Megakaryocytes Are Regulators of the Tumor Microenvironment and Malignant Hematopoietic Progenitor Cells in Myelofibrosis

How I Diagnose Primary Myelofibrosis

(2022) Sonam Prakash et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

Single-Cell Analysis of Ploidy and Transcriptome Reveals Functional and Spatial Divergency in Murine Megakaryopoiesis

(2021) Shu Sun et al.   BLOOD

TGF-β1 protein trap AVID200 beneficially affects hematopoiesis and bone marrow fibrosis in myelofibrosis

(2021) Lilian Varricchio et al.   JCI Insight

Treatment of Myelofibrosis Patients with the TGF-β 1/3 Inhibitor AVID200 (MPN-RC 118) Induces a Profound Effect on Platelet Production

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PD-1 inhibition in advanced myeloproliferative neoplasms

(2021) Gabriela Hobbs et al.   Blood Advances

Dual targeting of TGF-β and PD-L1 via a bifunctional anti-PD-L1/TGF-βRII agent: status of preclinical and clinical advances

(2020) Hanne Lind et al.   Journal for ImmunoTherapy of Cancer

Single-Cell Analyses Reveal Megakaryocyte-Biased Hematopoiesis in Myelofibrosis and Identify Mutant Clone-Specific Targets

(2020) Bethan Psaila et al.   MOLECULAR CELL

Selective inhibition of TGFβ1 activation overcomes primary resistance to checkpoint blockade therapy by altering tumor immune landscape

(2020) Constance J. Martin et al.   Science Translational Medicine

Primary myelofibrosis: 2021 update on diagnosis, risk‐stratification and management

(2020) Ayalew Tefferi   AMERICAN JOURNAL OF HEMATOLOGY

Heterogeneous bone-marrow stromal progenitors drive myelofibrosis via a druggable alarmin axis

(2020) Nils B. Leimkühler et al.   Cell Stem Cell

Molecular Interactions of Antibody Drugs Targeting PD-1, PD-L1, and CTLA-4 in Immuno-Oncology

(2019) Hyun Lee et al.   MOLECULES

Cytokine production in myelofibrosis exhibits differential responsiveness to JAK-STAT, MAP kinase, and NFκB signaling

(2019) Daniel A. C. Fisher et al.   LEUKEMIA

The central role of inflammatory signaling in the pathogenesis of myelodysplastic syndromes

(2019) David A. Sallman et al.   BLOOD

New Insights Into the Differentiation of Megakaryocytes From Hematopoietic Progenitors

(2019) Leila J. Noetzli et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Combined Inhibition of TGF-β Signaling and the PD-L1 Immune Checkpoint Is Differentially Effective in Tumor Models

(2019) Heng Sheng Sow et al.   Cells

Dual TGF-β and PD-1 blockade synergistically enhances MAGE-A3-specific CD8+ T cell response in esophageal squamous cell carcinoma

(2018) Xinfeng Chen et al.   INTERNATIONAL JOURNAL OF CANCER

TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis

(2018) Daniele V. F. Tauriello et al.   NATURE

Oncogenic JAK2 V617F causes PD-L1 expression, mediating immune escape in myeloproliferative neoplasms

(2018) Alessandro Prestipino et al.   Science Translational Medicine

Enhanced preclinical antitumor activity of M7824, a bifunctional fusion protein simultaneously targeting PD-L1 and TGF-β

(2018) Yan Lan et al.   Science Translational Medicine

Co-transfer of tumor-specific effector and memory CD8+ T cells enhances the efficacy of adoptive melanoma immunotherapy in a mouse model

(2018) Amanda Contreras et al.   Journal for ImmunoTherapy of Cancer

TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells

(2018) Sanjeev Mariathasan et al.   NATURE

TGFβ Blockade Augments PD-1 Inhibition to Promote T-Cell Mediated Regression of Pancreatic Cancer

(2018) Daniel R Principe et al.   MOLECULAR CANCER THERAPEUTICS

Inflammation and myeloproliferative neoplasms

(2017) Federico Lussana et al.   JOURNAL OF AUTOIMMUNITY

Downregulation of GATA1 drives impaired hematopoiesis in primary myelofibrosis

(2017) Laure Gilles et al.   JOURNAL OF CLINICAL INVESTIGATION

The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors

(2017) Emma Lefrançais et al.   NATURE

Blockade of surface-bound TGF-β on regulatory T cells abrogates suppression of effector T cell function in the tumor microenvironment

(2017) Sadna Budhu et al.   Science Signaling

Blockade of surface-bound TGF-β on regulatory T cells abrogates suppression of effector T cell function in the tumor microenvironment

(2017) Sadna Budhu et al.   Science Signaling

Mesenchymal Inflammation Drives Genotoxic Stress in Hematopoietic Stem Cells and Predicts Disease Evolution in Human Pre-leukemia

(2016) Noemi A. Zambetti et al.   Cell Stem Cell

Role of neoplastic monocyte-derived fibrocytes in primary myelofibrosis

(2016) Srdan Verstovsek et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Myeloproliferative neoplasms and inflammation: whether to target the malignant clone or the inflammatory process or both

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Lipocalin produced by myelofibrosis cells affects the fate of both hematopoietic and marrow microenvironmental cells

(2015) M. Lu et al.   BLOOD

Calreticulin mutants in mice induce an MPL-dependent thrombocytosis with frequent progression to myelofibrosis

(2015) C. Marty et al.   BLOOD

Inflammation-Induced Emergency Megakaryopoiesis Driven by Hematopoietic Stem Cell-like Megakaryocyte Progenitors

(2015) Simon Haas et al.   Cell Stem Cell

Protein kinase Cɛ inhibition restores megakaryocytic differentiation of hematopoietic progenitors from primary myelofibrosis patients

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Inflammation as a Keystone of Bone Marrow Stroma Alterations in Primary Myelofibrosis

(2015) Christophe Desterke et al.   MEDIATORS OF INFLAMMATION

Impact of Inflammation on Myeloproliferative Neoplasm Symptom Development

(2015) Holly L. Geyer et al.   MEDIATORS OF INFLAMMATION

JAK-STAT Pathway Activation in Malignant and Nonmalignant Cells Contributes to MPN Pathogenesis and Therapeutic Response

(2015) M. Kleppe et al.   Cancer Discovery

Long-term survival and blast transformation in molecularly annotated essential thrombocythemia, polycythemia vera, and myelofibrosis

(2014) A. Tefferi et al.   BLOOD

NF-κB Directs Dynamic Super Enhancer Formation in Inflammation and Atherogenesis

(2014) Jonathan D. Brown et al.   MOLECULAR CELL

Megakaryocytes maintain homeostatic quiescence and promote post-injury regeneration of hematopoietic stem cells

(2014) Meng Zhao et al.   NATURE MEDICINE

Megakaryocytes regulate hematopoietic stem cell quiescence through CXCL4 secretion

(2014) Ingmar Bruns et al.   NATURE MEDICINE

Characterization of the TGF- 1 signaling abnormalities in the Gata1low mouse model of myelofibrosis

(2013) M. Zingariello et al.   BLOOD

Myeloproliferative Neoplasia Remodels the Endosteal Bone Marrow Niche into a Self-Reinforcing Leukemic Niche

(2013) Koen Schepers et al.   Cell Stem Cell

TGFβ restores hematopoietic homeostasis after myelosuppressive chemotherapy

(2013) Fabienne Brenet et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Megakaryocytes co-localise with hemopoietic stem cells and release cytokines that up-regulate stem cell proliferation

(2013) Shen Y. Heazlewood et al.   Stem Cell Research

Chronic inflammation as a promotor of mutagenesis in essential thrombocythemia, polycythemia vera and myelofibrosis. A human inflammation model for cancer development?

(2012) Hans Carl Hasselbalch   LEUKEMIA RESEARCH

TNF  facilitates clonal expansion of JAK2V617F positive cells in myeloproliferative neoplasms

(2011) A. G. Fleischman et al.   BLOOD

In Vitro Megakaryocyte Differentiation and Proplatelet Formation in Ph-Negative Classical Myeloproliferative Neoplasms: Distinct Patterns in the Different Clinical Phenotypes

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TGF-β: the sword, the wand, and the shield of FOXP3+ regulatory T cells

(2011) Dat Q. Tran   Journal of Molecular Cell Biology

Conditional expression of heterozygous or homozygous Jak2V617F from its endogenous promoter induces a polycythemia vera-like disease

(2010) H. Akada et al.   BLOOD