Positive Selection on a Regulatory Insertion–Deletion Polymorphism inFADS2Influences Apparent Endogenous Synthesis of Arachidonic Acid

Palmitic acid (16:0) competes with omega-6 linoleic and omega-3 ɑ-linolenic acids for FADS2 mediated Δ6-desaturation

(2016) Hui Gyu Park et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The fatty acid desaturase 2 (FADS2) gene product catalyzes Δ4 desaturation to yield n-3 docosahexaenoic acid and n-6 docosapentaenoic acid in human cells

(2015) Hui Gyu Park et al.   FASEB JOURNAL

A global reference for human genetic variation

(2015) Richard A. Gibbs et al.   NATURE

Greenlandic Inuit show genetic signatures of diet and climate adaptation

(2015) M. Fumagalli et al.   SCIENCE

Vindel: a simple pipeline for checking indel redundancy

(2014) Zhiyi Li et al.   BMC BIOINFORMATICS

Imbalance of folic acid and vitamin B12 is associated with birth outcome: an Indian pregnant women study

(2014) M Gadgil et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

A genome-wide survey of CD4+ lymphocyte regulatory genetic variants identifies novel asthma genes

(2014) Sunita Sharma et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Relationship between a Common Variant in the Fatty Acid Desaturase (FADS) Cluster and Eicosanoid Generation in Humans

(2014) Austin G. Hester et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

On Detecting Incomplete Soft or Hard Selective Sweeps Using Haplotype Structure

(2014) Anna Ferrer-Admetlla et al.   MOLECULAR BIOLOGY AND EVOLUTION

selscan: An Efficient Multithreaded Program to Perform EHH-Based Scans for Positive Selection

(2014) Z. A. Szpiech et al.   MOLECULAR BIOLOGY AND EVOLUTION

Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk

(2014) Ben Zhang et al.   NATURE GENETICS

A low omega-6 polyunsaturated fatty acid (n-6 PUFA) diet increases omega-3 (n-3) long chain PUFA status in plasma phospholipids in humans

(2014) K.E. Wood et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Placental heme receptor LRP1 correlates with the heme exporter FLVCR1 and neonatal iron status

(2014) Chang Cao et al.   REPRODUCTION

DHA supplementation and pregnancy outcomes

(2013) Susan E Carlson et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

A prospective study of the effects of breastfeeding and FADS2 polymorphisms on cognition and hyperactivity/attention problems

(2013) Maria M. Groen-Blokhuis et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Genetic associations with expression for genes implicated in GWAS studies for atherosclerotic cardiovascular disease and blood phenotypes

(2013) Xiaoling Zhang et al.   HUMAN MOLECULAR GENETICS

The complete genome sequence of a Neanderthal from the Altai Mountains

(2013) Kay Prüfer et al.   NATURE

Genetic Adaptation of Fatty-Acid Metabolism: A Human-Specific Haplotype Increasing the Biosynthesis of Long-Chain Omega-3 and Omega-6 Fatty Acids

(2012) Adam Ameur et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Dietary fatty acids and peripheral artery disease in adults

(2012) Asghar Z. Naqvi et al.   ATHEROSCLEROSIS

rehh: an R package to detect footprints of selection in genome-wide SNP data from haplotype structure

(2012) Mathieu Gautier et al.   BIOINFORMATICS

A novelFADS1isoform potentiatesFADS2-mediated production of eicosanoid precursor fatty acids

(2012) Woo Jung Park et al.   JOURNAL OF LIPID RESEARCH

Dietary Linoleic Acid Elevates Endogenous 2-AG and Anandamide and Induces Obesity

(2012) Anita R. Alvheim et al.   Obesity

Adaptive Evolution of the FADS Gene Cluster within Africa

(2012) Rasika A. Mathias et al.   PLoS One

Insertion–deletions in a FADS2 intron 1 conserved regulatory locus control expression of fatty acid desaturases 1 and 2 and modulate response to simvastatin

(2012) Holly T. Reardon et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Docosahexaenoic acid synthesis from alpha-linolenic acid is inhibited by diets high in polyunsaturated fatty acids

