Polyphenols Targeting MAP Kinase Signaling Pathway in Neurological Diseases: Understanding Molecular Mechanisms and Therapeutic Targets

Paraneoplastic Neurological Syndromes of the Central Nervous System: Pathophysiology, Diagnosis, and Treatment

(2023) Luca Marsili et al.   Biomedicines

Multifaceted role of polyphenols in the treatment and management of neurodegenerative diseases

(2022) Fahadul Islam et al.   CHEMOSPHERE

A renewed concept on the MAPK signaling pathway in cancers: Polyphenols as a choice of therapeutics

(2022) Juhaer Anjum et al.   PHARMACOLOGICAL RESEARCH

Effects of catechin on a rodent model of autism spectrum disorder: implications for the role of nitric oxide in neuroinflammatory pathway

(2021) Rishab Mehta et al.   PSYCHOPHARMACOLOGY

Luteolin and Apigenin Attenuate LPS-Induced Astrocyte Activation and Cytokine Production by Targeting MAPK, STAT3, and NF-κB Signaling Pathways

(2020) Denis Nchang Che et al.   INFLAMMATION

Ferulic Acid Ameliorates MPP+/MPTP-Induced Oxidative Stress via ERK1/2-Dependent Nrf2 Activation: Translational Implications for Parkinson Disease Treatment

(2020) Xu Li et al.   MOLECULAR NEUROBIOLOGY

Promising Polyphenols in Parkinson’s Disease Therapeutics

(2020) Ashish Singh et al.   NEUROCHEMICAL RESEARCH

Neuroprotective Effect of Chlorogenic Acid on Mitochondrial Dysfunction-Mediated Apoptotic Death of DA Neurons in a Parkinsonian Mouse Model

(2020) Saumitra Sen Singh et al.   Oxidative Medicine and Cellular Longevity

Resveratrol Preincubation Enhances the Therapeutic Efficacy of hUC-MSCs by Improving Cell Migration and Modulating Neuroinflammation Mediated by MAPK Signaling in a Mouse Model of Alzheimer’s Disease

(2020) Xinxin Wang et al.   Frontiers in Cellular Neuroscience

Effect of Luteolin and Apigenin on the Production of Il-31 and Il-33 in Lipopolysaccharides-Activated Microglia Cells and Their Mechanism of Action

(2020) Denis Nchang Che et al.   Nutrients

MAP/ERK Signaling in Developing Cognitive and Emotional Function and Its Effect on Pathological and Neurodegenerative Processes

(2020) Héctor Albert-Gascó et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

SkQ1 Suppresses the p38 MAPK Signaling Pathway Involved in Alzheimer’s Disease-Like Pathology in OXYS Rats

(2020) Natalia A. Muraleva et al.   Antioxidants

Deciphering the Pharmacological Properties of Methanol Extract of Psychotria calocarpa Leaves by In Vivo, In Vitro and In Silico Approaches

(2020) Tahmina Akter Bristy et al.   Pharmaceuticals

Map kinase signaling as therapeutic target for neurodegeneration

(2020) Touqeer Ahmed et al.   PHARMACOLOGICAL RESEARCH

Novel Therapeutic Delivery of Nanocurcumin in Central Nervous System Related Disorders

(2020) Elisa Panzarini et al.   Nanomaterials

Targeting MAPK Pathways by Naringenin Modulates Microglia M1/M2 Polarization in Lipopolysaccharide-Stimulated Cultures

(2019) Bei Zhang et al.   Frontiers in Cellular Neuroscience

The natural plant flavonoid apigenin is a strong antioxidant that effectively delays peripheral neurodegenerative processes

(2019) Muwoong Kim et al.   ANATOMICAL SCIENCE INTERNATIONAL

Baicalein administered in the subacute phase ameliorates ischemia-reperfusion-induced brain injury by reducing neuroinflammation and neuronal damage

(2019) Shilun Yang et al.   BIOMEDICINE & PHARMACOTHERAPY

A Novel Quinolyl‐Substituted Analogue of Resveratrol Inhibits LPS‐Induced Inflammatory Responses in Microglial Cells by Blocking the NF‐κB/MAPK Signaling Pathways

