Recombinant Slit2 suppresses neuroinflammation and Cdc42-mediated brain infiltration of peripheral immune cells via Robo1–srGAP1 pathway in a rat model of germinal matrix hemorrhage

Targeting NLRP3 inflammasome modulates gut microbiota, attenuates corticospinal tract injury and ameliorates neurobehavioral deficits after intracerebral hemorrhage in mice

(2022) Linglong Xiao et al.   BIOMEDICINE & PHARMACOTHERAPY

Temporal brain transcriptome analysis reveals key pathological events after germinal matrix hemorrhage in neonatal rats

(2022) Juan Song et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Neuroinflammation, Stroke, Blood-Brain Barrier Dysfunction, and Imaging Modalities

(2022) Eduardo Candelario-Jalil et al.   STROKE

Vitamin D Enhances Hematoma Clearance and Neurologic Recovery in Intracerebral Hemorrhage

(2022) Jiaxin Liu et al.   STROKE

Mechanisms of neuroinflammation in hydrocephalus after intraventricular hemorrhage: a review

(2022) Katherine G. Holste et al.   Fluids and Barriers of the CNS

Inflammatory and oxidative stress markers in intracerebral hemorrhage: Relevance as prognostic markers for quantification of the edema volume

(2022) Vladimir Rendevski et al.   BRAIN PATHOLOGY

White matter injury in infants with intraventricular haemorrhage: mechanisms and therapies

(2021) Praveen Ballabh et al.   Nature Reviews Neurology

The Drosophila melanogaster Levodopa-Induced Depression Model Exhibits Negative Geotaxis Deficits and Differential Gene Expression in Males and Females

(2021) Thiago C. Moulin et al.   Frontiers in Neuroscience

The Therapeutic Role of Slit2 in Anti-fibrosis, Anti-inflammation and Anti-oxidative Stress in Rats with Coronary Heart Disease

(2021) Ji-Wei Liu et al.   Cardiovascular Toxicology

Preterm Intraventricular Hemorrhage-Induced Inflammatory Response in Human Choroid Plexus Epithelial Cells

(2021) Zsolt Fejes et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Aminophylline modulates the permeability of endothelial cells via the Slit2‑Robo4 pathway in lipopolysaccharide‑induced inflammation

(2021) Qin Chen et al.   Experimental and Therapeutic Medicine

The potential of Slit2 as a therapeutic target for central nervous system disorders

(2020) Prativa Sherchan et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Potential therapeutic targets for intracerebral hemorrhage-associated inflammation: An update

(2020) Honglei Ren et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

NT-4 attenuates neuroinflammation via TrkB/PI3K/FoxO1 pathway after germinal matrix hemorrhage in neonatal rats

(2020) Tianyi Wang et al.   Journal of Neuroinflammation

Serelaxin activates eNOS, suppresses inflammation, attenuates developmental delay and improves cognitive functions of neonatal rats after germinal matrix hemorrhage

(2020) Ming M. Xu et al.   Scientific Reports

A new neutrophil subset promotes CNS neuron survival and axon regeneration

(2020) Andrew R. Sas et al.   NATURE IMMUNOLOGY

High glucose alters the DNA methylation pattern of neurodevelopment associated genes in human neural progenitor cells in vitro

(2020) Deepika Kandilya et al.   Scientific Reports

Erythropoietin Improves Atrophy, Bleeding and Cognition in the Newborn Intraventricular Hemorrhage

(2020) Carmen Hierro-Bujalance et al.   Frontiers in Cell and Developmental Biology

Peripheral inflammation and blood–brain barrier disruption: effects and mechanisms

(2020) Xiaowen Huang et al.   CNS Neuroscience & Therapeutics

Neuronal NADPH oxidase 2 regulates growth cone guidance downstream of slit2/robo2

(2020) Aslihan Terzi et al.   Developmental Neurobiology

Robust alternative to the righting reflex to assess arousal in rodents

(2020) Sijia Gao et al.   Scientific Reports

Crosstalk between the activated Slit2–Robo1 pathway and TGF‐β1 signalling promotes cardiac fibrosis

(2020) Yunqi Liu et al.   ESC Heart Failure

Rh-IFN-α attenuates neuroinflammation and improves neurological function by inhibiting NF-κB through JAK1-STAT1/TRAF3 pathway in an experimental GMH rat model

(2019) Peng Li et al.   BRAIN BEHAVIOR AND IMMUNITY

SLIT2 inhibits osteoclastogenesis and bone resorption by suppression of Cdc42 activity

(2019) So Jeong Park et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Microglial TREM-1 receptor mediates neuroinflammatory injury via interaction with SYK in experimental ischemic stroke

(2019) Pengfei Xu et al.   Cell Death & Disease

Hyaluronidase reduced edema after experimental traumatic brain injury

(2019) Patricia M Washington et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Recombinant Slit2 attenuates neuronal apoptosis via the Robo1-srGAP1 pathway in a rat model of neonatal HIE

(2019) Harpreet Kaur et al.   NEUROPHARMACOLOGY

Slit2/Robo1 signaling is involved in angiogenesis of glomerular endothelial cells exposed to a diabetic-like environment

