New Thiazolyl-Pyrazoline Derivatives as Potential Dual EGFR/HER2 Inhibitors: Design, Synthesis, Anticancer Activity Evaluation and In Silico Study

Synthesis and Molecular Docking of Some Novel 3-Thiazolyl-Coumarins as Inhibitors of VEGFR-2 Kinase

(2023) Tariq Z. Abolibda et al.   MOLECULES

1-Benzyl-5-bromo-3-hydrazonoindolin-2-ones as Novel Anticancer Agents: Synthesis, Biological Evaluation and Molecular Modeling Insights

(2023) Tarfah Al-Warhi et al.   MOLECULES

Fragment merging approach for the design of thiazole/thiazolidine clubbed pyrazoline derivatives as anti-inflammatory agents: Synthesis, biopharmacological evaluation and molecular modeling studies

(2023) Mohamed K. Elgohary et al.   BIOORGANIC CHEMISTRY

Novel 2-(5-Aryl-4,5-Dihydropyrazol-1-yl)thiazol-4-One as EGFR Inhibitors: Synthesis, Biological Assessment and Molecular Docking Insights

(2022) Tarfah Al-Warhi et al.   Drug Design Development and Therapy

Can EGFR be a therapeutic target in breast cancer?

(2022) Xiyin Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Discovery of novel thiazolyl-pyrazolines as dual EGFR and VEGFR-2 inhibitors endowed with in vitro antitumor activity towards non-small lung cancer

(2022) Esraa A. Abdelsalam et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Rational Design, Synthesis and Biological Evaluation of Novel Pyrazoline-Based Antiproliferative Agents in MCF-7 Cancer Cells

(2022) Mariam M. Fakhry et al.   Pharmaceuticals

Properties of FDA-approved small molecule protein kinase inhibitors: A 2023 update

(2022) Robert Roskoski   PHARMACOLOGICAL RESEARCH

Pyrazoles and Pyrazolines as Anti-Inflammatory Agents

(2021) Martha Mantzanidou et al.   MOLECULES

Synthesis and antimicrobial, antiproliferative and anti-inflammatory activities of novel 1,3,5-substituted pyrazoline sulphonamides

(2021) Thi-Dan Thach et al.   Arabian Journal of Chemistry

Discovery of New Apoptosis-Inducing Agents for Breast Cancer Based on Ethyl 2-Amino-4,5,6,7-Tetra Hydrobenzo[b]Thiophene-3-Carboxylate: Synthesis, In Vitro, and In Vivo Activity Evaluation

(2020) Emad M. Gad et al.   MOLECULES

Novel 3-substituted coumarins as selective human carbonic anhydrase IX and XII inhibitors: Synthesis, biological and molecular dynamics analysis

(2020) Mohamed A. Abdelrahman et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Thiazolyl-pyrazole derivatives as potential antimycobacterial agents

(2019) Sushma J. Takate et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Transition From Heart Disease to Cancer as the Leading Cause of Death in the United States

(2019) Stephen Sidney et al.   ANNALS OF INTERNAL MEDICINE

Synthesis and biological evaluation of novel xanthine derivatives as potential apoptotic antitumor agents

(2019) Mohamed Hisham et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of some novel pyrazoline‐thiazole hybrids and their antimicrobial activities

(2019) Doaa M. Masoud et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Design, synthesis and biological evaluation of a new series of thiazolyl-pyrazolines as dual EGFR and HER2 inhibitors

(2019) Belgin Sever et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Thiazole-containing compounds as therapeutic targets for cancer therapy

(2019) Prabodh Chander Sharma et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A comprehensive review of protein kinase inhibitors for cancer therapy

(2018) Radhamani Kannaiyan et al.   Expert Review of Anticancer Therapy

Synthesis and anti-proliferative activity of some new quinoline based 4,5-dihydropyrazoles and their thiazole hybrids as EGFR inhibitors