(2019) Yue Hou et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Effects of curcumin on mitochondria in neurodegenerative diseases

(2019) Hossein Bagheri et al.   BIOFACTORS

Dietary Polyphenols: A Multifactorial Strategy to Target Alzheimer’s Disease

(2019) Sudip Dhakal et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Scutellarin Exerts Anti-Inflammatory Effects in Activated Microglia/Brain Macrophage in Cerebral Ischemia and in Activated BV-2 Microglia Through Regulation of MAPKs Signaling Pathway

(2019) Hao-Lun Chen et al.   NEUROMOLECULAR MEDICINE

Curcumin protects cortical neurons against oxygen and glucose deprivation/reoxygenation injury through flotillin-1 and extracellular signal-regulated kinase1/2 pathway

(2018) Zhengyu Lu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The valproic acid-induced rodent model of autism

(2018) Chiara Nicolini et al.   EXPERIMENTAL NEUROLOGY

The Effect of BSA-Based Curcumin Nanoparticles on Memory and Hippocampal MMP-2, MMP-9, and MAPKs in Adult Mice

(2018) Roksana SoukhakLari et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Curcumin attenuates chronic intermittent hypoxia-induced brain injuries by inhibiting AQP4 and p38 MAPK pathway

(2018) Bo Wang et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Role of p38/MAPKs in Alzheimer’s disease: implications for amyloid beta toxicity targeted therapy

(2018) Ghazaleh Kheiri et al.   REVIEWS IN THE NEUROSCIENCES

MicroRNA in Alzheimer’s disease revisited: implications for major neuropathological mechanisms

(2018) Reihaneh Dehghani et al.   REVIEWS IN THE NEUROSCIENCES

Dietary polyphenols: A novel strategy to modulate microbiota-gut-brain axis

(2018) Diana Serra et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

Myricetin prevents dopaminergic neurons from undergoing neuroinflammation-mediated degeneration in a lipopolysaccharide-induced Parkinson’s disease model

(2018) Bingxu Huang et al.   Journal of Functional Foods

Polyphenols in Parkinson’s Disease: A Systematic Review of In Vivo Studies

(2018) Małgorzata Kujawska et al.   Nutrients

Amelioration of oxidative stress in differentiated neuronal cells by rutin regulated by a concentration switch

(2018) Banudevi Sivanantham et al.   BIOMEDICINE & PHARMACOTHERAPY

Autism Spectrum Disorders: Potential Neuro-Psychopharmacotherapeutic Plant-Based Drugs

(2018) Kendy Eduardo Urdaneta et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Genetically Engineered Resveratrol-Enriched Rice Inhibits Neuroinflammation in Lipopolysaccharide-Activated BV2 Microglia Via Downregulating Mitogen-Activated Protein Kinase-Nuclear Factor Kappa B Signaling Pathway

(2018) Lalita Subedi et al.   Oxidative Medicine and Cellular Longevity

Chronic impairment of ERK signaling in glutamatergic neurons of the forebrain does not affect spatial memory retention and LTP in the same manner as acute blockade of the ERK pathway

(2017) Joseph Vithayathil et al.   HIPPOCAMPUS

Anti-neuroinflammatory effect of curcumin on Pam3CSK4-stimulated microglial cells

(2017) Meiling Jin et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Neuroprotective and Anti-Inflammatory Activities of Allyl Isothiocyanate through Attenuation of JNK/NF-κB/TNF-α Signaling

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neuroprotective Effect of Curcumin Against Cerebral Ischemia-Reperfusion Via Mediating Autophagy and Inflammation

(2017) Lifa Huang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer’s disease

(2017) Charbel Moussa et al.   Journal of Neuroinflammation

Luteolin Inhibits Fibrillary β-Amyloid1–40-Induced Inflammation in a Human Blood-Brain Barrier Model by Suppressing the p38 MAPK-Mediated NF-κB Signaling Pathways