(2018) Junhui Liu et al.   ANGIOGENESIS

Rho GTPases in Intellectual Disability: From Genetics to Therapeutic Opportunities

(2018) Valentina Zamboni et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Robo1 and vimentin regulate radiation-induced motility of human glioblastoma cells

(2018) Pascaline Nguemgo Kouam et al.   PLoS One

Slit2/Robo4 signaling pathway modulates endothelial hyper-permeability in a two-event in vitro model of transfusion-related acute lung injury

(2018) Jie Weng et al.   BLOOD CELLS MOLECULES AND DISEASES

Different Isoforms of the Neuronal Guidance Molecule Slit2 Directly Cause Chemoattraction or Chemorepulsion of Human Neutrophils

(2018) Darrell Pilling et al.   JOURNAL OF IMMUNOLOGY

Differential expression levels and methylation status of ROBO1 in mantle cell lymphoma and chronic lymphocytic leukaemia

(2016) A. J. Appe et al.   International Journal of Laboratory Hematology

Recombinant N-Terminal Slit2 Inhibits TGF- -Induced Fibroblast Activation and Renal Fibrosis

(2016) D. A. Yuen et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Recombinant Slit2 attenuates neuroinflammation after surgical brain injury by inhibiting peripheral immune cell infiltration via Robo1-srGAP1 pathway in a rat model

(2016) Prativa Sherchan et al.   NEUROBIOLOGY OF DISEASE

Inflammation and Stroke: An Overview

(2016) Josef Anrather et al.   Neurotherapeutics

Modulating the Immune Response Towards a Neuroregenerative Peri-injury Milieu After Cerebral Hemorrhage

(2015) Damon Klebe et al.   Journal of Neuroimmune Pharmacology

Nkx2.1-derived astrocytes and neurons together with Slit2 are indispensable for anterior commissure formation

(2015) Shilpi Minocha et al.   Nature Communications

Roundabout 1 exists predominantly as a basal dimeric complex and this is unaffected by binding of the ligand Slit2

(2014) Linas Zakrys et al.   BIOCHEMICAL JOURNAL

Axon Guidance Factor SLIT2 Inhibits Neural Invasion and Metastasis in Pancreatic Cancer

(2014) A. Gohrig et al.   CANCER RESEARCH

Robo1 Modulates Proliferation and Neurogenesis in the Developing Neocortex

(2014) M. L. Yeh et al.   JOURNAL OF NEUROSCIENCE

Slit2 promotes tumor growth and invasion in chemically induced skin carcinogenesis

(2014) Cuiling Qi et al.   LABORATORY INVESTIGATION

Slit2-Robo signaling in inflammation and kidney injury

(2014) Swasti Chaturvedi et al.   PEDIATRIC NEPHROLOGY

Neutrophils and stroke – Can neutrophils mitigate disease in the central nervous system?

(2013) Alexander S. Easton   INTERNATIONAL IMMUNOPHARMACOLOGY

Slit2-Robo4 Pathway Modulates Lipopolysaccharide-Induced Endothelial Inflammation and Its Expression Is Dysregulated during Endotoxemia

(2013) H. Zhao et al.   JOURNAL OF IMMUNOLOGY

Cerebral endothelial expression of Robo1 affects brain infiltration of polymorphonuclear neutrophils during mouse stroke recovery

(2013) Sandhya Gangaraju et al.   NEUROBIOLOGY OF DISEASE

Inflammation in intracerebral hemorrhage: From mechanisms to clinical translation

(2013) Yu Zhou et al.   PROGRESS IN NEUROBIOLOGY

Rodent neonatal germinal matrix hemorrhage mimics the human brain injury, neurological consequences, and post-hemorrhagic hydrocephalus

(2012) Tim Lekic et al.   EXPERIMENTAL NEUROLOGY

Molecular Pathophysiology of Cerebral Hemorrhage

(2011) Jaroslaw Aronowski et al.   STROKE

Slit2 Regulates Attractive Eosinophil and Repulsive Neutrophil Chemotaxis through Differential srGAP1 Expression during Lung Inflammation

(2010) B.-Q. Ye et al.   JOURNAL OF IMMUNOLOGY

Cooperative Signaling between Slit2 and Ephrin-A1 Regulates a Balance between Angiogenesis and Angiostasis

(2010) C. M. Dunaway et al.   MOLECULAR AND CELLULAR BIOLOGY

Targeting Robo4-Dependent Slit Signaling to Survive the Cytokine Storm in Sepsis and Influenza

(2010) N. R. London et al.   Science Translational Medicine

The axonal repellent, Slit2, inhibits directional migration of circulating neutrophils

(2009) Soumitra Tole et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Slit2 inhibits glioma cell invasion in the brain by suppression of Cdc42 activity

(2009) Jia-Jean Yiin et al.   NEURO-ONCOLOGY

Slits and Roundabouts in cancer, tumour angiogenesis and endothelial cell migration

(2008) John A. Legg et al.   ANGIOGENESIS