestrates brain CD8+ T cell residency and limits mouse Alzheimer’s disease pathology

(2023) Wei Su et al.   NATURE IMMUNOLOGY

The role of antiviral CD8+ T cells in cognitive impairment

(2022) Katie L. Reagin et al.   CURRENT OPINION IN NEUROBIOLOGY

Transcriptomic Profiling Identifies CD8+T Cells in the Brain of Aged and Alzheimer’s Disease Transgenic Mice as Tissue-Resident Memory T Cells

(2022) Barbara Altendorfer et al.   JOURNAL OF IMMUNOLOGY

Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer’s disease

(2020) David Gate et al.   NATURE

CD8+ T-cells infiltrate Alzheimer’s disease brains and regulate neuronal- and synapse-related gene expression in APP-PS1 transgenic mice

(2020) M.S. Unger et al.   BRAIN BEHAVIOR AND IMMUNITY

PD-1/PD-L1 checkpoint blockade harnesses monocyte-derived macrophages to combat cognitive impairment in a tauopathy mouse model

(2019) Neta Rosenzweig et al.   Nature Communications

Disease-Associated Microglia: A Universal Immune Sensor of Neurodegeneration

(2018) Aleksandra Deczkowska et al.   CELL

PD-1 immune checkpoint blockade reduces pathology and improves memory in mouse models of Alzheimer's disease

(2016) Kuti Baruch et al.   NATURE MEDICINE

Tissue-Resident Memory T Cells

(2014) Jason M. Schenkel et al.   IMMUNITY