(2017) Jun-Xia Zhang et al.   MOLECULES

Neuroprotective properties of icariin in MPTP-induced mouse model of Parkinson's disease: Involvement of PI3K/Akt and MEK/ERK signaling pathways

(2017) Wen-Fang Chen et al.   PHYTOMEDICINE

Neurotransmission systems in Parkinson’s disease

(2017) Hossein Sanjari Moghaddam et al.   REVIEWS IN THE NEUROSCIENCES

Rutin attenuates isoflurane-induced neuroapoptosis via modulating JNK and p38 MAPK pathways in the hippocampi of neonatal rats

(2017) Wei Li et al.   Experimental and Therapeutic Medicine

Rutin hydrate ameliorates cadmium chloride-induced spatial memory loss and neural apoptosis in rats by enhancing levels of acetylcholine, inhibiting JNK and ERK1/2 activation and activating mTOR signalling

(2017) Ghada A. Abdel-Aleem et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

The Polyphenol Oleuropein Aglycone Modulates the PARP1-SIRT1 Interplay: An In Vitro and In Vivo Study

(2016) Ilaria Luccarini et al.   JOURNAL OF ALZHEIMERS DISEASE

Ameliorating effect of luteolin on memory impairment in an Alzheimer's disease model

(2016) HUIMIN WANG et al.   Molecular Medicine Reports

Genistein alleviates lead-induced neurotoxicity in vitro and in vivo : Involvement of multiple signaling pathways

(2016) Peng Su et al.   NEUROTOXICOLOGY

Resveratrol protects CA1 neurons against focal cerebral ischemic reperfusion-induced damage via the ERK-CREB signaling pathway in rats

(2016) Zhen Li et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Quercetin Protects against Okadaic Acid-Induced Injury via MAPK and PI3K/Akt/GSK3β Signaling Pathways in HT22 Hippocampal Neurons

(2016) Wei Jiang et al.   PLoS One

Pathway Network Analyses for Autism Reveal Multisystem Involvement, Major Overlaps with Other Diseases and Convergence upon MAPK and Calcium Signaling

(2016) Ya Wen et al.   PLoS One

Silibinin suppresses astroglial activation in a mouse model of acute Parkinson׳s disease by modulating the ERK and JNK signaling pathways

(2015) Yujeong Lee et al.   BRAIN RESEARCH

Carnosic acid protects against 6-hydroxydopamine-induced neurotoxicity in in vivo and in vitro model of Parkinson’s disease: Involvement of antioxidative enzymes induction

(2015) Chi-Rei Wu et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Resveratrol attenuates hypoxia-induced neurotoxicity through inhibiting microglial activation

(2015) Qun Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Rutin, A Natural Flavonoid Protects PC12 Cells Against Sodium Nitroprusside-Induced Neurotoxicity Through Activating PI3K/Akt/mTOR and ERK1/2 Pathway

(2015) Rikang Wang et al.   NEUROCHEMICAL RESEARCH

Resveratrol neuroprotection in stroke and traumatic CNS injury

(2015) Mary S. Lopez et al.   NEUROCHEMISTRY INTERNATIONAL

Curcumin inhibits Aβ-induced microglial inflammatory responses in vitro: Involvement of ERK1/2 and p38 signaling pathways

(2015) Xiaolei Shi et al.   NEUROSCIENCE LETTERS

Protection by genistein on cortical neurons against oxidative stress injury via inhibition of NF-kappaB, JNK and ERK signaling pathway

(2015) Yisong Qian et al.   PHARMACEUTICAL BIOLOGY

Vitexin protects brain against ischemia/reperfusion injury via modulating mitogen-activated protein kinase and apoptosis signaling in mice

(2015) Yanan Wang et al.   PHYTOMEDICINE

Pterostilbene exerts anti-neuroinflammatory effect on lipopolysaccharide-activated microglia via inhibition of MAPK signalling pathways

