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Title
Microtubule Destabilization Paves the Way to Parkinson’s Disease
Authors
Keywords
Microtubule, Neuron health, Neurodegeneration, Parkinson’s disease, Tubulin-targeted therapy
Journal
MOLECULAR NEUROBIOLOGY
Volume 54, Issue 9, Pages 6762-6774
Publisher
Springer Nature
Online
2016-10-18
DOI
10.1007/s12035-016-0188-5
References
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Note: Only part of the references are listed.- Novel Tubulin and Tau Neuroprotective Fragments Sharing Structural Similarities with the Drug Candidate NAP (Davuentide)
- (2018) Illana Gozes et al. JOURNAL OF ALZHEIMERS DISEASE
- Lewy Bodies and the Mechanisms of Neuronal Cell Death in Parkinson's Disease and Dementia with Lewy Bodies
- (2016) John H. T. Power et al. BRAIN PATHOLOGY
- Structure and Dynamics of Single-isoform Recombinant Neuronal Human Tubulin
- (2016) Annapurna Vemu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Promotion of Functional Nerve Regeneration by Inhibition of Microtubule Detyrosination
- (2016) P. Gobrecht et al. JOURNAL OF NEUROSCIENCE
- Dendrites In Vitro and In Vivo Contain Microtubules of Opposite Polarity and Axon Formation Correlates with Uniform Plus-End-Out Microtubule Orientation
- (2016) K. W. Yau et al. JOURNAL OF NEUROSCIENCE
- α-Synuclein is a Novel Microtubule Dynamase
- (2016) Daniele Cartelli et al. Scientific Reports
- Linking microtubules to Parkinson's disease: the case of parkin
- (2015) Graziella Cappelletti et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Closing the tau loop: the missing tau mutation
- (2015) Allan McCarthy et al. BRAIN
- Coordinating Neuronal Actin–Microtubule Dynamics
- (2015) Charlotte H. Coles et al. CURRENT BIOLOGY
- Tubulin-tyrosine Ligase (TTL)-mediated Increase in Tyrosinated α-Tubulin in Injured Axons Is Required for Retrograde Injury Signaling and Axon Regeneration
- (2015) Wenjun Song et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Microtubules self-repair in response to mechanical stress
- (2015) Laura Schaedel et al. NATURE MATERIALS
- Pathogenesis of Parkinson disease—the gut–brain axis and environmental factors
- (2015) Lisa Klingelhoefer et al. Nature Reviews Neurology
- Building the Neuronal Microtubule Cytoskeleton
- (2015) Lukas C. Kapitein et al. NEURON
- Systemic administration of epothilone B promotes axon regeneration after spinal cord injury
- (2015) J. Ruschel et al. SCIENCE
- Impaired intracellular trafficking defines early Parkinson's disease
- (2015) Benjamin H.M. Hunn et al. TRENDS IN NEUROSCIENCES
- Potential application of lithium in Parkinson's and other neurodegenerative diseases
- (2015) Carol A. Lazzara et al. Frontiers in Neuroscience
- Neurite Aggregation and Calcium Dysfunction in iPSC-Derived Sensory Neurons with Parkinson’s Disease-Related LRRK2 G2019S Mutation
- (2015) Andrew J. Schwab et al. Stem Cell Reports
- Molecular Basis for Age-Dependent Microtubule Acetylation by Tubulin Acetyltransferase
- (2014) Agnieszka Szyk et al. CELL
- Decreased SIRT2 activity leads to altered microtubule dynamics in oxidatively-stressed neuronal cells: Implications for Parkinson's disease
- (2014) Vivek P. Patel et al. EXPERIMENTAL NEUROLOGY
- The tubulin code: Molecular components, readout mechanisms, and functions
- (2014) Carsten Janke JOURNAL OF CELL BIOLOGY
- Effect of taxoid and nontaxoid site microtubule-stabilizing agents on axonal transport of mitochondria in untransfected and ECFP-htau40-transfected rat cortical neurons in culture
- (2014) Viswanath Das et al. JOURNAL OF NEUROSCIENCE RESEARCH
- The elongation of primary cilia via the acetylation of α-tubulin by the treatment with lithium chloride in human fibroblast KD cells
- (2014) Takashi Nakakura et al. Medical Molecular Morphology
- Regulation of microtubule motors by tubulin isotypes and post-translational modifications