(2018) Riham F. George et al.   BIOORGANIC CHEMISTRY

A BOILED-Egg To Predict Gastrointestinal Absorption and Brain Penetration of Small Molecules

(2016) Antoine Daina et al.   ChemMedChem

Classification of small molecule protein kinase inhibitors based upon the structures of their drug-enzyme complexes

(2016) Robert Roskoski   PHARMACOLOGICAL RESEARCH

Synthesis, biological evaluation and 3D-QSAR study of novel 4,5-dihydro-1H-pyrazole thiazole derivatives as BRAFV600E inhibitors

(2015) Meng-Yue Zhao et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and Evaluation of New Pyrazoline Derivatives as Potential Anticancer Agents

(2015) Muhammed Karabacak et al.   MOLECULES

A historical overview of protein kinases and their targeted small molecule inhibitors

(2015) Robert Roskoski   PHARMACOLOGICAL RESEARCH

Overcoming acquired resistance to anticancer therapy: focus on the PI3K/AKT/mTOR pathway

(2013) Howard A. Burris   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Dabrafenib: First Global Approval

(2013) Anita D. Ballantyne et al.   DRUGS

New pyrazole derivatives containing 1,2,4-triazoles and benzoxazoles as potent antimicrobial and analgesic agents

(2013) A.M. Vijesh et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, molecular docking and evaluation of thiazolyl-pyrazoline derivatives containing benzodioxole as potential anticancer agents

(2012) Hai-Hong Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

EGFR tyrosine kinase inhibition induces autophagy in cancer cells

(2012) Christopher Fung et al.   CANCER BIOLOGY & THERAPY

Synthesis, molecular docking and evaluation of thiazolyl-pyrazoline derivatives as EGFR TK inhibitors and potential anticancer agents

(2011) Peng-Cheng Lv et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Molecular biology in breast cancer: Intrinsic subtypes and signaling pathways

(2011) Pilar Eroles et al.   CANCER TREATMENT REVIEWS

Design and Synthesis of Novel Human Epidermal Growth Factor Receptor 2 (HER2)/Epidermal Growth Factor Receptor (EGFR) Dual Inhibitors Bearing a Pyrrolo[3,2-d]pyrimidine Scaffold

(2011) Tomoyasu Ishikawa et al.   JOURNAL OF MEDICINAL CHEMISTRY

New pyrazoline derivatives and their antidepressant activity

(2010) Zafer Asım Kaplancıklı et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of substituted acridinyl pyrazoline derivatives and their evaluation for anti-inflammatory activity

(2010) Trilok Chandra et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

HER-2 as a Target for Breast Cancer Therapy

(2009) M. Ignatiadis et al.   CLINICAL CANCER RESEARCH

Synthesis and inhibitory activity against human monoamine oxidase of N1-thiocarbamoyl-3,5-di(hetero)aryl-4,5-dihydro-(1 H )-pyrazole derivatives

(2009) Franco Chimenti et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel 2-pyrazoline derivatives as potential antibacterial and antifungal agents

(2009) Suvarna Kini et al.   INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES

Anti-EGFR Therapy: Mechanism and Advances in Clinical Efficacy in Breast Cancer

(2009) John F. Flynn et al.   Journal of Oncology

Preclinical discovery of ixabepilone, a highly active antineoplastic agent

(2008) Francis Y. F. Lee et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

A History of Cancer Chemotherapy

(2008) Vincent T. DeVita et al.   CANCER RESEARCH

Synthesis and antimicrobial evaluation of 1-(benzofuran-2-yl)-4-nitro-3-arylbutan-1-ones and 3-(benzofuran-2-yl)-4,5-dihydro-5-aryl-1-[4-(aryl)-1,3-thiazol-2-yl]-1H-pyrazoles

(2008) Bakr F. Abdel-Wahab et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

FDA Drug Approval Summary: Lapatinib in Combination with Capecitabine for Previously Treated Metastatic Breast Cancer That Overexpresses HER-2

(2008) Q. Ryan et al.   ONCOLOGIST