(2015) Yue Hou et al.   Journal of Functional Foods

Transient Blockade of ERK Phosphorylation in the Critical Period Causes Autistic Phenotypes as an Adult in Mice

(2015) Shinya Yufune et al.   Scientific Reports

Characterizing autism spectrum disorders by key biochemical pathways

(2015) Megha Subramanian et al.   Frontiers in Neuroscience

Curcumin Improves Amyloid β-Peptide (1-42) Induced Spatial Memory Deficits through BDNF-ERK Signaling Pathway

(2015) Lu Zhang et al.   PLoS One

Luteolin and Apigenin Attenuate 4-Hydroxy-2-Nonenal-Mediated Cell Death through Modulation of UPR, Nrf2-ARE and MAPK Pathways in PC12 Cells

(2015) Pei-Shan Wu et al.   PLoS One

Tiliroside, a dietary glycosidic flavonoid, inhibits TRAF-6/NF-κB/p38-mediated neuroinflammation in activated BV2 microglia

(2014) Ravikanth Velagapudi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Activation of BV2 microglia by lipopolysaccharide triggers an inflammatory reaction in PC12 cell apoptosis through a toll-like receptor 4-dependent pathway

(2014) Xiao-jing Dai et al.   CELL STRESS & CHAPERONES

Tangeretin exerts anti-neuroinflammatory effects via NF-κB modulation in lipopolysaccharide-stimulated microglial cells

(2014) Zunpeng Shu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Pinocembrin improves cognition and protects the neurovascular unit in Alzheimer related deficits

(2014) Rui Liu et al.   NEUROBIOLOGY OF AGING

Rutin from Dendropanax morbifera Leveille Protects Human Dopaminergic Cells Against Rotenone Induced Cell Injury Through Inhibiting JNK and p38 MAPK Signaling

(2014) Se-Eun Park et al.   NEUROCHEMICAL RESEARCH

Curcumin attenuates ischemia-like injury induced IL-1β elevation in brain microvascular endothelial cells via inhibiting MAPK pathways and nuclear factor-κB activation

(2014) Hua-jiang Dong et al.   NEUROLOGICAL SCIENCES

Long-Term Memory Deficits are Associated with Elevated Synaptic ERK1/2 Activation and Reversed by mGluR5 Antagonism in an Animal Model of Autism

(2014) Ronald R Seese et al.   NEUROPSYCHOPHARMACOLOGY

A p38 MAPK-Mediated Alteration of COX-2/PGE2 Regulates Immunomodulatory Properties in Human Mesenchymal Stem Cell Aging

(2014) Kyung-Rok Yu et al.   PLoS One

Resveratrol counteracts lipopolysaccharide-mediated microglial inflammation by modulating a SOCS-1 dependent signaling pathway

(2014) Teresa Dragone et al.   TOXICOLOGY IN VITRO

Luteolin inhibits SH-SY5Y cell apoptosis through suppression of the nuclear transcription factor-κB, mitogen-activated protein kinase and protein kinase B pathways in lipopolysaccharide-stimulated cocultured BV2 cells

(2014) LIHONG ZHU et al.   Experimental and Therapeutic Medicine

Baicalein attenuates astroglial activation in the 1-methyl-4-phenyl-1,2,3,4-tetrahydropyridine-induced Parkinson's disease model by downregulating the activations of nuclear factor-κB, ERK, and JNK

(2013) Eunjin Lee et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Neurodegeneration in Streptozotocin-Induced Diabetic Rats Is Attenuated by Treatment with Resveratrol

(2013) Yu-Hong Jing et al.   NEUROENDOCRINOLOGY

Rutin activates the MAPK pathway and BDNF gene expression on beta-amyloid induced neurotoxicity in rats

(2013) Sahar Moghbelinejad et al.   TOXICOLOGY LETTERS

Natural polyphenols against neurodegenerative disorders: Potentials and pitfalls

(2012) Azadeh Ebrahimi et al.   AGEING RESEARCH REVIEWS

Protective effect of celastrol in rat cerebral ischemia model: Down-regulating p-JNK, p-c-Jun and NF-κB

