Structure determination and analysis of titin A-band fibronectin type III domains provides insights for disease-linked variants and protein oligomerisation

Immunological and Structural Characterization of Titin Main Immunogenic Region; I110 Domain Is the Target of Titin Antibodies in Myasthenia Gravis

(2023) Christos Stergiou et al.   Biomedicines

Molecular insights into titin’s A-band

(2023) Jennifer R. Fleming et al.   JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY

ColabFold: making protein folding accessible to all

(2022) Milot Mirdita et al.   NATURE METHODS

US-align: universal structure alignments of proteins, nucleic acids, and macromolecular complexes

(2022) Chengxin Zhang et al.   NATURE METHODS

Making sense of missense variants in TTN-related congenital myopathies

(2021) Martin Rees et al.   ACTA NEUROPATHOLOGICA

Titin kinase ubiquitination aligns autophagy receptors with mechanical signals in the sarcomere

(2021) Julius Bogomolovas et al.   EMBO REPORTS

Highly accurate protein structure prediction with AlphaFold

(2021) John Jumper et al.   NATURE

The Axial Alignment of Titin on the Muscle Thick Filament Supports Its Role as a Molecular Ruler

(2020) Pauline Bennett et al.   JOURNAL OF MOLECULAR BIOLOGY

Modifications of Titin Contribute to the Progression of Cardiomyopathy and Represent a Therapeutic Target for Treatment of Heart Failure

(2020) Charles Tharp et al.   Journal of Clinical Medicine

2StrucCompare: a webserver for visualizing small but noteworthy differences between protein tertiary structures through interrogation of the secondary structure content

(2019) Elliot D Drew et al.   NUCLEIC ACIDS RESEARCH

Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix

(2019) Dorothee Liebschner et al.   Acta Crystallographica Section D-Structural Biology

Congenital titinopathy: Comprehensive characterisation and pathogenic insights

(2018) Emily C. Oates et al.   ANNALS OF NEUROLOGY

SWISS-MODEL: homology modelling of protein structures and complexes

(2018) Andrew Waterhouse et al.   NUCLEIC ACIDS RESEARCH

CADD: predicting the deleteriousness of variants throughout the human genome

(2018) Philipp Rentzsch et al.   NUCLEIC ACIDS RESEARCH

Integrating macromolecular X-ray diffraction data with the graphical user interface iMosflm

(2017) Harold R Powell et al.   Nature Protocols

The sarcomeric cytoskeleton: from molecules to motion

(2016) Mathias Gautel et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Titin-truncating variants affect heart function in disease cohorts and the general population

(2016) Sebastian Schafer et al.   NATURE GENETICS

Exploration of pathomechanisms triggered by a single-nucleotide polymorphism in titin's I-band: the cardiomyopathy-linked mutation T2580I

(2016) Julius Bogomolovas et al.   Open Biology

Biophysical characterization of naturally occurring titin M10 mutations

(2015) Michael W. Rudloff et al.   PROTEIN SCIENCE

Solution NMR assignment of the heavy chain complex of the human cardiac myosin regulatory light chain

(2014) Elena Rostkova et al.   Biomolecular NMR Assignments

Gigantic Business

(2014) Wolfgang A. Linke et al.   CIRCULATION RESEARCH

Hereditary myopathy with early respiratory failure is associated with misfolding of the titin fibronectin III 119 subdomain

(2014) Carola Hedberg et al.   NEUROMUSCULAR DISORDERS

Structure–Critical Distribution of Aromatic Residues in the Fibronectin Type III Protein Family

(2014) Ema Hoxha et al.   PROTEIN JOURNAL

Titin kinase is an inactive pseudokinase scaffold that supports MuRF1 recruitment to the sarcomeric M-line

(2014) J. Bogomolovas et al.   Open Biology

mCSM: predicting the effects of mutations in proteins using graph-based signatures

(2013) Douglas E. V. Pires et al.   BIOINFORMATICS

Recessive TTN truncating mutations define novel forms of core myopathy with heart disease

(2013) C. Chauveau et al.   HUMAN MOLECULAR GENETICS

Genetic complexity in hypertrophic cardiomyopathy revealed by high-throughput sequencing

(2013) Luis R Lopes et al.   JOURNAL OF MEDICAL GENETICS

Titin mutation segregates with hereditary myopathy with early respiratory failure

(2012) Gerald Pfeffer et al.   BRAIN

Truncations of Titin Causing Dilated Cardiomyopathy

(2012) Daniel S. Herman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Atomic model of the human cardiac muscle myosin filament

(2012) H. A. AL-Khayat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The Giant Protein Titin: A Regulatory Node That Integrates Myocyte Signaling Pathways

(2011) Martina Krüger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

(2011) F. Sievers et al.   Molecular Systems Biology

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The Structure of the FnIII Tandem A77-A78 Points to a Periodically Conserved Architecture in the Myosin-Binding Region of Titin

(2010) Rainer M. Bucher et al.   JOURNAL OF MOLECULAR BIOLOGY

Cardiac Ankyrin Repeat Protein Gene (ANKRD1) Mutations in Hypertrophic Cardiomyopathy

(2009) Takuro Arimura et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Interactions with titin and myomesin target obscurin and obscurin-like 1 to the M-band - implications for hereditary myopathies

(2008) A. Fukuzawa et al.   JOURNAL OF CELL SCIENCE