The PI3K subunits, P110α and P110β are potential targets for overcoming P-gp and BCRP-mediated MDR in cancer

PES1 enhances proliferation and tumorigenesis in hepatocellular carcinoma via the PI3K/AKT pathway

(2019) Jing Wang et al.   LIFE SCIENCES

CRISPR–Cas ribonucleoprotein mediated homology-directed repair for efficient targeted genome editing in microalgae Nannochloropsis oceanica IMET1

(2019) Mihris Ibnu Saleem Naduthodi et al.   Biotechnology for Biofuels

PM2.5-induced ADRB2 hypermethylation contributed to cardiac dysfunction through cardiomyocytes apoptosis via PI3K/Akt pathway

(2019) Xiaozhe Yang et al.   ENVIRONMENT INTERNATIONAL

1,25(OH)2D3 attenuates indoxyl sulfate-induced epithelial-to-mesenchymal cell transition via inactivation of PI3K/Akt/β-catenin signaling in renal tubular epithelial cells

(2019) Li-Chien Chang et al.   NUTRITION

GATA1 gene silencing inhibits invasion, proliferation and migration of cholangiocarcinoma stem cells via disrupting the PI3K/AKT pathway

(2019) Guang Shi et al.   OncoTargets and Therapy

Oncogenic Akt-FOXO3 loop favors tumor-promoting modes and enhances oxidative damage-associated hepatocellular carcinogenesis

(2019) Miao Lu et al.   BMC CANCER

The Phenylethanol Glycoside Liposome Inhibits PDGF-Induced HSC Activation via Regulation of the FAK/PI3K/Akt Signaling Pathway

(2019) Shi-Lei Zhang et al.   MOLECULES

TAL1 mediates imatinib-induced CML cell apoptosis via the PTEN/PI3K/AKT pathway

(2019) Yifan Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Priming mobilization of hair follicle stem cells triggers permanent loss of regeneration after alkylating chemotherapy

(2019) Jin Yong Kim et al.   Nature Communications

Natural product toosendanin reverses the resistance of human breast cancer cells to adriamycin as a novel PI3K inhibitor

(2018) Wang Kai et al.   BIOCHEMICAL PHARMACOLOGY

Voruciclib, a Potent CDK4/6 Inhibitor, Antagonizes ABCB1 and ABCG2-Mediated Multi-Drug Resistance in Cancer Cells

(2018) Pranav Gupta et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Function of the c-Met receptor tyrosine kinase in carcinogenesis and associated therapeutic opportunities

(2018) Yazhuo Zhang et al.   Molecular Cancer

Targeting the PI3K pathway in cancer: are we making headway?

(2018) Filip Janku et al.   Nature Reviews Clinical Oncology

Molecular structure of human P-glycoprotein in the ATP-bound, outward-facing conformation

(2018) Youngjin Kim et al.   SCIENCE

A cardiac glycoside HTF-1 isolated from Helleborus thibetanus Franch displays potent in vitro anti-cancer activity via caspase-9, MAPK and PI3K-Akt-mTOR pathways

(2018) Long Ma et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Regulation and modulation of PTEN activity

(2018) Elahe Naderali et al.   MOLECULAR BIOLOGY REPORTS

Alectinib Resistance in ALK-rearranged Lung Cancer by Dual Salvage Signaling in a Clinically Paired Resistance Model

(2018) Takahiro Tsuji et al.   MOLECULAR CANCER RESEARCH

High doses of CRISPR/Cas9 ribonucleoprotein efficiently induce gene knockout with low mosaicism in the hydrozoan Clytia hemisphaerica through microhomology-mediated deletion

(2018) Tsuyoshi Momose et al.   Scientific Reports

BMI1 promotes cardiac fibrosis in ischemia-induced heart failure via the PTEN-PI3K/Akt-mTOR signaling pathway

(2018) Wenbo Yang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

EG-VEGF silencing inhibits cell proliferation and promotes cell apoptosis in pancreatic carcinoma via PI3K/AKT/mTOR signaling pathway

(2018) Xiaogang Yan et al.   BIOMEDICINE & PHARMACOTHERAPY

Pyruvic acid/ethyl pyruvate inhibits melanogenesis in B16F10 melanoma cells through PI3K/AKT, GSK3β, and ROS-ERK signaling pathways

(2018) Siqi Zhou et al.   GENES TO CELLS

PI3K Signaling in Neurons: A Central Node for the Control of Multiple Functions

(2018) Karina Sánchez-Alegría et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Characterization and mechanism of phosphoinositide 3-kinases (PI3Ks) members in insulin-induced changes of protein metabolism in yellow catfish Pelteobagrus fulvidraco

