Linking cell-surface GRP78 to cancer: From basic research to clinical value of GRP78 antibodies
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Title
Linking cell-surface GRP78 to cancer: From basic research to clinical value of GRP78 antibodies
Authors
Keywords
Cell-surface GRP78, GRP78 antibodies, Tumor development, Prognosis, Therapy
Journal
CANCER LETTERS
Volume 524, Issue -, Pages 1-14
Publisher
Elsevier BV
Online
2021-10-12
DOI
10.1016/j.canlet.2021.10.004
References
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Note: Only part of the references are listed.- Nanobodies as efficient drug-carriers: Progress and trends in chemotherapy
- (2021) Sandeep Surendra Panikar et al. JOURNAL OF CONTROLLED RELEASE
- Cell surface GRP78 promotes stemness in normal and neoplastic cells
- (2020) Clay Conner et al. Scientific Reports
- Impairment of Membrane Lipid Homeostasis by Bichalcone Analog TSWU-BR4 Attenuates Function of GRP78 in Regulation of the Oxidative Balance and Invasion of Cancer Cells
- (2020) Tsung-Lin Lee et al. Cells
- COVID-19 spike-host cell receptor GRP78 binding site prediction
- (2020) Ibrahim M. Ibrahim et al. JOURNAL OF INFECTION
- Activated α2-macroglobulin binding to cell surface GRP78 induces trophoblastic cell fusion
- (2020) Daniel Bastida-Ruiz et al. Scientific Reports
- Cell surface GRP78 signaling: An emerging role as a transcriptional modulator in cancer
- (2020) Udhayakumar Gopal et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Tumor-Secreted GRP78 Promotes the Establishment of a Pre-metastatic Niche in the Liver Microenvironment
- (2020) Lu Chen et al. Frontiers in Immunology
- Cell surface expression of 78 kDa glucose regulated protein (GRP78) mediates diabetic nephropathy
- (2019) Richard Van Krieken et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Targeting cell surface-associated GRP78 enhances pancreatic cancer radiosensitivity by reducing YAP/TAZ protein signaling
- (2019) Udhayakumar Gopal et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- GRP 78 antibodies are associated with clinical phenotype in neuromyelitis optica
- (2019) Fumitaka Shimizu et al. Annals of Clinical and Translational Neurology
- Endoplasmic Reticulum Stress Pathway, the Unfolded Protein Response, Modulates Immune Function in the Tumor Microenvironment to Impact Tumor Progression and Therapeutic Response
- (2019) Manuel U. Ramirez et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Middle East respiratory syndrome coronavirus and bat coronavirus HKU9 both can utilize GRP78 for attachment onto host cells
- (2018) Hin Chu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- CLPTM1L/CRR9 ectodomain interaction with GRP78 at the cell surface signals for survival and chemoresistance upon ER stress in pancreatic adenocarcinoma cells
- (2018) William R. Clarke et al. INTERNATIONAL JOURNAL OF CANCER
- IL-34 cell surface localization regulated by the 78 kDa glucose-regulated protein facilitates the differentiation of monocytic cells
- (2018) Sayaka Ogawa et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- GRP78 Is an Important Host Factor for Japanese Encephalitis Virus Entry and Replication in Mammalian Cells
- (2017) Minu Nain et al. JOURNAL OF VIROLOGY
- CRIPTO and its signaling partner GRP78 drive the metastatic phenotype in human osteotropic prostate cancer
- (2017) E Zoni et al. ONCOGENE
- Plasminogen kringle 5 suppresses gastric cancer via regulating HIF-1α and GRP78
- (2017) Shuhuan Fang et al. Cell Death & Disease
- Unfolded protein response signaling impacts macrophage polarity to modulate breast cancer cell clearance and melanoma immune checkpoint therapy responsiveness
- (2017) David R. Soto-Pantoja et al. Oncotarget
- Autoantibodies against glucose-regulated protein 78 as serological biomarkers in metastatic and recurrent hepatocellular carcinoma
- (2017) Xia Ying et al. Oncotarget
- Circulating GRP78 antibodies from ovarian cancer patients: a promising tool for cancer cell targeting drug delivery system?
- (2017) Kylie Van Hoesen et al. Oncotarget
- Cell surface GRP78 promotes tumor cell histone acetylation through metabolic reprogramming: a mechanism which modulates the Warburg effect
- (2017) Udhayakumar Gopal et al. Oncotarget
- Endoplasmic Reticulum Stress Protein GRP78 Modulates Lipid Metabolism to Control Drug Sensitivity and Antitumor Immunity in Breast Cancer
- (2016) Katherine L. Cook et al. CANCER RESEARCH
- Antibody Targeting GRP78 Enhances the Efficacy of Radiation Therapy in Human Glioblastoma and Non–Small Cell Lung Cancer Cell Lines and Tumor Models
- (2016) David Y.A. Dadey et al. CLINICAL CANCER RESEARCH
- A GRP78-Directed Monoclonal Antibody Recaptures Response in Refractory Multiple Myeloma with Extramedullary Involvement
- (2016) L. Rasche et al. CLINICAL CANCER RESEARCH
- Glucose-Regulated Protein 78-Induced Myeloid Antigen-Presenting Cells Maintained Tolerogenic Signature upon LPS Stimulation
- (2016) Muyang Yang et al. Frontiers in Immunology
- The role of c-Src in the invasion and metastasis of hepatocellular carcinoma cells induced by association of cell surface GRP78 with activated α2M
- (2015) Song Zhao et al. BMC CANCER
- GRP78 is implicated in the modulation of tumor aerobic glycolysis by promoting autophagic degradation of IKKβ
- (2015) Zongwei Li et al. CELLULAR SIGNALLING
- GRP78-directed immunotherapy in relapsed or refractory multiple myeloma - results from a phase 1 trial with the monoclonal immunoglobulin M antibody PAT-SM6
- (2015) L. Rasche et al. HAEMATOLOGICA
- Characterization and Mechanism of Stress-induced Translocation of 78-Kilodalton Glucose-regulated Protein (GRP78) to the Cell Surface
- (2015) Yuan-Li Tsai et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cell surface GRP78: A potential marker of good prognosis and response to chemotherapy in breast cancer
- (2015) RINAT YERUSHALMI et al. Oncology Letters
- Role of PAR-4 in ovarian cancer
- (2015) Sonia Meynier et al. Oncotarget
- GRP78-directed immunotherapy in relapsed or refractory multiple myeloma - results from a phase 1 trial with the monoclonal immunoglobulin M antibody PAT-SM6
- (2015) L. Rasche et al. HAEMATOLOGICA
- Pharmacological induction of cell surface GRP78 contributes to apoptosis in triple negative breast cancer cells
- (2015) Annat Raiter et al. Oncotarget
- GRP78 Secreted by Colon Cancer Cells Facilitates Cell Proliferation via PI3K/Akt Signaling
- (2014) Rong Fu et al. Asian Pacific Journal of Cancer Prevention
- Isthmin targets cell-surface GRP78 and triggers apoptosis via induction of mitochondrial dysfunction
- (2014) M Chen et al. CELL DEATH AND DIFFERENTIATION
- GRP78 clustering at the cell surface of neurons transduces the action of exogenous alpha-synuclein
- (2014) S Bellani et al. CELL DEATH AND DIFFERENTIATION
- Binding of Tissue-type Plasminogen Activator to the Glucose-regulated Protein 78 (GRP78) Modulates Plasminogen Activation and Promotes Human Neuroblastoma Cell Proliferationin Vitro
- (2014) Mario Gonzalez-Gronow et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- CRIPTO/GRP78 Signaling Maintains Fetal and Adult Mammary Stem Cells Ex Vivo
- (2014) Benjamin T. Spike et al. Stem Cell Reports
- ER stress-induced cell death mechanisms
- (2013) Renata Sano et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Monoclonal Antibody against Cell Surface GRP78 as a Novel Agent in Suppressing PI3K/AKT Signaling, Tumor Growth, and Metastasis
- (2013) R. Liu et al. CLINICAL CANCER RESEARCH
- Cell-surface GRP78 facilitates colorectal cancer cell migration and invasion
- (2013) Zongwei Li et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Early development of PAT-SM6 for the treatment of melanoma
- (2013) Frank Hensel et al. MELANOMA RESEARCH
- The Natural Human IgM Antibody PAT-SM6 Induces Apoptosis in Primary Human Multiple Myeloma Cells by Targeting Heat Shock Protein GRP78
- (2013) Leo Rasche et al. PLoS One
- Role of Prostate Apoptosis Response 4 in Translocation of GRP78 from the Endoplasmic Reticulum to the Cell Surface of Trophoblastic Cells
- (2013) Marie Cohen et al. PLoS One
- Anti-KDEL-coated nanoparticles: A promising tumor targeting approach for ovarian cancer?
