Systemic Central Nervous System (CNS)-targeted Delivery of Neuropeptide Y (NPY) Reduces Neurodegeneration and Increases Neural Precursor Cell Proliferation in a Mouse Model of Alzheimer Disease

A brain-targeted, modified neurosin (kallikrein-6) reduces α-synuclein accumulation in a mouse model of multiple system atrophy

(2015) Brian Spencer et al.   Molecular Neurodegeneration

Circadian clock disruption in neurodegenerative diseases: cause and effect?

(2015) Erik S. Musiek   Frontiers in Pharmacology

The effect of neuropeptide Y on cell survival and neurotrophin expression in in-vitro models of Alzheimer’s disease

(2014) Francesco Angelucci et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

A Neuroprotective Brain-penetrating Endopeptidase Fusion Protein Ameliorates Alzheimer Disease Pathology and Restores Neurogenesis

(2014) Brian Spencer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ESCRT-mediated Uptake and Degradation of Brain-targeted α-synuclein Single Chain Antibody Attenuates Neuronal Degeneration In Vivo

(2014) Brian Spencer et al.   MOLECULAR THERAPY

The Neurogenic Effects of Exogenous Neuropeptide Y: Early Molecular Events and Long-Lasting Effects in the Hippocampus of Trimethyltin-Treated Rats

(2014) Valentina Corvino et al.   PLoS One

Immunotherapy for Alzheimer’s disease: past, present and future

(2014) Brian Spencer et al.   Frontiers in Aging Neuroscience

Neurotoxicity of Amyloid  -Protein: Synaptic and Network Dysfunction

(2013) L. Mucke et al.   Cold Spring Harbor Perspectives in Medicine

Neuropeptide Y Protects Rat Cortical Neurons against β-Amyloid Toxicity and Re-establishes Synthesis and Release of Nerve Growth Factor

(2012) Nicoletta Croce et al.   ACS Chemical Neuroscience

Protective role of neuropeptide Y Y2receptors in cell death and microglial response following methamphetamine injury

(2012) Joana Gonçalves et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Neuropeptide Y and its role in CNS disease and repair

(2012) M. Decressac et al.   EXPERIMENTAL NEUROLOGY

Methamphetamine-induced changes in the mice hippocampal neuropeptide Y system: implications for memory impairment

(2012) Joana Gonçalves et al.   JOURNAL OF NEUROCHEMISTRY

Neuropeptide Alterations in the Infundibular Nucleus of Huntington's Disease Patients

(2012) D. J. van Wamelen et al.   JOURNAL OF NEUROENDOCRINOLOGY

Antibody-Aided Clearance of Extracellular  -Synuclein Prevents Cell-to-Cell Aggregate Transmission

(2012) E.-J. Bae et al.   JOURNAL OF NEUROSCIENCE

Lentivirus Mediated Delivery of Neurosin Promotes Clearance of Wild-type α-Synuclein and Reduces the Pathology in an α-Synuclein Model of LBD

(2012) Brian Spencer et al.   MOLECULAR THERAPY

Neuropeptide Y promotes neurogenesis and protection against methamphetamine-induced toxicity in mouse dentate gyrus-derived neurosphere cultures

(2012) Sofia Baptista et al.   NEUROPHARMACOLOGY

Thy1-hAPPLond/Swe+mouse model of Alzheimer's disease displays broad behavioral deficits in sensorimotor, cognitive and social function

(2012) Mehrdad Faizi et al.   Brain and Behavior

Neuroprotective Effect of Neuropeptide Y against Beta-Amyloid 25–35 Toxicity in SH-SY5Y Neuroblastoma Cells Is Associated with Increased Neurotrophin Production

(2011) Nicoletta Croce et al.   Neurodegenerative Diseases

Altered expression of neuropeptides in the primary somatosensory cortex of the Down syndrome model Ts65Dn

(2011) Samuel Hernández et al.   NEUROPEPTIDES

Peripheral Delivery of a CNS Targeted, Metalo-Protease Reduces Aβ Toxicity in a Mouse Model of Alzheimer's Disease

(2011) Brian Spencer et al.   PLoS One

Progressive accumulation of amyloid-β oligomers in Alzheimer’s disease and in amyloid precursor protein transgenic mice is accompanied by selective alterations in synaptic scaffold proteins

(2010) Emiley Pham et al.   FEBS Journal

Neuropeptide Y Modulation of Interleukin-1β (IL-1β)-induced Nitric Oxide Production in Microglia

(2010) Raquel Ferreira et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NPY promotes chemokinesis and neurogenesis in the rat subventricular zone

(2010) Nathalie Thiriet et al.   JOURNAL OF NEUROCHEMISTRY

Neurodegeneration in a Transgenic Mouse Model of Multiple System Atrophy Is Associated with Altered Expression of Oligodendroglial-Derived Neurotrophic Factors

(2010) K. Ubhi et al.   JOURNAL OF NEUROSCIENCE

Increased BMP6 Levels in the Brains of Alzheimer's Disease Patients and APP Transgenic Mice Are Accompanied by Impaired Neurogenesis

(2010) L. Crews et al.   JOURNAL OF NEUROSCIENCE

Transsynaptic Progression of Amyloid-β-Induced Neuronal Dysfunction within the Entorhinal-Hippocampal Network

(2010) Julie A. Harris et al.   NEURON

Selective Molecular Alterations in the Autophagy Pathway in Patients with Lewy Body Disease and in Models of α-Synucleinopathy

(2010) Leslie Crews et al.   PLoS One

Amyloid beta-derived neuroplasticity in bone marrow-derived mesenchymal stem cells is mediated by NPY and 5-HT2B receptorsviaERK1/2 signalling pathways

(2009) H. K. Jin et al.   CELL PROLIFERATION

Neuropeptide Y Fragments Derived from Neprilysin Processing Are Neuroprotective in a Transgenic Model of Alzheimer's Disease

(2009) J. B. Rose et al.   JOURNAL OF NEUROSCIENCE

Beclin 1 Gene Transfer Activates Autophagy and Ameliorates the Neurodegenerative Pathology in  -Synuclein Models of Parkinson's and Lewy Body Diseases

(2009) B. Spencer et al.   JOURNAL OF NEUROSCIENCE

Transthyretin protects Alzheimer's mice from the behavioral and biochemical effects of A  toxicity

(2008) J. N. Buxbaum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuropeptide Y Promotes Neurogenesis in Murine Subventricular Zone

(2008) Fabienne Agasse et al.   STEM CELLS

Mutant α-synuclein exacerbates age-related decrease of neurogenesis

(2007) Beate Winner et al.   NEUROBIOLOGY OF AGING