Exploration of pathomechanisms triggered by a single-nucleotide polymorphism in titin's I-band: the cardiomyopathy-linked mutation T2580I

Structural advances on titin: towards an atomic understanding of multi-domain functions in myofilament mechanics and scaffolding

(2015) T. Zacharchenko et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy

(2015) J. T. Hinson et al.   SCIENCE

Integrated allelic, transcriptional, and phenomic dissection of the cardiac effects of titin truncations in health and disease

(2015) Angharad M. Roberts et al.   Science Translational Medicine

A Rising Titan:TTNReview and Mutation Update

(2014) Claire Chauveau et al.   HUMAN MUTATION

Human myocytes are protected from titin aggregation-induced stiffening by small heat shock proteins

(2014) Sebastian Kötter et al.   JOURNAL OF CELL BIOLOGY

Deleting titin’s I-band/A-band junction reveals critical roles for titin in biomechanical sensing and cardiac function

(2014) Henk L. Granzier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural and sequence features of two residue turns in beta-hairpins

(2014) Bharat Madan et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Titin Mutation in Familial Restrictive Cardiomyopathy

(2013) Yael Peled et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Single Molecule Force Spectroscopy on Titin Implicates Immunoglobulin Domain Stability as a Cardiac Disease Mechanism

(2013) Brian R. Anderson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Burden of Rare Sarcomere Gene Variants in the Framingham and Jackson Heart Study Cohorts

(2012) Alexander G. Bick et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Evaluating Pathogenicity of Rare Variants From Dilated Cardiomyopathy in the Exome Era

(2012) Nadine Norton et al.   Circulation-Cardiovascular Genetics

Truncations of Titin Causing Dilated Cardiomyopathy

(2012) Daniel S. Herman et al.   NEW ENGLAND JOURNAL OF MEDICINE

The intracellular Ig fold: a robust protein scaffold for the engineering of molecular recognition

(2012) M. Bruning et al.   PROTEIN ENGINEERING DESIGN & SELECTION

An Abundance of Rare Functional Variants in 202 Drug Target Genes Sequenced in 14,002 People

(2012) M. R. Nelson et al.   SCIENCE

Recent Explosive Human Population Growth Has Resulted in an Excess of Rare Genetic Variants

(2012) A. Keinan et al.   SCIENCE

Mouse Models in Arrhythmogenic Right Ventricular Cardiomyopathy

(2012) Elisabeth M. Lodder et al.   Frontiers in Physiology

A graphical interface for the FoldX forcefield

(2011) J. Van Durme et al.   BIOINFORMATICS

Genetic Variation in Titin in Arrhythmogenic Right Ventricular Cardiomyopathy–Overlap Syndromes

(2011) Matthew Taylor et al.   CIRCULATION

MSDmotif: exploring protein sites and motifs

(2008) Adel Golovin et al.   BMC BIOINFORMATICS

A regular pattern of Ig super-motifs defines segmental flexibility as the elastic mechanism of the titin chain

(2008) E. von Castelmur et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA