Biosynthesis of neuroprotective melatonin is dysregulated in Huntington's disease

Two hit mitochondrial-driven model of synapse loss in neurodegeneration

(2021) Sergei V. Baranov et al.   NEUROBIOLOGY OF DISEASE

Melatonin inhibits cytosolic mitochondrial DNA–induced neuroinflammatory signaling in accelerated aging and neurodegeneration

(2020) Abhishek Jauhari et al.   JOURNAL OF CLINICAL INVESTIGATION

Cyclic GMP-AMP synthase promotes the inflammatory and autophagy responses in Huntington disease

(2020) Manish Sharma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutant huntingtin disrupts mitochondrial proteostasis by interacting with TIM23

(2019) Svitlana Yablonska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiple clinical features of Huntington’s disease correlate with mutant HTT gene CAG repeat lengths and neurodegeneration

(2018) Sonia Podvin et al.   JOURNAL OF NEUROLOGY

Pathophysiology in the suprachiasmatic nucleus in mouse models of Huntington’s disease

(2018) Dika Kuljis et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Mitochondria modulate programmed neuritic retraction

(2018) Sergei V. Baranov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release

(2017) Yalikun Suofu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reactive Oxygen Species: Stuck in the Middle of Neurodegeneration

(2017) David A. Patten et al.   JOURNAL OF ALZHEIMERS DISEASE

Melatonin as an Antioxidant for Stroke Neuroprotection

(2016) Nate Watson et al.   CELL TRANSPLANTATION

Problem solving, impulse control and planning in patients with early- and late-stage Huntington’s disease

(2016) Sabrina Mörkl et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

Sex Differences in Circadian Dysfunction in the BACHD Mouse Model of Huntington’s Disease

(2016) Dika A. Kuljis et al.   PLoS One

Melatonin treatment improves primary progressive multiple sclerosis: a case report

(2015) Antonio López-González et al.   JOURNAL OF PINEAL RESEARCH

Melatonin ameliorates amyloid beta-induced memory deficits, tau hyperphosphorylation and neurodegeneration via PI3/Akt/GSk3β pathway in the mouse hippocampus

(2015) Tahir Ali et al.   JOURNAL OF PINEAL RESEARCH

Extrapineal melatonin: sources, regulation, and potential functions

(2014) Darío Acuña-Castroviejo et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Plasma melatonin is reduced in Huntington's disease

(2014) Eirini Kalliolia et al.   MOVEMENT DISORDERS

Inhibition of mitochondrial protein import by mutant huntingtin

(2014) Hiroko Yano et al.   NATURE NEUROSCIENCE

Correlations between behavioural and oxidative parameters in a rat quinolinic acid model of Huntington’s disease: Protective effect of melatonin

(2013) Ethel Antunes Wilhelm et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Melatonin inhibits the caspase-1/cytochrome c/caspase-3 cell death pathway, inhibits MT1 receptor loss and delays disease progression in a mouse model of amyotrophic lateral sclerosis

(2013) Yi Zhang et al.   NEUROBIOLOGY OF DISEASE

The Melatonin MT1 Receptor Axis Modulates Mutant Huntingtin-Mediated Toxicity

(2011) X. Wang et al.   JOURNAL OF NEUROSCIENCE

Extrapineal melatonin: analysis of its subcellular distribution and daily fluctuations

(2011) Carmen Venegas et al.   JOURNAL OF PINEAL RESEARCH

Genetic variation of melatonin productivity in laboratory mice under domestication

(2010) T. Kasahara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural and Functional Evolution of the Pineal Melatonin System in Vertebrates

(2009) Jack Falcón et al.   Annals of the New York Academy of Sciences

Delayed onset of the diurnal melatonin rise in patients with Huntington’s disease

(2009) N. Ahmad Aziz et al.   JOURNAL OF NEUROLOGY

Methazolamide and Melatonin Inhibit Mitochondrial Cytochrome C Release and Are Neuroprotective in Experimental Models of Ischemic Injury

(2009) Xin Wang et al.   STROKE

Decreased MT1 and MT2 melatonin receptor expression in extrapineal tissues of the rat during physiological aging

(2008) Marina Sánchez-Hidalgo et al.   JOURNAL OF PINEAL RESEARCH