Recombination Rate Variation, Hitchhiking, and Demographic History Shape Deleterious Load in Poplar

Relative performance of gene- and pathway-level methods as secondary analyses for genome-wide association studies

(2015) Genevieve L Wojcik et al.   BMC GENETICS

The Accumulation of Deleterious Mutations as a Consequence of Domestication and Improvement in Sunflowers and Other Compositae Crops

(2015) Sebastien Renaut et al.   MOLECULAR BIOLOGY AND EVOLUTION

The UK10K project identifies rare variants in health and disease

(2015)   NATURE

Recombination affects accumulation of damaging and disease-associated mutations in human populations

(2015) Julie G Hussin et al.   NATURE GENETICS

SIFT missense predictions for genomes

(2015) Robert Vaser et al.   Nature Protocols

Estimating the mutation load in human genomes

(2015) Brenna M. Henn et al.   NATURE REVIEWS GENETICS

Evidence for extensive parallelism but divergent genomic architecture of adaptation along altitudinal and latitudinal gradients inPopulus trichocarpa

(2015) Jason A. Holliday et al.   NEW PHYTOLOGIST

Recombination in diverse maize is stable, predictable, and associated with genetic load

(2015) Eli Rodgers-Melnick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bottlenecks and selective sweeps during domestication have increased deleterious genetic variation in dogs

(2015) Clare D. Marsden et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distance from sub-Saharan Africa predicts mutational load in diverse human genomes

(2015) Brenna M. Henn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways

(2015) E. T. Cirulli et al.   SCIENCE

Partitioning of multivariate phenotypes using regression trees reveals complex patterns of adaptation to climate across the range of black cottonwood (Populus trichocarpa)

(2015) Regis W. Oubida et al.   Frontiers in Plant Science

Characteristics of Neutral and Deleterious Protein-Coding Variation among Individuals and Populations

(2014) Wenqing Fu et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Whole-Exome Sequencing Identifies Rare and Low-Frequency Coding Variants Associated with LDL Cholesterol

(2014) Leslie A. Lange et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The distribution of deleterious genetic variation in human populations

(2014) Kirk E Lohmueller   CURRENT OPINION IN GENETICS & DEVELOPMENT

The Relation between Recombination Rate and Patterns of Molecular Evolution and Variation in Drosophila melanogaster

(2014) José L. Campos et al.   MOLECULAR BIOLOGY AND EVOLUTION

Exome resequencing reveals signatures of demographic and adaptive processes across the genome and range of black cottonwood (Populus trichocarpa)

(2014) L. Zhou et al.   MOLECULAR ECOLOGY

Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction

(2014) Ron Do et al.   NATURE

The deleterious mutation load is insensitive to recent population history

(2014) Yuval B Simons et al.   NATURE GENETICS

Population genomics of Populus trichocarpa identifies signatures of selection and adaptive trait associations

(2014) Luke M Evans et al.   NATURE GENETICS

LNK1 and LNK2 Are Transcriptional Coactivators in theArabidopsisCircadian Oscillator

(2014) Qiguang Xie et al.   PLANT CELL

Geographical and environmental gradients shape phenotypic trait variation and genetic structure inPopulus trichocarpa

(2013) Athena D. McKown et al.   NEW PHYTOLOGIST

The Pattern and Distribution of Deleterious Mutations in Maize

(2013) Sofiane Mezmouk et al.   G3-Genes Genomes Genetics

Deleterious- and Disease-Allele Prevalence in Healthy Individuals: Insights from Current Predictions, Mutation Databases, and Population-Scale Resequencing

(2012) Yali Xue et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mutation Load: The Fitness of Individuals in Populations Where Deleterious Alleles Are Abundant

(2012) Aneil F. Agrawal et al.   Annual Review of Ecology Evolution and Systematics

Targeted enrichment of the black cottonwood (Populus trichocarpa) gene space using sequence capture

(2012) Lecong Zhou et al.   BMC GENOMICS

Phytochrome Kinase Substrate 4 is phosphorylated by the phototropin 1 photoreceptor

(2012) Emilie Demarsy et al.   EMBO JOURNAL

Rates and Fitness Consequences of New Mutations in Humans

(2012) Peter D. Keightley   GENETICS

Genome resequencing reveals multiscale geographic structure and extensive linkage disequilibrium in the forest treePopulus trichocarpa

(2012) Gancho T. Slavov et al.   NEW PHYTOLOGIST

Predicting the Functional Effect of Amino Acid Substitutions and Indels

(2012) Yongwook Choi et al.   PLoS One

Human population dispersal "Out of Africa" estimated from linkage disequilibrium and allele frequencies of SNPs

(2011) B. P. McEvoy et al.   GENOME RESEARCH

Identification of genes involved in cell wall biogenesis in grasses by differential gene expression profiling of elongating and non-elongating maize internodes

(2011) Maurice Bosch et al.   JOURNAL OF EXPERIMENTAL BOTANY

A framework for variation discovery and genotyping using next-generation DNA sequencing data

(2011) Mark A DePristo et al.   NATURE GENETICS

Whole-genome sequencing of multiple Arabidopsis thaliana populations

(2011) Jun Cao et al.   NATURE GENETICS

Histone modifications and expression of DAM6 gene in peach are modulated during bud dormancy release in a cultivar-dependent manner

(2011) Carmen Leida et al.   NEW PHYTOLOGIST

Chilling of Dormant Buds HyperinducesFLOWERING LOCUS Tand Recruits GA-Inducible 1,3-β-Glucanases to Reopen Signal Conduits and Release Dormancy inPopulus

(2011) Päivi L.H. Rinne et al.   PLANT CELL

Repression of shade-avoidance reactions by sunfleck induction of HY5 expression in Arabidopsis

(2011) Romina Sellaro et al.   PLANT JOURNAL

Evidence for Hitchhiking of Deleterious Mutations within the Human Genome

(2011) Sung Chun et al.   PLoS Genetics

The Functional Genomics of Inbreeding Depression: A New Approach to an Old Problem

(2010) Ken N. Paige   BIOSCIENCE

Genome Wide Analyses Reveal Little Evidence for Adaptive Evolution in Many Plant Species

(2010) T. I. Gossmann et al.   MOLECULAR BIOLOGY AND EVOLUTION

The population genetics of mutations: good, bad and indifferent

(2010) L. Loewe et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Deleterious amino acid polymorphisms in Arabidopsis thaliana and rice

(2010) Torsten Günther et al.   THEORETICAL AND APPLIED GENETICS

Rare Variants Create Synthetic Genome-Wide Associations

(2010) Samuel P. Dickson et al.   PLOS BIOLOGY

The Sequence Alignment/Map format and SAMtools

(2009) H. Li et al.   BIOINFORMATICS

Fast and accurate short read alignment with Burrows-Wheeler transform

(2009) H. Li et al.   BIOINFORMATICS

Reduced Effectiveness of Selection Caused by a Lack of Recombination

(2009) Andrea J. Betancourt et al.   CURRENT BIOLOGY

Gene and pathway-based second-wave analysis of genome-wide association studies

(2009) Gang Peng et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

The genetics of inbreeding depression

(2009) Deborah Charlesworth et al.   NATURE REVIEWS GENETICS

Proportionally more deleterious genetic variation in European than in African populations

(2008) Kirk E. Lohmueller et al.   NATURE

Assessing the Evolutionary Impact of Amino Acid Mutations in the Human Genome

(2008) Adam R. Boyko et al.   PLoS Genetics