Cytokine storm mitigation for exogenous immune agonists

Quantitative Systems Pharmacology approaches for Immuno‐oncology: adding virtual patients to the development paradigm

(2020) Vijayalakshmi Chelliah et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

The pathogenesis and treatment of the `Cytokine Storm' in COVID-19

(2020) Qing Ye et al.   JOURNAL OF INFECTION

Efficacy and safety of anti-CD19 CAR T-cell therapy in 110 patients with B-cell acute lymphoblastic leukemia with high-risk features

(2020) Xian Zhang et al.   Blood Advances

Cytokine Storm

(2020) David C. Fajgenbaum et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Translational Quantitative Systems Pharmacology Model for CD3 Bispecific Molecules: Application to Quantify T Cell-Mediated Tumor Cell Killing by P-Cadherin LP DART®

(2019) Alison Betts et al.   AAPS Journal

A Modeling Framework to Characterize Cytokine Release upon T‐Cell–Engaging Bispecific Antibody Treatment: Methodology and Opportunities

(2019) Xiaoying Chen et al.   CTS-Clinical and Translational Science

Cancer cell population growth kinetics at low densities deviate from the exponential growth model and suggest an Allee effect

(2019) Kaitlyn E. Johnson et al.   PLOS BIOLOGY

Grading of cytokine release syndrome associated with the CAR T cell therapy tisagenlecleucel

(2018) David Porter et al.   Journal of Hematology & Oncology

Unanswered questions about the 1918 influenza pandemic: origin, pathology, and the virus itself

(2018) John S Oxford et al.   LANCET INFECTIOUS DISEASES

Models of cytokine dynamics in the inflammatory response of viral zoonotic infectious diseases

(2018) Wenjing Zhang et al.   MATHEMATICAL MEDICINE AND BIOLOGY-A JOURNAL OF THE IMA

CAR T cell–induced cytokine release syndrome is mediated by macrophages and abated by IL-1 blockade

(2018) Theodoros Giavridis et al.   NATURE MEDICINE

Long-Term Follow-up of CD19 CAR Therapy in Acute Lymphoblastic Leukemia

(2018) Jae H. Park et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia

(2018) Shannon L. Maude et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cytokine release syndrome

(2018) Alexander Shimabukuro-Vornhagen et al.   Journal for ImmunoTherapy of Cancer

Tisagenlecleucel in Adult Relapsed or Refractory Diffuse Large B-Cell Lymphoma

(2018) Stephen J. Schuster et al.   NEW ENGLAND JOURNAL OF MEDICINE

Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma

(2017) Sattva S. Neelapu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Evaluating optimal therapy robustness by virtual expansion of a sample population, with a case study in cancer immunotherapy

(2017) Syndi Barish et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumor Static Concentration Curves in Combination Therapy

(2016) Tim Cardilin et al.   AAPS Journal

Mechanistic Projection of First-in-Human Dose for Bispecific Immunomodulatory P-Cadherin LP-DART: An Integrated PK/PD Modeling Approach

(2016) X Chen et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial

(2015) Daniel W Lee et al.   LANCET

Efficacy and Toxicity Management of 19-28z CAR T Cell Therapy in B Cell Acute Lymphoblastic Leukemia

(2014) M. L. Davila et al.   Science Translational Medicine

Prevention of adverse events of interferon γ gene therapy by gene delivery of interferon γ-heparin-binding domain fusion protein in mice

(2014) Mitsuru Ando et al.   Molecular Therapy-Methods & Clinical Development

Mathematical modelling of cytokine-mediated inflammation in rheumatoid arthritis

(2012) M. Baker et al.   MATHEMATICAL MEDICINE AND BIOLOGY-A JOURNAL OF THE IMA

Into the Eye of the Cytokine Storm

(2012) J. R. Tisoncik et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Dynamics of a Cytokine Storm

(2012) Hao Hong Yiu et al.   PLoS One

Dual biological effects of the cytokines interleukin-10 and interferon-γ

(2011) Cailin Moira Wilke et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Dual functionality of interleukin-1 family cytokines: implications for anti-interleukin-1 therapy

(2009) NM Luheshi et al.   BRITISH JOURNAL OF PHARMACOLOGY