Sulfoquinovosyl acylpropanediol (SQAP): Inhibition of poly(ADP-ribose) metabolism and enhanced cytotoxicity in homologous recombination repair-deficient Chinese hamster-derived cells

Inhibitors of PARP: Number crunching and structure gazing

(2022) Johannes Rudolph et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for allosteric PARP-1 retention on DNA breaks

(2020) Levani Zandarashvili et al.   SCIENCE

Poly(ADP-Ribose) Glycohydrolase (PARG) vs. Poly(ADP-Ribose) Polymerase (PARP) – Function in Genome Maintenance and Relevance of Inhibitors for Anti-cancer Therapy

(2020) Daniel Harrision et al.   Frontiers in Molecular Biosciences

Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death

(2019) Jerry H. Houl et al.   Nature Communications

Distribution and metabolism of 14C-sulfoquinovosylacylpropanediol (14C-SQAP) after a single intravenous administration in tumor-bearing mice

(2018) Tatsushi Ruike et al.   XENOBIOTICA

A Multimodal Molecular Imaging Study Evaluates Pharmacological Alteration of the Tumor Microenvironment to Improve Radiation Response

(2018) Yoichi Takakusagi et al.   CANCER RESEARCH

Hypersensitivity of BRCA2 deficient cells to rosemary extract explained by weak PARP inhibitory activity

(2017) Cathy Su et al.   Scientific Reports

Use and Abuse of the DPPH• Radical

(2015) Mario C. Foti   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Small PARP inhibitor PJ-34 induces cell cycle arrest and apoptosis of adult T-cell leukemia cells

(2015) Xue Tao Bai et al.   Journal of Hematology & Oncology

Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair

(2015) Raphael Ceccaldi et al.   NATURE

Tumor suppressive effect of PARP1 and FOXO3A in gastric cancers and its clinical implications

(2015) See-Hyoung Park et al.   Oncotarget

Novel anticancer agent, SQAP, binds to focal adhesion kinase and modulates its activity

(2015) Jesus Izaguirre-Carbonell et al.   Scientific Reports

Inhibition of hypoxia-inducible factor via upregulation of von Hippel-Lindau protein induces “angiogenic switch off” in a hepatoma mouse model

(2015) Hideki Iwamoto et al.   Molecular Therapy-Oncolytics

SQAGs: A stepping stone in the biotic world

(2013) Nasrin Shaikh et al.   COMPTES RENDUS CHIMIE

Natural and glucosyl flavonoids inhibit poly(ADP-ribose) polymerase activity and induce synthetic lethality in BRCA mutant cells

(2013) JUNKO MAEDA et al.   ONCOLOGY REPORTS

Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors

(2012) J. Murai et al.   CANCER RESEARCH

Inhibition of poly(ADP-ribose) glycohydrolase (PARG) specifically kills BRCA2-deficient tumor cells

(2012) Catherine Fathers et al.   CELL CYCLE

PARP Inhibitors in Cancer Therapy: Promise, Progress, and Puzzles

(2011) Leif W. Ellisen   CANCER CELL

PARP Inhibitor Treatment in Ovarian and Breast Cancer

(2011) Marcie K. Weil et al.   CURRENT PROBLEMS IN CANCER

The underlying mechanism for the PARP and BRCA synthetic lethality: Clearing up the misunderstandings

(2011) Thomas Helleday   Molecular Oncology

The Ups and Downs of Tannins as Inhibitors of Poly(ADP-Ribose)glycohydrolase

(2011) Christian Blenn et al.   MOLECULES

A Syngeneic Variance Library for Functional Annotation of Human Variation: Application to BRCA2

(2008) T. Hucl et al.   CANCER RESEARCH

Downregulation of Tie2 gene by a novel antitumor sulfolipid, 3'-sulfoquinovosyl-1'-monoacylglycerol, targeting angiogenesis

(2008) Yoko Mori et al.   CANCER SCIENCE