CDK12 loss inhibits cell proliferation by regulating TBK1 in non-small cell lung cancer cells

Prognostic value of genomic mutations in metastatic prostate cancer

(2023) Honghui Zhu et al.   Heliyon

Cancer statistics, 2022

(2022) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

The role of TBK1 in cancer pathogenesis and anticancer immunity

(2022) Austin P. Runde et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Discovery of a Highly Potent and Selective Dual PROTAC Degrader of CDK12 and CDK13

(2022) Jianzhang Yang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Stable CDK12 Knock-Out Ovarian Cancer Cells Do Not Show Increased Sensitivity to Cisplatin and PARP Inhibitor Treatment

(2022) Rosaria Chilà et al.   Frontiers in Oncology

CDK12 regulates co-transcriptional splicing and RNA turnover in human cells

(2022) Brian Magnuson et al.   iScience

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

The ever‐increasing importance of cancer as a leading cause of premature death worldwide

(2021) Freddie Bray et al.   CANCER

Profiling of 520 Candidate Genes in 50 Surgically Treated Chinese Small Cell Lung Cancer Patients

(2021) Ting Yuan et al.   Frontiers in Oncology

Dissecting the Pol II transcription cycle and derailing cancer with CDK inhibitors

(2020) Pabitra K. Parua et al.   Nature Chemical Biology

Radiotherapy treatment for lung cancer: Current status and future directions

(2020) Shalini K. Vinod et al.   RESPIROLOGY

Targeting CDK12 for cancer therapy: function, mechanism, and drug discovery

(2020) Hui Liu et al.   CANCER RESEARCH

CDK12 Deficiency and the Immune Microenvironment in Prostate Cancer

(2020) Tamara L. Lotan et al.   CLINICAL CANCER RESEARCH

Quantitative mass spectrometry to interrogate proteomic heterogeneity in metastatic lung adenocarcinoma and validate a novel somatic mutation CDK12-G879V

(2019) Xu Zhang et al.   MOLECULAR & CELLULAR PROTEOMICS

Therapeutic Targeting of CDK12/CDK13 in Triple-Negative Breast Cancer

(2019) Victor Quereda et al.   CANCER CELL

CDK12 Promotes Breast Cancer Progression and Maintains Stemness by Activating c-myc/β-catenin Signaling

(2019) Fang Peng et al.   CURRENT CANCER DRUG TARGETS

CDK12 Mutation in Advanced Prostate Cancer: A Marker for Clinical Subtype?

(2019) Xiao Wang et al.   EUROPEAN UROLOGY

Inactivation of CDK12 Delineates a Distinct Immunogenic Class of Advanced Prostate Cancer

(2018) Yi-Mi Wu et al.   CELL

CDK12 regulates alternative last exon mRNA splicing and promotes breast cancer cell invasion

(2017) Jerry F. Tien et al.   NUCLEIC ACIDS RESEARCH

Characterization of Human Cyclin-Dependent Kinase 12 (CDK12) and CDK13 Complexes in C-Terminal Domain Phosphorylation, Gene Transcription, and RNA Processing

(2015) Kaiwei Liang et al.   MOLECULAR AND CELLULAR BIOLOGY

Ovarian carcinoma CDK12 mutations misregulate expression of DNA repair genes via deficient formation and function of the Cdk12/CycK complex

(2015) Kingsley M. Ekumi et al.   NUCLEIC ACIDS RESEARCH

Clinical challenges in targeting anaplastic lymphoma kinase in advanced non-small cell lung cancer

(2014) Namrata Vijayvergia et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Ovarian Cancer-associated Mutations Disable Catalytic Activity of CDK12, a Kinase That Promotes Homologous Recombination Repair and Resistance to Cisplatin and Poly(ADP-ribose) Polymerase Inhibitors

(2014) Poorval M. Joshi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The structure and substrate specificity of human Cdk12/Cyclin K

(2014) Christian A. Bösken et al.   Nature Communications

Cyclin-dependent kinases

(2014) Marcos Malumbres   GENOME BIOLOGY

Cdks, cyclins and CKIs: roles beyond cell cycle regulation

(2013) S. Lim et al.   DEVELOPMENT

The cyclin K/Cdk12 complex

(2012) Dalibor Blazek   CELL CYCLE