Orchestrated feedback regulation between melatonin and sex hormones involving GPER1‐PKA‐CREB signaling in the placenta

Deciphering the placental abnormalities associated with somatic cell nuclear transfer at single-nucleus resolution

(2023) Liyuan Jiang et al.   Protein & Cell

The mystery of the life tree: the placenta

(2022) Xuan Shao et al.   BIOLOGY OF REPRODUCTION

GPER1 is required to protect fetal health from maternal inflammation

(2021) Alfred T. Harding et al.   SCIENCE

Impact of Melatonin on Full-Term Fetal Brain Development and Transforming Growth Factor-β Level in a Rat Model of Preeclampsia

(2021) Nanees Fouad El-Malkey et al.   Reproductive Sciences

Induction of the PPARγ (Peroxisome Proliferator-Activated Receptor γ)-GCM1 (Glial Cell Missing 1) Syncytialization Axis Reduces sFLT1 (Soluble fms-Like Tyrosine Kinase 1) in the Preeclamptic Placenta

(2021) Brooke Armistead et al.   HYPERTENSION

Melatonin-mediated MT2 attenuates colitis induced by dextran sodium sulfate via PI3K/AKT/Nrf2/SIRT1/RORα/NF-κB signaling pathways

(2021) Ting Gao et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

SARS- CoV-2 infection and oxidative stress in early-onset preeclampsia

(2021) Reinaldo Marín et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Melatonin Restores Neutrophil Functions and Prevents Apoptosis amid Dysfunctional Glutathione Redox System

(2020) Somanathapura K. NaveenKumar et al.   JOURNAL OF PINEAL RESEARCH

Melatonin regulates oxidative stress and apoptosis in fetal hearts of pinealectomised RUPP rats

(2020) Oğuzhan Doğanlar et al.   HYPERTENSION IN PREGNANCY

The STRING database in 2021: customizable protein–protein networks, and functional characterization of user-uploaded gene/measurement sets

(2020) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Melatonin regulates the activities of ovary and delays the fertility decline in female animals via MT1/AMPK pathway

(2019) Lu Zhang et al.   JOURNAL OF PINEAL RESEARCH

Melatonin: The smart molecule that differentially modulates autophagy in tumor and normal placental cells

(2019) Lucas Sagrillo-Fagundes et al.   PLoS One

Progesterone-Related Immune Modulation of Pregnancy and Labor

(2019) Nishel M. Shah et al.   Frontiers in Endocrinology

Peripartum infectious morbidity in women with preeclampsia

(2019) Rachel K. Harrison et al.   Journal of Maternal-Fetal & Neonatal Medicine

Melatonin for prevention of placental malperfusion and fetal compromise associated with intrauterine inflammation‐induced oxidative stress in a mouse model

(2019) Ji Yeon Lee et al.   JOURNAL OF PINEAL RESEARCH

Association of imbalanced sex hormone production with excessive procoagulation factor SerpinF2 in preeclampsia

(2018) Xuan Shao et al.   JOURNAL OF HYPERTENSION

Melatonin improves endothelial function in vitro and prolongs pregnancy in women with early-onset preeclampsia

(2018) Sebastian R Hobson et al.   JOURNAL OF PINEAL RESEARCH

Melatonin enhances antioxidant molecules in the placenta, reduces secretion of soluble fms-like tyrosine kinase 1 (sFLT) from primary trophoblast but does not rescue endothelial dysfunction: An evaluation of its potential to treat preeclampsia

(2018) Natalie J. Hannan et al.   PLoS One

Interferons and Proinflammatory Cytokines in Pregnancy and Fetal Development

(2018) Laura J. Yockey et al.   IMMUNITY

Testosterone Represses Estrogen Signaling by Upregulating miR-22Novelty and Significance

(2017) Xuan Shao et al.   HYPERTENSION

Melatonin prevents preeclamptic sera and antiphospholipid antibodies inducing the production of reactive nitrogen species and extrusion of toxic trophoblastic debris from first trimester placentae