- (2014) Minhajuddin Sirajuddin et al. NATURE CELL BIOLOGY
- Exome-wide Rare Variant Analysis Identifies TUBA4A Mutations Associated with Familial ALS
- (2014) Bradley N. Smith et al. NEURON
- Parkin Mutations Reduce the Complexity of Neuronal Processes in iPSC-Derived Human Neurons
- (2014) Yong Ren et al. STEM CELLS
- Lost after translation: missorting of Tau protein and consequences for Alzheimer disease
- (2014) Hans Zempel et al. TRENDS IN NEUROSCIENCES
- An assay to image neuronal microtubule dynamics in mice
- (2014) Tatjana Kleele et al. Nature Communications
- Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations
- (2014) Vinay K. Godena et al. Nature Communications
- The rescue of microtubule-dependent traffic recovers mitochondrial function in Parkinson's disease
- (2013) A.R. Esteves et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Microtubule dynamic instability: A new model with coupled GTP hydrolysis and multistep catastrophe
- (2013) Hugo Bowne-Anderson et al. BIOESSAYS
- Beyond taxol: microtubule-based treatment of disease and injury of the nervous system
- (2013) Peter W. Baas et al. BRAIN
- Evolving Tip Structures Can Explain Age-Dependent Microtubule Catastrophe
- (2013) Courtney E. Coombes et al. CURRENT BIOLOGY
- β-Tubulin mutations that cause severe neuropathies disrupt axonal transport
- (2013) Shinsuke Niwa et al. EMBO JOURNAL
- A Direct Interaction between Leucine-rich Repeat Kinase 2 and Specific β-Tubulin Isoforms Regulates Tubulin Acetylation
- (2013) Bernard M. H. Law et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- α-Synuclein Oligomers Impair Neuronal Microtubule-Kinesin Interplay
- (2013) Iryna Prots et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Structural basis of tubulin tyrosination by tubulin tyrosine ligase
- (2013) Andrea E. Prota et al. JOURNAL OF CELL BIOLOGY
- HDAC6 as a target for neurodegenerative diseases: what makes it different from the other HDACs?
- (2013) Claudia Simões-Pires et al. Molecular Neurodegeneration
- Axonal transport deficits and neurodegenerative diseases
- (2013) Stéphanie Millecamps et al. NATURE REVIEWS NEUROSCIENCE
- The energy cost of action potential propagation in dopamine neurons: clues to susceptibility in Parkinson's disease
- (2013) Eleftheria K. Pissadaki et al. Frontiers in Computational Neuroscience
- Microtubule Alterations Occur Early in Experimental Parkinsonism and The Microtubule Stabilizer Epothilone D Is Neuroprotective
- (2013) Daniele Cartelli et al. Scientific Reports
- Alterations in axonal transport motor proteins in sporadic and experimental Parkinson’s disease
- (2012) Yaping Chu et al. BRAIN
- Tubulins as Therapeutic Targets in Cancer: from Bench to Bedside
- (2012) Christos D. Katsetos et al. CURRENT PHARMACEUTICAL DESIGN
- Microtubule-severing enzymes at the cutting edge
- (2012) D. J. Sharp et al. JOURNAL OF CELL SCIENCE
- The Microtubule-Stabilizing Agent, Epothilone D, Reduces Axonal Dysfunction, Neurotoxicity, Cognitive Deficits, and Alzheimer-Like Pathology in an Interventional Study with Aged Tau Transgenic Mice
- (2012) B. Zhang et al. JOURNAL OF NEUROSCIENCE
- DJ-1 deficiency perturbs microtubule dynamics and impairs striatal neurite outgrowth
- (2012) Chengyu Sheng et al. NEUROBIOLOGY OF AGING
- Microtubule Destabilization Is Shared by Genetic and Idiopathic Parkinson’s Disease Patient Fibroblasts
- (2012) Daniele Cartelli et al. PLoS One
- Depolymerizing Kinesins Kip3 and MCAK Shape Cellular Microtubule Architecture by Differential Control of Catastrophe
- (2011) Melissa K. Gardner et al. CELL
- PINK1 and Parkin Target Miro for Phosphorylation and Degradation to Arrest Mitochondrial Motility
- (2011) Xinnan Wang et al. CELL
- Phenotypic spectrum of the tubulin-related disorders and functional implications of disease-causing mutations
- (2011) Max A Tischfield et al. CURRENT OPINION IN GENETICS & DEVELOPMENT
- The Parkinsonian Mimetic, MPP+, Specifically Impairs Mitochondrial Transport in Dopamine Axons
- (2011) J. S. Kim-Han et al. JOURNAL OF NEUROSCIENCE
- Microtubule Stabilization Reduces Scarring and Causes Axon Regeneration After Spinal Cord Injury
- (2011) F. Hellal et al. SCIENCE
- Free Tubulin Modulates Mitochondrial Membrane Potential in Cancer Cells
- (2010) E. N. Maldonado et al. CANCER RESEARCH
- A Family of Protein-Deglutamylating Enzymes Associated with Neurodegeneration
- (2010) Krzysztof Rogowski et al. CELL
- Mixed Microtubules Steer Dynein-Driven Cargo Transport into Dendrites
- (2010) Lukas C. Kapitein et al. CURRENT BIOLOGY
- Microtubule dysfunction precedes transport impairment and mitochondria damage in MPP+-induced neurodegeneration
- (2010) Daniele Cartelli et al. JOURNAL OF NEUROCHEMISTRY
- Epothilone D Improves Microtubule Density, Axonal Integrity, and Cognition in a Transgenic Mouse Model of Tauopathy
- (2010) K. R. Brunden et al. JOURNAL OF NEUROSCIENCE
- A pilot trial of the microtubule-interacting peptide (NAP) in mice overexpressing alpha-synuclein shows improvement in motor function and reduction of alpha-synuclein inclusions
- (2010) Sheila M. Fleming et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- MEC-17 is an α-tubulin acetyltransferase
- (2010) Jyothi S. Akella et al. NATURE
- Missing pieces in the Parkinson's disease puzzle
- (2010) Jose A Obeso et al. NATURE MEDICINE
- Microtubule depolymerization potentiates alpha-synuclein oligomerization
- (2010) A. Raquel Esteves Frontiers in Aging Neuroscience
- Microtubule Depolymerization Suppresses α-Synuclein Accumulation in a Mouse Model of Multiple System Atrophy
- (2009) Kimiko Nakayama et al. AMERICAN JOURNAL OF PATHOLOGY
- Motor-dependent microtubule disassembly driven by tubulin tyrosination
- (2009) Leticia Peris et al. JOURNAL OF CELL BIOLOGY
- Leucine-rich repeat kinase 2 phosphorylates brain tubulin-beta isoforms and modulates microtubule stability - a point of convergence in Parkinsonian neurodegeneration?
- (2009) Frank Gillardon JOURNAL OF NEUROCHEMISTRY
- Dynamic Changes in Presynaptic and Axonal Transport Proteins Combined with Striatal Neuroinflammation Precede Dopaminergic Neuronal Loss in a Rat Model of AAV -Synucleinopathy
- (2009) C. Y. Chung et al. JOURNAL OF NEUROSCIENCE
- Molecular interaction of α-synuclein with tubulin influences on the polymerization of microtubule in vitro and structure of microtubule in cells
- (2009) R. M. Zhou et al. MOLECULAR BIOLOGY REPORTS
- In silico design of tubulin-targeted antimitotic peptides
- (2009) Stefano Pieraccini et al. Nature Chemistry
- Tubulin Tyrosination Is Required for the Proper Organization and Pathfinding of the Growth Cone
- (2009) Séverine Marcos et al. PLoS One
- Parkin Protects Dopaminergic Neurons against Microtubule-depolymerizing Toxins by Attenuating Microtubule-associated Protein Kinase Activation
- (2008) Yong Ren et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Differential trafficking of Kif5c on tyrosinated and detyrosinated microtubules in live cells
- (2008) S. Dunn et al. JOURNAL OF CELL SCIENCE
- Intrastriatal injection of colchicine induces striatonigral degeneration in mice
- (2008) Yajie Liang et al. JOURNAL OF NEUROCHEMISTRY
- Tubulin binding blocks mitochondrial voltage-dependent anion channel and regulates respiration
- (2008) T. K. Rostovtseva et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mitochondrial complex I inhibition is not required for dopaminergic neuron death induced by rotenone, MPP+, or paraquat
- (2008) W.-S. Choi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Polarized microtubule arrays in apical dendrites and axons
- (2008) A. C. Kwan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Tau-Induced Traffic Jams Reflect Organelles Accumulation at Points of Microtubule Polar Mismatching
- (2008) Or A. Shemesh et al. TRAFFIC
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