(2017) Mei-Qin Zhuo et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Overexpression of ATP-Binding Cassette Subfamily G Member 2 Confers Resistance to Phosphatidylinositol 3-Kinase Inhibitor PF-4989216 in Cancer Cells

(2017) Chung-Pu Wu et al.   MOLECULAR PHARMACEUTICS

The Dlk1-Gtl2 Locus Preserves LT-HSC Function by Inhibiting the PI3K-mTOR Pathway to Restrict Mitochondrial Metabolism

(2016) Pengxu Qian et al.   Cell Stem Cell

Human ATP-Binding Cassette Transporter ABCG2 Confers Resistance to CUDC-907, a Dual Inhibitor of Histone Deacetylase and Phosphatidylinositol 3-Kinase

(2016) Chung-Pu Wu et al.   MOLECULAR PHARMACEUTICS

The modulation of ABC transporter-mediated multidrug resistance in cancer: A review of the past decade

(2015) Rishil J. Kathawala et al.   DRUG RESISTANCE UPDATES

Decreased expression of nucleophosmin/B23 increases drug sensitivity of adriamycin-resistant Molt-4 leukemia cells through mdr-1 regulation and Akt/mTOR signaling

(2015) Lingyan Wang et al.   IMMUNOBIOLOGY

PI3King the Lock

(2015) David King et al.   JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY

Cancer metabolism and the Warburg effect: the role of HIF-1 and PI3K

(2015) Rupert Courtnay et al.   MOLECULAR BIOLOGY REPORTS

The PI3K/Akt Pathway Regulates Oxygen Metabolism via Pyruvate Dehydrogenase (PDH)-E1  Phosphorylation

(2015) G. J. Cerniglia et al.   MOLECULAR CANCER THERAPEUTICS

Mutational profiling of kinases in glioblastoma

(2014) Fonnet E Bleeker et al.   BMC CANCER

PTEN inhibition enhances neurite outgrowth in human embryonic stem cell-derived neuronal progenitor cells

(2014) Lindsey A. Wyatt et al.   JOURNAL OF COMPARATIVE NEUROLOGY

3-Methyladenine can depress drug efflux transporters via blocking the PI3K–AKT–mTOR pathway thus sensitizing MDR cancer to chemotherapy

(2014) Zhenyou Zou et al.   JOURNAL OF DRUG TARGETING

SGK3 Mediates INPP4B-Dependent PI3K Signaling in Breast Cancer

(2014) Jessica A. Gasser et al.   MOLECULAR CELL

Targeting Class IA PI3K Isoforms Selectively Impairs Cell Growth, Survival, and Migration in Glioblastoma

(2014) Katrin Höland et al.   PLoS One

Overstimulation can create health problems due to increases in PI3K/Akt/GSK3 insensitivity and GSK3 activity

(2014) Xunxian Liu   SpringerPlus

Enhancing Chemosensitivity in ABCB1- and ABCG2-Overexpressing Cells and Cancer Stem-like Cells by An Aurora Kinase Inhibitor CCT129202

(2012) Chao Cheng et al.   MOLECULAR PHARMACEUTICS

The PI3K, Metabolic, and Autophagy Networks: Interactive Partners in Cellular Health and Disease

(2011) Naval P. Shanware et al.   Annual Review of Pharmacology and Toxicology

p37δ is a new isoform of PI3K p110δ that increases cell proliferation and is overexpressed in tumors

(2011) S Fransson et al.   ONCOGENE

Critical Role of PI3K/Akt/GSK3β in Motoneuron Specification from Human Neural Stem Cells in Response to FGF2 and EGF

(2011) Luis Ojeda et al.   PLoS One

Critical role of PI3K signaling for NF- B-dependent survival in a subset of activated B-cell-like diffuse large B-cell lymphoma cells

(2010) B. Kloo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activity of any class IA PI3K isoform can sustain cell proliferation and survival

(2010) L. C. Foukas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Energy metabolism in adult neural stem cell fate

(2010) Victoria A. Rafalski et al.   PROGRESS IN NEUROBIOLOGY

Antitumor effect of BPR-DC-2, a novel synthetic cyclic cyanoguanidine derivative, involving the inhibition of MDR-1 expression and down-regulation of p-AKT and PARP-1 in lung cancer

(2009) Shun-Lai Li et al.   INVESTIGATIONAL NEW DRUGS

DAB2IP coordinates both PI3K-Akt and ASK1 pathways for cell survival and apoptosis

(2009) D. Xie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PI3K pathway alterations in cancer: variations on a theme

(2008) T L Yuan et al.   ONCOGENE