Inhibition of hyaluronan synthesis prevents β-cell loss in obesity-associated type 2 diabetes

Hyaluronan synthesis inhibition impairs antigen presentation and delays transplantation rejection

(2020) Payton L. Marshall et al.   MATRIX BIOLOGY

4-Methylumbelliferyl glucuronide contributes to hyaluronan synthesis inhibition

(2019) Nadine Nagy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CD44 contributes to hyaluronan-mediated insulin resistance in skeletal muscle of high fat-fed C57BL/6 mice

(2019) Annie Hasib et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

CD44 variant inhibits insulin secretion in pancreatic β cells by attenuating LAT1-mediated amino acid uptake

(2018) Nana Kobayashi et al.   Scientific Reports

Hyaluronan levels are increased systemically in human type 2 but not type 1 diabetes independently of glycemic control

(2018) Nadine Nagy et al.   MATRIX BIOLOGY

Age-dependent human β cell proliferation induced by glucagon-like peptide 1 and calcineurin signaling

(2017) Chunhua Dai et al.   JOURNAL OF CLINICAL INVESTIGATION

Hyaluronan coating improves liver engraftment of transplanted human biliary tree stem/progenitor cells

(2017) Lorenzo Nevi et al.   Stem Cell Research & Therapy

The pharmacokinetics and dosing of oral 4-methylumbelliferone for inhibition of hyaluronan synthesis in mice

(2016) H. F. Kuipers et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Hyaluronan synthesis is necessary for autoreactive T-cell trafficking, activation, and Th1 polarization

(2016) Hedwich F. Kuipers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The receptor CD44 is associated with systemic insulin resistance and proinflammatory macrophages in human adipose tissue

(2015) Li Fen Liu et al.   DIABETOLOGIA

Inhibition of hyaluronan synthesis restores immune tolerance during autoimmune insulitis

(2015) Nadine Nagy et al.   JOURNAL OF CLINICAL INVESTIGATION

Genetics of Type 2 Diabetes—Pitfalls and Possibilities

(2015) Rashmi Prasad et al.   Genes

4-Methylumbelliferone Treatment and Hyaluronan Inhibition as a Therapeutic Strategy in Inflammation, Autoimmunity, and Cancer

(2015) Nadine Nagy et al.   Frontiers in Immunology

Key Roles of Hyaluronan and Its CD44 Receptor in the Stemness and Survival of Cancer Stem Cells

(2015) Theerawut Chanmee et al.   Frontiers in Oncology

Can CD44 Be a Mediator of Cell Destruction? The Challenge of Type 1 Diabetes

(2015) Nathalie Assayag-Asherie et al.   PLoS One

Hyperglycemia, intracellular hyaluronan synthesis, cyclin D3 and autophagy

(2014) Aimin Wang et al.   Autophagy

Hyaluronan and Hyaluronan-Binding Proteins Accumulate in Both Human Type 1 Diabetic Islets and Lymphoid Tissues and Associate With Inflammatory Cells in Insulitis

(2014) M. Bogdani et al.   DIABETES

Anti-CD44 Antibody Treatment Lowers Hyperglycemia and Improves Insulin Resistance, Adipose Inflammation, and Hepatic Steatosis in Diet-Induced Obese Mice

(2014) Keiichi Kodama et al.   DIABETES

Targeting inflammation in the treatment of type 2 diabetes: time to start

(2014) Marc Y. Donath   NATURE REVIEWS DRUG DISCOVERY

Treatment of Hyaluronan Accumulation Ameliorates High-Fat Diet-Induced Insulin Resistance in Mice

(2013) P. Fogelstrand et al.   DIABETES

TSG-6 Produced by hMSCs Delays the Onset of Autoimmune Diabetes by Suppressing Th1 Development and Enhancing Tolerogenicity

(2013) D. J. Kota et al.   DIABETES

Hyaluronan Accumulates With High-Fat Feeding and Contributes to Insulin Resistance

(2013) L. Kang et al.   DIABETES

IL-10 Induction from Implants Delivering Pancreatic Islets and Hyaluronan

(2013) Paul L. Bollyky et al.   Journal of Diabetes Research

Heparanase and Autoimmune Diabetes

(2013) Charmaine J. Simeonovic et al.   Frontiers in Immunology

Diabetes Mellitus and the β Cell: The Last Ten Years

(2012) Frances M. Ashcroft et al.   CELL

Hyaluronan and Hyaluronan Binding Proteins Are Normal Components of Mouse Pancreatic Islets and Are Differentially Expressed by Islet Endocrine Cell Types

(2012) Rebecca L. Hull et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Expression-based genome-wide association study links the receptor CD44 in adipose tissue with type 2 diabetes

(2012) K. Kodama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Survivin Is a Novel Target of CD44-Promoted Breast Tumor Invasion

(2011) Mohamed E. Abdraboh et al.   AMERICAN JOURNAL OF PATHOLOGY

Improved Postprandial Glycemic Control in Patients with Type 2 Diabetes from Subcutaneous Injection of Insulin Lispro with Hyaluronidase

(2011) Marcus Hompesch et al.   Diabetes Technology & Therapeutics

Heparan sulfate and heparanase play key roles in mouse β cell survival and autoimmune diabetes

(2011) Andrew F. Ziolkowski et al.   JOURNAL OF CLINICAL INVESTIGATION

Hyaluronan as an Immune Regulator in Human Diseases

(2011) Dianhua Jiang et al.   PHYSIOLOGICAL REVIEWS

Islet Amyloid Polypeptide, Islet Amyloid, and Diabetes Mellitus

(2011) Per Westermark et al.   PHYSIOLOGICAL REVIEWS

Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse

(2010) Paul L Bollyky et al.   Cellular & Molecular Immunology

Diabetes and apoptosis: lipotoxicity

(2009) Christine M. Kusminski et al.   APOPTOSIS

Perinatal survivin is essential for the establishment of pancreatic beta cell mass in mice

(2009) X. Wu et al.   DIABETOLOGIA

4-Methylumbelliferone inhibits hyaluronan synthesis by depletion of cellular UDP-glucuronic acid and downregulation of hyaluronan synthase 2 and 3

(2009) Anne Kultti et al.   EXPERIMENTAL CELL RESEARCH

The Toll-Like Receptor Signaling Molecule Myd88 Contributes to Pancreatic Beta-Cell Homeostasis in Response to Injury

(2009) Paul L. Bollyky et al.   PLoS One

CD44-specific antibody treatment and CD44 deficiency exert distinct effects on leukocyte recruitment in experimental arthritis

(2008) G. Hutas et al.   BLOOD

Primary Murine Airway Smooth Muscle Cells Exposed to Poly(I,C) or Tunicamycin Synthesize a Leukocyte-adhesive Hyaluronan Matrix

(2008) Mark E. Lauer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY