The chaperone protein GRP78 released from MPN cells increases the expression of lysyl oxidase in a human stromal cell line

CAR T cells redirected to cell surface GRP78 display robust anti-acute myeloid leukemia activity and do not target hematopoietic progenitor cells

(2022) Nikhil Hebbar et al.   Nature Communications

Cell surface expression of GRP78 and CXCR4 is associated with childhood high-risk acute lymphoblastic leukemia at diagnostics

(2022) Tania Angeles-Floriano et al.   Scientific Reports

Megakaryocytes Are Regulators of the Tumor Microenvironment and Malignant Hematopoietic Progenitor Cells in Myelofibrosis

(2022) Lilian Varricchio et al.   Frontiers in Oncology

ER Stress and Unfolded Protein Response in Leukemia: Friend, Foe, or Both?

(2021) Kelly Féral et al.   Biomolecules

Linking cell-surface GRP78 to cancer: From basic research to clinical value of GRP78 antibodies

(2021) Isabelle Hernandez et al.   CANCER LETTERS

Myelofibrosis biology and contemporary management

(2020) Naseema Gangat et al.   BRITISH JOURNAL OF HAEMATOLOGY

GRP78-Mediated Signaling Contributes to Axonal Growth Resulting in Motor Function Recovery in Spinal Cord-Injured Mice

(2020) Yoshitaka Tanie et al.   Frontiers in Pharmacology

Endoplasmic reticulum stress, unfolded protein response and autophagy contribute to resistance to glucocorticoid treatment in human acute lymphoblastic leukaemia cells

(2020) Sangkab Sudsaward et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Ubiquitin C-terminal hydrolase L1 (UCHL1) regulates post-myocardial infarction cardiac fibrosis through glucose-regulated protein of 78 kDa (GRP78)

(2020) Qian Lei et al.   Scientific Reports

Tumor-Secreted GRP78 Promotes the Establishment of a Pre-metastatic Niche in the Liver Microenvironment

(2020) Lu Chen et al.   Frontiers in Immunology

Cell surface expression of 78 kDa glucose regulated protein (GRP78) mediates diabetic nephropathy

(2019) Richard Van Krieken et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tumor-secreted GRP78 facilitates the migration of macrophages into tumors by promoting cytoskeleton remodeling

(2019) Xiaoqin La et al.   CELLULAR SIGNALLING

Glycolytic enzyme hexokinase II is a putative therapeutic target in B cell malignant lymphoma

(2019) Kei Nakajima et al.   EXPERIMENTAL HEMATOLOGY

Impact of hydroxycarbamide and interferon-α on red cell adhesion and membrane protein expression in polycythemia vera

(2018) Mégane Brusson et al.   HAEMATOLOGICA

Endoplasmic reticulum stress in the pathogenesis of fibrotic disease

(2018) Jonathan A. Kropski et al.   JOURNAL OF CLINICAL INVESTIGATION

Impact of hydroxycarbamide and interferon-α on red cell adhesion and membrane protein expression in polycythemia vera

(2018) Mégane Brusson et al.   HAEMATOLOGICA

BCR-ABL tyrosine kinase inhibition induces metabolic vulnerability by preventing the integrated stress response in K562 cells

(2018) Yu Kato et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Secreted GRP78 activates EGFR-SRC-STAT3 signaling and confers the resistance to sorafeinib in HCC cells

(2017) Rui Li et al.   Oncotarget

Expression and release of glucose-regulated protein-78 (GRP78) in multiple myeloma

(2017) Normann Steiner et al.   Oncotarget

Involvement of ER stress, PI3K/AKT activation, and lung fibroblast proliferation in bleomycin-induced pulmonary fibrosis

(2017) Han-Shui Hsu et al.   Scientific Reports

Activation of the thrombopoietin receptor by mutant calreticulin in CALR-mutant myeloproliferative neoplasms

(2016) M. Araki et al.   BLOOD

A GRP78-Directed Monoclonal Antibody Recaptures Response in Refractory Multiple Myeloma with Extramedullary Involvement

(2016) L. Rasche et al.   CLINICAL CANCER RESEARCH

Role of neoplastic monocyte-derived fibrocytes in primary myelofibrosis

(2016) Srdan Verstovsek et al.   JOURNAL OF EXPERIMENTAL MEDICINE

GRP78 and CHOP modulate macrophage apoptosis and the development of bleomycin-induced pulmonary fibrosis

(2016) Ehab A Ayaub et al.   JOURNAL OF PATHOLOGY

Human bone marrow stem cells cultured under hypoxic conditions present altered characteristics and enhanced in vivo tissue regeneration

(2015) Jung-Seok Lee et al.   BONE

Molecular chaperone GRP78 enhances aggresome delivery to autophagosomes to promote drug resistance in multiple myeloma

(2015) Mohamed A.Y. Abdel Malek et al.   Oncotarget

Physiological ER Stress Mediates the Differentiation of Fibroblasts

(2015) Shinsuke Matsuzaki et al.   PLoS One

A Novel Function for Lysyl Oxidase in Pluripotent Mesenchymal Cell Proliferation and Relevance to Inflammation-Associated Osteopenia

(2014) Roozbeh Khosravi et al.   PLoS One

The expression of lysyl-oxidase gene family members in myeloproliferative neoplasms

(2013) T. Tadmor et al.   AMERICAN JOURNAL OF HEMATOLOGY

Crucial Role for Endoplasmic Reticulum Stress During Megakaryocyte Maturation

(2013) Jose J. Lopez et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

GRP78 secreted by tumor cells stimulates differentiation of bone marrow mesenchymal stem cells to cancer-associated fibroblasts

(2013) Yanan Peng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Anti-citrullinated Protein Antibodies Activated ERK1/2 and JNK Mitogen-activated Protein Kinases via Binding to Surface-expressed Citrullinated GRP78 on Mononuclear Cells

(2012) Ming-Chi Lu et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Knockdown of glucose-regulated protein 78 decreases the invasion, metalloproteinase expression and ECM degradation in hepatocellular carcinoma cells

(2012) Hongdan Li et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Control of Megakaryocyte Expansion and Bone Marrow Fibrosis by Lysyl Oxidase

(2011) Alexia Eliades et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GRP-78 secreted by tumor cells blocks the antiangiogenic activity of bortezomib

(2009) J. Kern et al.   BLOOD