(2012) Yanhua Li et al.   BRAIN RESEARCH

Curcumin Inhibits Glutamate Release from Rat Prefrontal Nerve Endings by Affecting Vesicle Mobilization

(2012) Tzu Yu Lin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Resveratrol preconditioning modulates inflammatory response in the rat hippocampus following global cerebral ischemia

(2012) Fabrício Simão et al.   NEUROCHEMISTRY INTERNATIONAL

Resveratrol Inhibits Inflammatory Responses via the Mammalian Target of Rapamycin Signaling Pathway in Cultured LPS-Stimulated Microglial Cells

(2012) Lian-Mei Zhong et al.   PLoS One

Synaptic Dysfunction in Neurodevelopmental Disorders Associated with Autism and Intellectual Disabilities

(2012) H. Y. Zoghbi et al.   Cold Spring Harbor Perspectives in Biology

Kaempferol acts through mitogen-activated protein kinases and protein kinase B/AKT to elicit protection in a model of neuroinflammation in BV2 microglial cells

(2011) SE Park et al.   BRITISH JOURNAL OF PHARMACOLOGY

Loss of Tsc1 In Vivo Impairs Hippocampal mGluR-LTD and Increases Excitatory Synaptic Function

(2011) H. S. Bateup et al.   JOURNAL OF NEUROSCIENCE

Myricetin attenuated MPP+-induced cytotoxicity by anti-oxidation and inhibition of MKK4 and JNK activation in MES23.5 cells

(2011) Kai Zhang et al.   NEUROPHARMACOLOGY

Mechanisms and functions of p38 MAPK signalling

(2010) Ana Cuadrado et al.   BIOCHEMICAL JOURNAL

Pathological roles of MAPK signaling pathways in human diseases

(2010) Eun Kyung Kim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Resveratrol differentially modulates inflammatory responses of microglia and astrocytes

(2010) Xiaofeng Lu et al.   Journal of Neuroinflammation

Cordycepin induces apoptosis by enhancing JNK and p38 kinase activity and increasing the protein expression of Bcl-2 pro-apoptotic molecules

(2010) Wei He et al.   Journal of Zhejiang University-SCIENCE B

Apigenin protects HT22 murine hippocampal neuronal cells against endoplasmic reticulum stress-induced apoptosis

(2010) A Young Choi et al.   NEUROCHEMISTRY INTERNATIONAL

Chrysin suppresses LPS-stimulated proinflammatory responses by blocking NF-κB and JNK activations in microglia cells

(2010) Sang Keun Ha et al.   NEUROSCIENCE LETTERS

Demethoxycurcumin, a natural derivative of curcumin attenuates LPS-induced pro-inflammatory responses through down-regulation of intracellular ROS-related MAPK/NF-κB signaling pathways in N9 microglia induced by lipopolysaccharide

(2009) Lijia Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The genetic and neurobiologic compass points toward common signaling dysfunctions in autism spectrum disorders

(2009) Pat Levitt et al.   JOURNAL OF CLINICAL INVESTIGATION

MAPK signaling pathways in the regulation of hematopoiesis

(2009) Christian R. Geest et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Green Tea (-)-Epigallocatechin-3-Gallate Inhibits β-Amyloid-Induced Cognitive Dysfunction through Modification of Secretase Activity via Inhibition of ERK and NF-κB Pathways in Mice

(2009) Jae Woong Lee et al.   JOURNAL OF NUTRITION

Curcumin produces neuroprotective effects via activating brain-derived neurotrophic factor/TrkB-dependent MAPK and PI-3K cascades in rodent cortical neurons

(2009) Rui Wang et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Attenuation of oxidative neuronal cell death by coffee phenolic phytochemicals

(2008) Eun Sun Cho et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Ginkgolides protect PC12 cells against hypoxia-induced injury by p42/p44 MAPK pathway-dependent upregulation of HIF-1α expression and HIF-1DNA-binding activity

(2007) Zhu Li et al.   JOURNAL OF CELLULAR BIOCHEMISTRY