Synergistic actions of Alpelisib and Melatonin in breast cancer cell lines with PIK3CA gene mutation

In vitro anticancer effects of alpelisib against PIK3CA‑mutated canine hemangiosarcoma cell lines

(2022) Marika Maeda et al.   ONCOLOGY REPORTS

Melatonin: A mitochondrial resident with a diverse skill set

(2022) Russel J. Reiter et al.   LIFE SCIENCES

Caspase‐3, a primary target for natural and synthetic compounds for cancer therapy

(2021) Poonam Yadav et al.   Chemical Biology & Drug Design

Melatonin potentiates the cytotoxic effect of Neratinib in HER2+ breast cancer through promoting endocytosis and lysosomal degradation of HER2

(2021) Zundong Liu et al.   ONCOGENE

Melatonin inhibits triple-negative breast cancer progression through the Lnc049808-FUNDC1 pathway

(2021) Anli Yang et al.   Cell Death & Disease

Melatonin inhibits proliferation, migration, and invasion by inducing ROS-mediated apoptosis via suppression of the PI3K/Akt/mTOR signaling pathway in gallbladder cancer cells

(2021) Kunlun Chen et al.   Aging-US

The PI3K subunits, P110α and P110β are potential targets for overcoming P-gp and BCRP-mediated MDR in cancer

(2020) Lei Zhang et al.   Molecular Cancer

PIK3CA H1047R Mutation Associated with a Lower Pathological Complete Response Rate in Triple-Negative Breast Cancer Patients Treated with Anthracycline-Taxane–Based Neoadjuvant Chemotherapy

(2020) Sanxing Guo et al.   Cancer Research and Treatment

Biomarkers in Triple-Negative Breast Cancer: State-of-the-Art and Future Perspectives

(2020) Stefania Cocco et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Melatonin regulates chicken granulosa cell proliferation and apoptosis by activating the mTOR signaling pathway via its receptors

(2020) Er-ying Hao et al.   POULTRY SCIENCE

Melatonin downregulates TRPC6, impairing store-operated calcium entry in triple negative breast cancer cells.

(2020) Isaac Jardin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alpelisib plus fulvestrant for PIK3CA-mutated, hormone receptor-positive, human epidermal growth factor receptor-2–negative advanced breast cancer: final overall survival results from SOLAR-1

(2020) F. André et al.   ANNALS OF ONCOLOGY

Targeting PI3K in cancer: mechanisms and advances in clinical trials

(2019) Jing Yang et al.   Molecular Cancer

Alpelisib for PIK3CA-Mutated, Hormone Receptor–Positive Advanced Breast Cancer

(2019) Fabrice André et al.   NEW ENGLAND JOURNAL OF MEDICINE

Combination therapy with BYL719 and LEE011 is synergistic and causes a greater suppression of p-S6 in triple negative breast cancer

(2019) Yuan Yuan et al.   Scientific Reports

Efficacy of PI3K inhibitors in advanced breast cancer

(2019) B Verret et al.   ANNALS OF ONCOLOGY

Melatonin activates cell death programs for the suppression of uterine leiomyoma cell proliferation

(2019) Po‐Han Lin et al.   JOURNAL OF PINEAL RESEARCH

Melatonin restrains angiogenic factors in triple-negative breast cancer by targeting miR-152-3p: In vivo and in vitro studies

(2018) Jéssica H.M. Marques et al.   LIFE SCIENCES

Screen for MicroRNA and Drug Interactions in Breast Cancer Cell Lines Points to miR-126 as a Modulator of CDK4/6 and PIK3CA Inhibitors

(2018) Federica Baldassari et al.   Frontiers in Genetics

Melatonin: An Anti-Tumor Agent in Hormone-Dependent Cancers

(2018) Javier Menéndez-Menéndez et al.   International Journal of Endocrinology

Melatonin and IL-25 modulate apoptosis and angiogenesis mediators in metastatic (CF-41) and non-metastatic (CMT-U229) canine mammary tumour cells

(2017) G. B. Gelaleti et al.   Veterinary and Comparative Oncology

Melatonin Regulates Angiogenic Factors under Hypoxia in Breast Cancer Cell Lines

(2016) Bruna Victorasso Jardim-Perassi et al.   Anti-Cancer Agents in Medicinal Chemistry

Caspase-3 and caspase-8 expression in breast cancer: caspase-3 is associated with survival

(2016) Xuan Pu et al.   APOPTOSIS

Melatonin, an inhibitory agent in breast cancer

(2016) Elaheh Nooshinfar et al.   Breast Cancer

Melatonin decreases breast cancer metastasis by modulating Rho-associated kinase protein-1 expression

(2015) Thaiz Ferraz Borin et al.   JOURNAL OF PINEAL RESEARCH

Hypoxia-inducible factor 1 and breast cancer metastasis

(2015) Zhao-ji Liu et al.   Journal of Zhejiang University-SCIENCE B

Prognostic value of vascular endothelial growth factor and hypoxia-inducible factor 1α in canine malignant mammary tumors

(2015) MARINA GOBBE MOSCHETTA et al.   ONCOLOGY REPORTS

CDK 4/6 Inhibitors Sensitize PIK3CA Mutant Breast Cancer to PI3K Inhibitors

(2014) Sadhna R. Vora et al.   CANCER CELL

Extrapineal melatonin: sources, regulation, and potential functions

(2014) Darío Acuña-Castroviejo et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Melatonin: a well-documented antioxidant with conditional pro-oxidant actions

(2014) Hong-Mei Zhang et al.   JOURNAL OF PINEAL RESEARCH

Effect of Melatonin on Tumor Growth and Angiogenesis in Xenograft Model of Breast Cancer

(2014) Bruna Victorasso Jardim-Perassi et al.   PLoS One

Melatonin Suppresses the Expression of 45S Preribosomal RNA and Upstream Binding Factor and Enhances the Antitumor Activity of Puromycin in MDA-MB-231 Breast Cancer Cells

(2013) Ji Hoon Jung et al.   Evidence-based Complementary and Alternative Medicine

Simultaneous modulation of COX-2, p300, Akt, and Apaf-1 signaling by melatonin to inhibit proliferation and induce apoptosis in breast cancer cells

(2012) Jingshu Wang et al.   JOURNAL OF PINEAL RESEARCH

Expression of melatonin receptor MT1 in cells of human invasive ductal breast carcinoma

(2012) Karolina Jablonska et al.   JOURNAL OF PINEAL RESEARCH

Intracellular redox state as determinant for melatonin antiproliferative vs cytotoxic effects in cancer cells

(2011) Ana M. Sánchez-Sánchez et al.   FREE RADICAL RESEARCH

Molecular Mechanisms of Melatonin Anticancer Effects

(2009) Steven M. Hill et al.   INTEGRATIVE CANCER THERAPIES