(2017) Mingzhi Zhao et al.   PLACENTA

Melatonin up-regulates the expression of the GATA-4 transcription factor and increases testosterone secretion from Leydig cells through RORα signaling in an in vitro goat spermatogonial stem cell differentiation culture system

(2017) Shou-Long Deng et al.   Oncotarget

Lipid droplets and steroidogenic cells

(2016) Wen-Jun Shen et al.   EXPERIMENTAL CELL RESEARCH

Pre-eclampsia

(2016) Ben W J Mol et al.   LANCET

Cell Signaling Pathways Involved During Invasion and Syncytialization of Trophoblast Cells

(2015) Satish Kumar Gupta et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Placental melatonin system is present throughout pregnancy and regulates villous trophoblast differentiation

(2015) Ahmed Soliman et al.   JOURNAL OF PINEAL RESEARCH

Melatonin attenuates methamphetamine-induced neuroinflammation through the melatonin receptor in the SH-SY5Y cell line

(2015) Pawaris Wongprayoon et al.   NEUROTOXICOLOGY

Inhibitory effect of melatonin on testosterone synthesis is mediated via GATA-4/SF-1 transcription factors

(2015) Fenju Qin et al.   REPRODUCTIVE BIOMEDICINE ONLINE

Placental Aromatase Is Deficient in Placental Ischemia and Preeclampsia

(2015) Alejandra Perez-Sepulveda et al.   PLoS One

Safe prevention of the primary cesarean delivery

(2014) Aaron B. Caughey et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Androgens in pregnancy: roles in parturition

(2014) Sofia Makieva et al.   HUMAN REPRODUCTION UPDATE

Clinical relevance of melatonin in ovarian and placental physiology: a review

(2013) Russel J. Reiter et al.   GYNECOLOGICAL ENDOCRINOLOGY

Melatonin and stable circadian rhythms optimize maternal, placental and fetal physiology

(2013) Russel J. Reiter et al.   HUMAN REPRODUCTION UPDATE

A comparison of serum androgens in pre-eclamptic and normotensive pregnant women during the third trimester of pregnancy

(2012) Fatemeh Sharifzadeh et al.   GYNECOLOGICAL ENDOCRINOLOGY

Melatonin modulates TLR4-mediated inflammatory genes through MyD88- and TRIF-dependent signaling pathways in lipopolysaccharide-stimulated RAW264.7 cells

(2012) Mi-Zhen Xia et al.   JOURNAL OF PINEAL RESEARCH

Placental melatonin production and melatonin receptor expression are altered in preeclampsia: new insights into the role of this hormone in pregnancy

(2012) Dave Lanoix et al.   JOURNAL OF PINEAL RESEARCH

Placental trophoblast cell differentiation: Physiological regulation and pathological relevance to preeclampsia

(2012) Lei Ji et al.   MOLECULAR ASPECTS OF MEDICINE

Progesterone synthesis by human placental mitochondria is sensitive to PKA inhibition by H89

(2011) Cuauhtemoc Gomez-Concha et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Melatonin alleviates lipopolysaccharide-induced placental cellular stress response in mice

(2011) Hua Wang et al.   JOURNAL OF PINEAL RESEARCH

Melatonin promotes differentiation of 3T3-L1 fibroblasts

(2011) Alicia González et al.   JOURNAL OF PINEAL RESEARCH

Steroid profiling in preeclamptic women: evidence for aromatase deficiency

(2010) Alexandre Hertig et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Placental efficiency and adaptation: endocrine regulation

(2009) A. L. Fowden et al.   JOURNAL OF PHYSIOLOGY-LONDON

Melatonin affects steroidogenesis and delayed ovulation during winter in vespertilionid bat, Scotophilus heathi

(2009) Raj Kamal Srivastava et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Human placental trophoblasts synthesize melatonin and express its receptors

(2008) Dave Lanoix et al.   JOURNAL OF PINEAL RESEARCH

Oxidative stress impairs oocyte quality and melatonin protects oocytes from free radical damage and improves fertilization rate

(2007) Hiroshi Tamura et al.   JOURNAL OF PINEAL RESEARCH