(2012) R.A. Gibson et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

A High-Coverage Genome Sequence from an Archaic Denisovan Individual

(2012) M. Meyer et al.   SCIENCE

Characterizing linkage disequilibrium and evaluating imputation power of human genomic insertion-deletion polymorphisms

(2012) James T Lu et al.   GENOME BIOLOGY

Changes in consumption of omega-3 and omega-6 fatty acids in the United States during the 20th century

(2011) Tanya L Blasbalg et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Genome-wide analysis of the transcription factor binding preference of human bi-directional promoters and functional annotation of related gene pairs

(2011) Bingchuan Liu et al.   BMC Systems Biology

Differences in arachidonic acid levels and fatty acid desaturase (FADS) gene variants in African Americans and European Americans with diabetes or the metabolic syndrome

(2011) Susan Sergeant et al.   BRITISH JOURNAL OF NUTRITION

FADS gene variants modulate the effect of dietary fatty acid intake on allergic diseases in children

(2011) M. Standl et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Polyunsaturated fatty acid levels in blood during pregnancy, at birth and at 7 years: their associations with two common FADS2 polymorphisms

(2011) Colin D. Steer et al.   HUMAN MOLECULAR GENETICS

FADS2 Function Loss at the Cancer Hotspot 11q13 Locus Diverts Lipid Signaling Precursor Synthesis to Unusual Eicosanoid Fatty Acids

(2011) Woo Jung Park et al.   PLoS One

Genetic variants in the FADS gene cluster are associated with arachidonic acid concentrations of human breast milk at 1.5 and 6 mo postpartum and influence the course of milk dodecanoic, tetracosenoic, and trans-9-octadecenoic acid concentrations over the duration of lactation

(2010) Eva Lattka et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Single nucleotide polymorphisms in theFADSgene cluster are associated with delta-5 and delta-6 desaturase activities estimated by serum fatty acid ratios

(2010) Szilvia Bokor et al.   JOURNAL OF LIPID RESEARCH

Variants of the FADS1 FADS2 Gene Cluster, Blood Levels of Polyunsaturated Fatty Acids and Eczema in Children within the First 2 Years of Life

(2010) Peter Rzehak et al.   PLoS One

Sequencing of 50 Human Exomes Reveals Adaptation to High Altitude

(2010) X. Yi et al.   SCIENCE

Background Paper on Fat and Fatty Acid Requirements during Pregnancy and Lactation

(2009) J. Thomas Brenna et al.   ANNALS OF NUTRITION AND METABOLISM

The Sequence Alignment/Map format and SAMtools

(2009) H. Li et al.   BIOINFORMATICS

Novel fatty acid desaturase 3 (FADS3) transcripts generated by alternative splicing

(2009) Woo Jung Park et al.   GENE

An alternate pathway to long-chain polyunsaturates: theFADS2gene product Δ8-desaturates 20:2n-6 and 20:3n-3

(2009) Woo Jung Park et al.   JOURNAL OF LIPID RESEARCH

Alternative splicing generates a novel FADS2 alternative transcript in baboons

(2009) Woo Jung Park et al.   MOLECULAR BIOLOGY REPORTS

A genome-wide perspective of genetic variation in human metabolism

(2009) Thomas Illig et al.   NATURE GENETICS

Genome-Wide Association Study of Plasma Polyunsaturated Fatty Acids in the InCHIANTI Study

(2009) Toshiko Tanaka et al.   PLoS Genetics

Genetic Variants of the FADS1 FADS2 Gene Cluster Are Associated with Altered (n-6) and (n-3) Essential Fatty Acids in Plasma and Erythrocyte Phospholipids in Women during Pregnancy and in Breast Milk during Lactation

(2008) Lin Xie et al.   JOURNAL OF NUTRITION

SNPs of the FADS Gene Cluster are Associated with Polyunsaturated Fatty Acids in a Cohort of Patients with Cardiovascular Disease

(2008) Giovanni Malerba et al.   LIPIDS

Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts

(2008) Yurii S Aulchenko et al.   NATURE GENETICS