Heteroreceptor Complexes Formed by Dopamine D1, Histamine H3, and N-Methyl-D-Aspartate Glutamate Receptors as Targets to Prevent Neuronal Death in Alzheimer’s Disease

Quaternary structure of a G-protein-coupled receptor heterotetramer in complex with Gi and Gs

(2016) Gemma Navarro et al.   BMC BIOLOGY

Presynaptic P2X1-3 and α3-containing nicotinic receptors assemble into functionally interacting ion channels in the rat hippocampus

(2016) Ricardo J. Rodrigues et al.   NEUROPHARMACOLOGY

Basic Pharmacological and Structural Evidence for Class A G-Protein-Coupled Receptor Heteromerization

(2016) Rafael Franco et al.   Frontiers in Pharmacology

A Randomized, Double-Blind, Placebo-Controlled, 16-Week Study of the H3 Receptor Antagonist, GSK239512 as a Monotherapy in Subjects with Mild-to-Moderate Alzheimer’s Disease

(2014) Richard Grove et al.   Current Alzheimer Research

Targeting the NMDA receptor subunit NR2B for treating or preventing age-related memory decline

(2014) Deheng Wang et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Cocaine Disrupts Histamine H3 Receptor Modulation of Dopamine D1 Receptor Signaling:  1-D1-H3 Receptor Complexes as Key Targets for Reducing Cocaine's Effects

(2014) E. Moreno et al.   JOURNAL OF NEUROSCIENCE

Dopaminergic neurons promote hippocampal reactivation and spatial memory persistence

(2014) Colin G McNamara et al.   NATURE NEUROSCIENCE

Memantine in Patients with Moderate to Severe Alzheimer's Disease: Meta-Analyses Using Realistic Definitions of Response

(2013) David Wilkinson et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Cytosolic Sulfotransferase 1A3 Is Induced by Dopamine and Protects Neuronal Cells from Dopamine Toxicity

(2013) Neelima P. Sidharthan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cocaine Inhibits Dopamine D2 Receptor Signaling via Sigma-1-D2 Receptor Heteromers

(2013) Gemma Navarro et al.   PLoS One

Interactions between NMDA and dopamine receptors: A potential therapeutic target

(2012) Min Wang et al.   BRAIN RESEARCH

D1 Receptor Modulation of Action Potential Firing in a Subpopulation of Layer 5 Pyramidal Neurons in the Prefrontal Cortex

(2012) H. J. Seong et al.   JOURNAL OF NEUROSCIENCE

Dopamine-Galanin Receptor Heteromers Modulate Cholinergic Neurotransmission in the Rat Ventral Hippocampus

(2011) E. Moreno et al.   JOURNAL OF NEUROSCIENCE

The role of G protein-coupled receptors in the pathology of Alzheimer's disease

(2011) Amantha Thathiah et al.   NATURE REVIEWS NEUROSCIENCE

Selective Susceptibility of Human Dopaminergic Neural Stem Cells to Dopamine-Induced Apoptosis

(2011) Sung-Man Jeon et al.   Experimental Neurobiology

Therapeutic potential of histamine H3 receptor antagonists in dementias

(2010) P.L. Chazot   DRUG NEWS & PERSPECTIVES

Dopamine D1-histamine H3Receptor Heteromers Provide a Selective Link to MAPK Signaling in GABAergic Neurons of the Direct Striatal Pathway

(2010) Estefanía Moreno et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of D1/D5 Dopamine Receptors Protects Neurons from Synapse Dysfunction Induced by Amyloid-β Oligomers

(2010) Sofia Jürgensen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interactions between Intracellular Domains as Key Determinants of the Quaternary Structure and Function of Receptor Heteromers

(2010) Gemma Navarro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of Histamine H3 Antagonists for the Treatment of Cognitive Disorders and Alzheimer's Disease

(2010) J. D. Brioni et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

In-vivo histamine H3 receptor antagonism activates cellular signaling suggestive of symptomatic and disease modifying efficacy in Alzheimer’s disease

(2010) R. Scott Bitner et al.   NEUROPHARMACOLOGY

Direct involvement of  -1 receptors in the dopamine D1 receptor-mediated effects of cocaine

(2010) G. Navarro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of histamine H3 receptors in Alzheimer's Disease brain and amyloid over-expressing TASTPM mice

(2009) AD Medhurst et al.   BRITISH JOURNAL OF PHARMACOLOGY

Marked changes in signal transduction upon heteromerization of dopamine D1 and histamine H3 receptors

(2009) Carla Ferrada et al.   BRITISH JOURNAL OF PHARMACOLOGY

Detection of Heteromers Formed by Cannabinoid CB1, Dopamine D2, and Adenosine A2AG-Protein-Coupled Receptors by Combining Bimolecular Fluorescence Complementation and Bioluminescence Energy Transfer

(2008) Gemma Navarro et al.   TheScientificWorldJOURNAL