Melatonin enhances antioxidant molecules in the placenta, reduces secretion of soluble fms-like tyrosine kinase 1 (sFLT) from primary trophoblast but does not rescue endothelial dysfunction: An evaluation of its potential to treat preeclampsia

Resveratrol inhibits release of soluble fms-like tyrosine kinase (sFlt-1) and soluble endoglin and improves vascular dysfunction – implications as a preeclampsia treatment

(2017) Natalie J. Hannan et al.   Scientific Reports

Metformin as a prevention and treatment for preeclampsia: effects on soluble fms-like tyrosine kinase 1 and soluble endoglin secretion and endothelial dysfunction

(2016) Fiona C. Brownfoot et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

The protective effect of melatonin on smoke-induced vascular injury in rats and humans: a randomized controlled trial

(2016) Zhanqi Wang et al.   JOURNAL OF PINEAL RESEARCH

The effects of hydroxychloroquine on endothelial dysfunction

(2016) Rahana Rahman et al.   Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health

Heme Oxygenase-1 Is Not Decreased in Preeclamptic Placenta and Does Not Negatively Regulate Placental Soluble fms-Like Tyrosine Kinase-1 or Soluble Endoglin SecretionNovelty and Significance

(2015) Stephen Tong et al.   HYPERTENSION

Effects of Pravastatin on Human Placenta, Endothelium, and Women With Severe PreeclampsiaNovelty and Significance

(2015) Fiona C. Brownfoot et al.   HYPERTENSION

Sofalcone Upregulates the Nuclear Factor (Erythroid-Derived 2)-Like 2/Heme Oxygenase-1 Pathway, Reduces Soluble fms-Like Tyrosine Kinase-1, and Quenches Endothelial Dysfunction: Potential Therapeutic for Preeclampsia

(2015) K. Onda et al.   HYPERTENSION

Placental melatonin system is present throughout pregnancy and regulates villous trophoblast differentiation

(2015) Ahmed Soliman et al.   JOURNAL OF PINEAL RESEARCH

Characterization of protocols for primary trophoblast purification, optimized for functional investigation of sFlt-1 and soluble endoglin

(2014) Tu’uhevaha J. Kaitu’u-Lino et al.   Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health

Melatonin ameliorates endothelial dysfunction, vascular inflammation, and systemic hypertension in rats with chronic intermittent hypoxia

(2013) Ming-Wai Hung et al.   JOURNAL OF PINEAL RESEARCH

Melatonin: The watchdog of villous trophoblast homeostasis against hypoxia/reoxygenation-induced oxidative stress and apoptosis

(2013) Dave Lanoix et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Phase I pilot clinical trial of antenatal maternally administered melatonin to decrease the level of oxidative stress in human pregnancies affected by pre-eclampsia (PAMPR): study protocol

(2013) Sebastian R Hobson et al.   BMJ Open

Placental melatonin production and melatonin receptor expression are altered in preeclampsia: new insights into the role of this hormone in pregnancy

(2012) Dave Lanoix et al.   JOURNAL OF PINEAL RESEARCH

Antioxidant Therapies: A Potential Role in Perinatal Medicine

(2012) S.L. Miller et al.   NEUROENDOCRINOLOGY

Preeclampsia, a Disease of the Maternal Endothelium

(2011) Camille E. Powe et al.   CIRCULATION

Melatonin: The smart killer

(2011) Dave Lanoix et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Pathogenesis of Preeclampsia

(2010) Brett C. Young et al.   Annual Review of Pathology-Mechanisms of Disease

Soluble FLT1 sensitizes endothelial cells to inflammatory cytokines by antagonizing VEGF receptor-mediated signalling

(2010) T. Cindrova-Davies et al.   CARDIOVASCULAR RESEARCH

Preeclampsia and the anti-angiogenic state

(2010) Isha Agarwal et al.   Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health

Melatonin improves placental efficiency and birth weight and increases the placental expression of antioxidant enzymes in undernourished pregnancy

(2009) Hans G. Richter et al.   JOURNAL OF PINEAL RESEARCH

Human placental trophoblasts synthesize melatonin and express its receptors

(2008) Dave Lanoix et al.   JOURNAL OF PINEAL RESEARCH

Melatonin preserves fetal growth in rats by protecting against ischemia/reperfusion-induced oxidative/nitrosative mitochondrial damage in the placenta

(2008) Ryuhei Nagai et al.   JOURNAL OF PINEAL RESEARCH