In vitro selection of miltefosine resistance in promastigotes of Leishmania donovani from Nepal: genomic and metabolomic characterization

Experimental Resistance to Drug Combinations in Leishmania donovani: Metabolic and Phenotypic Adaptations

(2015) Maya Berg et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Multi-analytical platform metabolomic approach to study miltefosine mechanism of action and resistance in Leishmania

(2014) Gisele A. B. Canuto et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Treatment failure in leishmaniasis: drug-resistance or another (epi-) phenotype?

(2014) Manu Vanaerschot et al.   Expert Review of Anti-Infective Therapy

Failure of Miltefosine in Visceral Leishmaniasis Is Associated With Low Drug Exposure

(2014) T. P. C. Dorlo et al.   JOURNAL OF INFECTIOUS DISEASES

Spread of Artemisinin Resistance in Plasmodium falciparum Malaria

(2014) Elizabeth A. Ashley et al.   NEW ENGLAND JOURNAL OF MEDICINE

Experimental selection of paromomycin and miltefosine resistance in intracellular amastigotes of Leishmania donovani and L. infantum

(2014) S. Hendrickx et al.   PARASITOLOGY RESEARCH

Comparative transcript expression analysis of miltefosine-sensitive and miltefosine-resistant Leishmania donovani

(2014) Arpita Kulshrestha et al.   PARASITOLOGY RESEARCH

Genome-Wide Stochastic Adaptive DNA Amplification at Direct and Inverted DNA Repeats in the Parasite Leishmania

(2014) Jean-Michel Ubeda et al.   PLOS BIOLOGY

Antimony Resistant Leishmania donovani but Not Sensitive Ones Drives Greater Frequency of Potent T-Regulatory Cells upon Interaction with Human PBMCs: Role of IL-10 and TGF-β in Early Immune Response

(2014) Rajan Guha et al.   PLoS Neglected Tropical Diseases

Epidemiology of visceral leishmaniasis

(2014) Paul Ready   Clinical Epidemiology

In vitro Susceptibility of Leishmania donovani to Miltefosine in Indian Visceral Leishmaniasis

(2013) Vijay Kumar Prajapati et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Increasing Failure of Miltefosine in the Treatment of Kala-azar in Nepal and the Potential Role of Parasite Drug Resistance, Reinfection, or Noncompliance

(2013) Suman Rijal et al.   CLINICAL INFECTIOUS DISEASES

Determination of antiprotozoal drug mechanisms by metabolomics approaches

(2013) DARREN J. CREEK et al.   PARASITOLOGY

Experiments on the role of deleterious mutations as stepping stones in adaptive evolution

(2013) Arthur W. Covert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antimony-resistant but not antimony-sensitive Leishmania donovani up-regulates host IL-10 to overexpress multidrug-resistant protein 1

(2013) B. Mukherjee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A versatile proline/alanine transporter in the unicellular pathogenLeishmania donovaniregulates amino acid homoeostasis and osmotic stress responses

(2012) Ehud Inbar et al.   BIOCHEMICAL JOURNAL

A method to infer positive selection from marker dynamics in an asexual population

(2012) Christopher J. R. Illingworth et al.   BIOINFORMATICS

Efficacy of Miltefosine in the Treatment of Visceral Leishmaniasis in India After a Decade of Use

(2012) S. Sundar et al.   CLINICAL INFECTIOUS DISEASES

Miltefosine: a review of its pharmacology and therapeutic efficacy in the treatment of leishmaniasis

(2012) T. P. C. Dorlo et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

De novo assembly and genotyping of variants using colored de Bruijn graphs

(2012) Zamin Iqbal et al.   NATURE GENETICS

Leishmaniasis Worldwide and Global Estimates of Its Incidence

(2012) Jorge Alvar et al.   PLoS One

Adaptive mechanisms in pathogens: universal aneuploidy in Leishmania

(2012) An Mannaert et al.   TRENDS IN PARASITOLOGY

Multiple Mutations in Heterogeneous Miltefosine-Resistant Leishmania major Population as Determined by Whole Genome Sequencing

(2012) Adriano C. Coelho et al.   PLoS Neglected Tropical Diseases

Drug Susceptibility in Leishmania Isolates Following Miltefosine Treatment in Cases of Visceral Leishmaniasis and Post Kala-Azar Dermal Leishmaniasis

(2012) Vasundhra Bhandari et al.   PLoS Neglected Tropical Diseases

Identification of phospholipid species affected by miltefosine action in Leishmania donovani cultures using LC-ELSD, LC-ESI/MS, and multivariate data analysis

(2011) L. Imbert et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance

(2011) T. Downing et al.   GENOME RESEARCH

Characterisation of antimony-resistant Leishmania donovani isolates: Biochemical and biophysical studies and interaction with host cells

(2011) Rupkatha Mukhopadhyay et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Contribution of proteomics of Leishmania spp. to the understanding of differentiation, drug resistance mechanisms, vaccine and drug development

(2011) Daniel Paape et al.   Journal of Proteomics

Negative Epistasis Between Beneficial Mutations in an Evolving Bacterial Population

(2011) A. I. Khan et al.   SCIENCE

The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data

(2010) A. McKenna et al.   GENOME RESEARCH

A method and server for predicting damaging missense mutations

(2010) Ivan A Adzhubei et al.   NATURE METHODS

Metabolomics to Unveil and Understand Phenotypic Diversity between Pathogen Populations

(2010) Ruben t'Kindt et al.   PLoS Neglected Tropical Diseases

The Sequence Alignment/Map format and SAMtools

(2009) H. Li et al.   BIOINFORMATICS

Multiple Genetic Mechanisms Lead to Loss of Functional TbAT1 Expression in Drug-Resistant Trypanosomes

(2009) Mhairi L. Stewart et al.   EUKARYOTIC CELL

Phospholipid and sphingolipid metabolism in Leishmania

(2009) Kai Zhang et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm

(2009) Prateek Kumar et al.   Nature Protocols

MPEx: A tool for exploring membrane proteins

(2009) Craig Snider et al.   PROTEIN SCIENCE

A generic method for assignment of reliability scores applied to solvent accessibility predictions

(2009) Bent Petersen et al.   BMC STRUCTURAL BIOLOGY

Characterization of an ABCG-Like Transporter from the Protozoan Parasite Leishmania with a Role in Drug Resistance and Transbilayer Lipid Movement

(2008) E. Castanys-Munoz et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY