Oleoylethanolamide facilitates PPARα and TFEB signaling and attenuates Aβ pathology in a mouse model of Alzheimer’s disease

Synthetic PPAR Agonist DTMB Alleviates Alzheimer’s Disease Pathology by Inhibition of Chronic Microglial Inflammation in 5xFAD Mice

(2022) Eunji Oh et al.   Neurotherapeutics

Microglial efferocytosis: Diving into the Alzheimer’s disease gene pool

(2022) Carmen Romero-Molina et al.   NEURON

Plaque-associated human microglia accumulate lipid droplets in a chimeric model of Alzheimer’s disease

(2021) Christel Claes et al.   Molecular Neurodegeneration

Association of plasma and CSF cytochrome P450, soluble epoxide hydrolase, and ethanolamide metabolism with Alzheimer’s disease

(2021) Kamil Borkowski et al.   Alzheimers Research & Therapy

Regulation of PPARα by APP in Alzheimer disease affects the pharmacological modulation of synaptic activity

(2021) Francisco Sáez-Orellana et al.   JCI Insight

PPAR-α Agonist GW7647 Protects Against Oxidative Stress and Iron Deposit via GPx4 in a Transgenic Mouse Model of Alzheimer’s Diseases

(2021) Xiao-Xia Qu et al.   ACS Chemical Neuroscience

Activation of PPARα enhances astroglial uptake and degradation of β-amyloid

(2021) Sumita Raha et al.   Science Signaling

Hippocampal disruptions of synaptic and astrocyte metabolism are primary events of early amyloid pathology in the 5xFAD mouse model of Alzheimer’s disease

(2021) Jens V. Andersen et al.   Cell Death & Disease

Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain

(2020) Julia Marschallinger et al.   NATURE NEUROSCIENCE

TFEB regulates lysosomal exocytosis of tau and its loss of function exacerbates tau pathology and spreading

(2020) Yin Xu et al.   MOLECULAR PSYCHIATRY

Alzheimer’s Disease, a Lipid Story: Involvement of Peroxisome Proliferator-Activated Receptor α

(2020) Francisco Sáez-Orellana et al.   Cells

Untargeted lipidomics reveals progression of early Alzheimer’s disease in APP/PS1 transgenic mice

(2020) Xueju Zhang et al.   Scientific Reports

An epoxide hydrolase inhibitor reduces neuroinflammation in a mouse model of Alzheimer’s disease

(2020) Anamitra Ghosh et al.   Science Translational Medicine

Activation of PPARA-mediated autophagy reduces Alzheimer disease-like pathology and cognitive decline in a murine model

(2019) Rongcan Luo et al.   Autophagy

Molecular actions of PPARα in lipid metabolism and inflammation

(2018) Nadia Bougarne et al.   ENDOCRINE REVIEWS

TFEB enhances astroglial uptake of extracellular tau species and reduces tau spreading

(2018) Heidi Martini-Stoica et al.   JOURNAL OF EXPERIMENTAL MEDICINE

mTOR-dependent phosphorylation controls TFEB nuclear export

(2018) Gennaro Napolitano et al.   Nature Communications

Complement C3aR Inactivation Attenuates Tau Pathology and Reverses an Immune Network Deregulated in Tauopathy Models and Alzheimer’s Disease

(2018) Alexandra Litvinchuk et al.   NEURON

Cinnamic acid activates PPARα to stimulate Lysosomal biogenesis and lower Amyloid plaque pathology in an Alzheimer's disease mouse model

(2018) Sujyoti Chandra et al.   NEUROBIOLOGY OF DISEASE

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases

(2017) Michela Palmieri et al.   Nature Communications

TREM2 promotes Aβ phagocytosis by upregulating C/EBPα-dependent CD36 expression in microglia

(2017) Su-Man Kim et al.   Scientific Reports

Targeting metastasis-initiating cells through the fatty acid receptor CD36

(2016) Gloria Pascual et al.   NATURE

Identification and characterization of PPARα ligands in the hippocampus

(2016) Avik Roy et al.   Nature Chemical Biology

Localization of PPAR isotypes in the adult mouse and human brain

(2016) Anna Warden et al.   Scientific Reports

Reduction of Glucose Metabolism in Olfactory Bulb is an Earlier Alzheimer's Disease-related Biomarker in 5XFAD Mice

(2015) Xiao-Chun Chen et al.   CHINESE MEDICAL JOURNAL

Activation of Peroxisome Proliferator-activated Receptor α Induces Lysosomal Biogenesis in Brain Cells

(2015) Arunava Ghosh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MiT/TFE transcription factors are activated during mitophagy downstream of Parkin and Atg5

(2015) Catherine L. Nezich et al.   JOURNAL OF CELL BIOLOGY

Neuronal-Targeted TFEB Accelerates Lysosomal Degradation of APP, Reducing A  Generation and Amyloid Plaque Pathogenesis

(2015) Q. Xiao et al.   JOURNAL OF NEUROSCIENCE

Activation of peroxisome proliferator-activated receptor α stimulates ADAM10-mediated proteolysis of APP

(2015) Grant T. Corbett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective clearance of aberrant tau proteins and rescue of neurotoxicity by transcription factor EB

(2014) V. A. Polito et al.   EMBO Molecular Medicine

Enhancing Astrocytic Lysosome Biogenesis Facilitates A  Clearance and Attenuates Amyloid Plaque Pathogenesis

(2014) Q. Xiao et al.   JOURNAL OF NEUROSCIENCE

Pan-PPAR Modulation Effectively Protects APP/PS1 Mice from Amyloid Deposition and Cognitive Deficits

(2014) Markus P. Kummer et al.   MOLECULAR NEUROBIOLOGY

Cell metabolism: Autophagy transcribed

(2014) Carmine Settembre et al.   NATURE

TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop

(2013) Carmine Settembre et al.   NATURE CELL BIOLOGY

Signals from the lysosome: a control centre for cellular clearance and energy metabolism

(2013) Carmine Settembre et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Peroxisome proliferator-activated receptor (PPAR)β/δ, a possible nexus of PPARα- and PPARγ-dependent molecular pathways in neurodegenerative diseases: Review and novel hypotheses

(2013) Stepan Aleshin et al.   NEUROCHEMISTRY INTERNATIONAL

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Peroxisome Proliferator-Activated Receptor (PPAR)-  Positively Controls and PPAR  Negatively Controls Cyclooxygenase-2 Expression in Rat Brain Astrocytes through a Convergence on PPAR /  via Mutual Control of PPAR Expression Levels

(2009) S. Aleshin et al.   MOLECULAR PHARMACOLOGY

CD36 gene deletion decreases oleoylethanolamide levels in small intestine of free-feeding mice

(2009) Ana Guijarro et al.   PHARMACOLOGICAL RESEARCH