Anesthetic Isoflurane Induces DNA Damage Through Oxidative Stress and p53 Pathway

Exposure to volatile anaesthetics is not followed by a massive induction of single-strand DNA breaks in operation theatre personnel

(2015) Krzysztof Szyfter et al.   JOURNAL OF APPLIED GENETICS

Anesthetic Ketamine-Induced DNA Damage in Different Cell Types In Vivo

(2015) Daniela Dimer Leffa et al.   MOLECULAR NEUROBIOLOGY

DNA damage in neurodegenerative diseases

(2015) Fabio Coppedè et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

γH2AX Assay as DNA Damage Biomarker for Human Population Studies: Defining Experimental Conditions

(2015) María Sánchez-Flores et al.   TOXICOLOGICAL SCIENCES

AKT mediates actinomycin D-induced p53 expression

(2015) Chih-Shou Chen et al.   Oncotarget

The Oxygen-Rich Postnatal Environment Induces Cardiomyocyte Cell-Cycle Arrest through DNA Damage Response

(2014) Bao N. Puente et al.   CELL

Vitamin C Attenuates Isoflurane-Induced Caspase-3 Activation and Cognitive Impairment

(2014) Baiqi Cheng et al.   MOLECULAR NEUROBIOLOGY

Chronic treatment with anesthetic propofol attenuates β-amyloid protein levels in brain tissues of aged mice

(2014) Yiying Zhang et al.   Translational Neurodegeneration

ROS inhibitorN-acetyl-L-cysteine antagonizes the activity of proteasome inhibitors

(2013) Marianna Halasi et al.   BIOCHEMICAL JOURNAL

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

γH2AX as a marker of DNA double strand breaks and genomic instability in human population studies

(2013) Vanessa Valdiglesias et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Anesthetics isoflurane and desflurane differently affect mitochondrial function, learning, and memory

(2012) Yiying Zhang et al.   ANNALS OF NEUROLOGY

The p53 inhibitor, pifithrin-α, suppresses self-renewal of embryonic stem cells

(2012) Essam Mohamed Abdelalim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Isoflurane induces cognitive deficits in the Morris water maze task in rats

(2012) Jennifer K. Callaway et al.   EUROPEAN JOURNAL OF ANAESTHESIOLOGY

Axis of ageing: telomeres, p53 and mitochondria

(2012) Ergün Sahin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

DNA damage checkpoints in stem cells, ageing and cancer

(2012) Tobias Sperka et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Endonuclease VIII-like 1 (NEIL1) promotes short-term spatial memory retention and protects from ischemic stroke-induced brain dysfunction and death in mice

(2012) C. Canugovi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

γH2AX as a novel endpoint to detect DNA damage: Applications for the assessment of the in vitro genotoxicity of cigarette smoke

(2012) Carolina Garcia-Canton et al.   TOXICOLOGY IN VITRO

Lidocaine attenuates cognitive impairment after isoflurane anesthesia in old rats

(2011) Daowei Lin et al.   BEHAVIOURAL BRAIN RESEARCH

The in vivo genotoxicity of cisplatin, isoflurane and halothane evaluated by alkaline comet assay in Swiss albino mice

(2011) Gordana Brozovic et al.   JOURNAL OF APPLIED GENETICS

Phosphorylation of Histone H2A.X as an Early Marker of Neuronal Endangerment following Seizures in the Adult Rat Brain

(2011) S. L. Crowe et al.   JOURNAL OF NEUROSCIENCE

Prolonged mitotic arrest triggers partial activation of apoptosis, resulting in DNA damage and p53 induction

(2011) James D. Orth et al.   MOLECULAR BIOLOGY OF THE CELL

Isoflurane induces hippocampal cell injury and cognitive impairments in adult rats

(2011) Daowei Lin et al.   NEUROPHARMACOLOGY

Accumulation of DNA Damage in Hematopoietic Stem and Progenitor Cells during Human Aging

(2011) Claudia E. Rübe et al.   PLoS One

Cell cycle restriction by histone H2AX limits proliferation of adult neural stem cells

(2011) R. N. Fernando et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lower Isoflurane Concentration Affects Spatial Learning and Neurodegeneration in Adult Mice Compared with Higher Concentrations

(2010) Ana M. Valentim et al.   ANESTHESIOLOGY

Short-term Memory Impairment after Isoflurane in Mice Is Prevented by the α5 γ-Aminobutyric Acid Type A Receptor Inverse Agonist L-655,708

(2010) Bechara J. Saab et al.   ANESTHESIOLOGY

Histone XH2AX Is Required forXenopusAnterior Neural Development

(2010) Sung-Young Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ATM Activation by Oxidative Stress

(2010) Z. Guo et al.   SCIENCE

A Presenilin-1 Mutation Renders Neurons Vulnerable to Isoflurane Toxicity

(2009) Ge Liang et al.   ANESTHESIA AND ANALGESIA

The Mitochondrial Pathway of Anesthetic Isoflurane-induced Apoptosis

(2009) Yiying Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cytoplasmic functions of the tumour suppressor p53

(2009) Douglas R. Green et al.   NATURE

A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity

(2009) Rosa M. Marión et al.   NATURE

DNA repair deficiency and neurological disease

(2009) Peter J. McKinnon   NATURE REVIEWS NEUROSCIENCE

DNA Damage, Aging, and Cancer

(2009) Jan H.J. Hoeijmakers   NEW ENGLAND JOURNAL OF MEDICINE

The common inhalation anesthetic isoflurane induces caspase activation and increases amyloid β-protein level in vivo

(2008) Zhongcong Xie et al.   ANNALS OF NEUROLOGY

DNA-damage repair; the good, the bad, and the ugly

(2008) Razqallah Hakem   EMBO JOURNAL

Nucleic acid oxidation in Alzheimer disease

(2008) Paula I. Moreira et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Inhalation Anesthetic Desflurane Induces Caspase Activation and Increases Amyloid β-Protein Levels under Hypoxic Conditions

(2008) Bin Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An estimation of the global volume of surgery: a modelling strategy based on available data

(2008) Thomas G Weiser et al.   LANCET

Homeostatic functions of the p53 tumor suppressor: Regulation of energy metabolism and antioxidant defense

(2008) Ivan A. Olovnikov et al.   SEMINARS IN CANCER BIOLOGY

Brain and behavior changes in 12-month-old Tg2576 and nontransgenic mice exposed to anesthetics

(2007) Shannon L. Bianchi et al.   NEUROBIOLOGY OF AGING