MEIS inhibitors reduce the viability of primary leukemia cells and Stem cells by inducing apoptosis

Competitive inhibition of IL-2/IL-2R has a dual effect on HSC ex vivo expansion and IL-2R (CD25) content

(2022) Merve Uslu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

BML‐260 promotes the growth of cord blood and mobilized peripheral blood hematopoietic stem and progenitor cells with improved reconstitution ability

(2022) Esra Albayrak et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Small molecule‐mediated modulation of ubiquitination and neddylation improves HSC function ex vivo

(2021) Esra Albayrak et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Development of Small Molecule MEIS Inhibitors that modulate HSC activity

(2020) Raife Dilek Turan et al.   Scientific Reports

FLT3 mutations in acute myeloid leukemia: Therapeutic paradigm beyond inhibitor development

(2019) Hitoshi Kiyoi et al.   CANCER SCIENCE

c-Myc inhibitor 10074-G5 induces murine and human hematopoietic stem and progenitor cell expansion and HDR modulator Rad51 expression

(2018) Merve Aksoz et al.   CURRENT CANCER DRUG TARGETS

Leukemic stem cells: identification and clinical application

(2017) Diana Hanekamp et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Analysis of possible genetic risk factors contributing to development of childhood acute lymphoblastic leukaemia in the Latvian population

(2016) Madara Kreile et al.   Archives of Medical Science

Effect of hypoxia-inducible factors in normal and leukemic stem cell regulation and their potential therapeutic impact

(2016) Kevin Rouault-Pierre et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Hypoxia and Hypoxia-Inducible Factors in Leukemias

(2016) Margaux Deynoux et al.   Frontiers in Oncology

The Cancer Genome Atlas Pan-Cancer analysis project

(2013) John N Weinstein et al.   NATURE GENETICS

Meis1 regulates the metabolic phenotype and oxidant defense of hematopoietic stem cells

(2012) F. Kocabas et al.   BLOOD

Targeting HIF1α Eliminates Cancer Stem Cells in Hematological Malignancies

(2011) Yin Wang et al.   Cell Stem Cell

Leukemia stem cells

(2011) Eike C. Buss et al.   INTERNATIONAL JOURNAL OF CANCER

MEIS1, PREP1, and PBX4 Are Differentially Expressed in Acute Lymphoblastic Leukemia: Association of MEIS1 Expression with Higher Proliferation and Chemotherapy Resistance

(2011) Judith A Rosales-Aviña et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

The Distinct Metabolic Profile of Hematopoietic Stem Cells Reflects Their Location in a Hypoxic Niche

(2010) Tugba Simsek et al.   Cell Stem Cell

Monoclonal Antibody-Mediated Targeting of CD123, IL-3 Receptor α Chain, Eliminates Human Acute Myeloid Leukemic Stem Cells

(2009) Liqing Jin et al.   Cell Stem Cell

A role for MEIS1 in MLL-fusion gene leukemia

(2008) A. R. Kumar et al.   BLOOD