- (2012) Florence Delie et al. BIOCHIMIE
- A murine monoclonal antibody directed against the carboxyl-terminal domain of GRP78 suppresses melanoma growth in mice
- (2012) Gustaaf G. de Ridder et al. MELANOMA RESEARCH
- Quantum Dot- Conjugated Anti-GRP78 scFv Inhibits Cancer Growth in Mice
- (2012) Weiming Xu et al. MOLECULES
- RNA Interference Mediated Inhibition of Dengue Virus Multiplication and Entry in HepG2 Cells
- (2012) Mohammed Abdelfatah Alhoot et al. PLoS One
- Involvement of Membrane GRP78 in Trophoblastic Cell Fusion
- (2012) Sarah Fradet et al. PLoS One
- Receptor-Recognized α2-Macroglobulin Binds to Cell Surface-Associated GRP78 and Activates mTORC1 and mTORC2 Signaling in Prostate Cancer Cells
- (2012) Uma K. Misra et al. PLoS One
- GRP78-targeted nanotherapy against castrate-resistant prostate cancer cells expressing membrane GRP78
- (2012) Florence Delie et al. Targeted Oncology
- Beyond the endoplasmic reticulum: atypical GRP78 in cell viability, signalling and therapeutic targeting
- (2011) Min Ni et al. BIOCHEMICAL JOURNAL
- The Par-4-GRP78 TRAIL, more twists and turns
- (2011) Amy S. Lee CANCER BIOLOGY & THERAPY
- Purified autoantibodies against glucose-regulated protein 78 (GRP78) promote apoptosis and decrease invasiveness of ovarian cancer cells
- (2011) Marie Cohen et al. CANCER LETTERS
- Cripto Regulates Hematopoietic Stem Cells as a Hypoxic-Niche-Related Factor through Cell Surface Receptor GRP78
- (2011) Kenichi Miharada et al. Cell Stem Cell
- Inhibition of NF-κB1 and NF-κB2 activation in prostate cancer cells treated with antibody against the carboxyl terminal domain of GRP78: Effect of p53 upregulation
- (2010) U.K. Misra et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Ligation of cell surface GRP78 with antibody directed against the COOH-terminal domain of GRP78 suppresses Ras/MAPK and PI 3-kinase/AKT signaling while promoting caspase activation in human prostate cancer cells
- (2010) Uma K. Misra et al. CANCER BIOLOGY & THERAPY
- Binding of Anti-GRP78 Autoantibodies to Cell Surface GRP78 Increases Tissue Factor Procoagulant Activity via the Release of Calcium from Endoplasmic Reticulum Stores
- (2010) Ali A. Al-Hashimi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cell Surface Relocalization of the Endoplasmic Reticulum Chaperone and Unfolded Protein Response Regulator GRP78/BiP
- (2010) Yi Zhang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Induction of the unfolded protein response by α-synuclein in experimental models of Parkinson’s disease
- (2010) Arianna Bellucci et al. JOURNAL OF NEUROCHEMISTRY
- Elimination of head and neck cancer initiating cells through targeting glucose regulated protein78 signaling
- (2010) Meng-Ju Wu et al. Molecular Cancer
- Crystal Structures of the ATPase Domains of Four Human Hsp70 Isoforms: HSPA1L/Hsp70-hom, HSPA2/Hsp70-2, HSPA6/Hsp70B', and HSPA5/BiP/GRP78
- (2010) Magdalena Wisniewska et al. PLoS One
- Modulation of the unfolded protein response in prostate cancer cells by antibody-directed against the carboxyl-terminal domain of GRP78
- (2009) U. K. Misra et al. APOPTOSIS
- Plasminogen Kringle 5 Induces Apoptosis of Brain Microvessel Endothelial Cells: Sensitization by Radiation and Requirement for GRP78 and LRP1
- (2009) Braden C. McFarland et al. CANCER RESEARCH
- The Tumor Suppressor Par-4 Activates an Extrinsic Pathway for Apoptosis
- (2009) Ravshan Burikhanov et al. CELL
- Patient-derived tumor-reactive antibodies as diagnostic markers for ovarian cancer
- (2009) Douglas D. Taylor et al. GYNECOLOGIC ONCOLOGY
- Molecular Chaperone BiP Interacts with Borna Disease Virus Glycoprotein at the Cell Surface
- (2009) T. Honda et al. JOURNAL OF VIROLOGY
- Ligation of cancer cell surface GRP78 with antibodies directed against its COOH-terminal domain up-regulates p53 activity and promotes apoptosis
- (2009) U. K. Misra et al. MOLECULAR CANCER THERAPEUTICS
- GRP78 as a marker of pre-eclampsia: an exploratory study
- (2009) A. Laverriere et al. MOLECULAR HUMAN REPRODUCTION
- Blockade of Cripto binding to cell surface GRP78 inhibits oncogenic Cripto signaling via MAPK/PI3K and Smad2/3 pathways
- (2009) J A Kelber et al. ONCOGENE
- A new tumor-specific variant of GRP78 as target for antibody-based therapy
- (2008) Nicole Rauschert et al. LABORATORY INVESTIGATION
- Identification of Proteins Associating with Glycosylphosphatidylinositol- Anchored T-Cadherin on the Surface of Vascular Endothelial Cells: Role for Grp78/BiP in T-Cadherin-Dependent Cell Survival
- (2008) M. Philippova et al. MOLECULAR AND CELLULAR BIOLOGY
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