Elucidating the Therapeutic Utility of Olaparib in Sulfatide-Induced Human Astrocyte Toxicity and Neuroinflammation

Existing Evidence for the Repurposing of PARP-1 Inhibitors in Rare Demyelinating Diseases

(2022) Marianna Mekhaeil et al.   Cancers

The Role of PARPs in Inflammation—and Metabolic—Related Diseases: Molecular Mechanisms and Beyond

(2019) Ke et al.   Cells

PARP Inhibition in Cancer: An Update on Clinical Development

(2019) Esha Sachdev et al.   Targeted Oncology

Inhibiting poly ADP-ribosylation increases fatty acid oxidation and protects against fatty liver disease

(2017) Karim Gariani et al.   JOURNAL OF HEPATOLOGY

Oligodendroglial myelination requires astrocyte-derived lipids

(2017) Nutabi Camargo et al.   PLOS BIOLOGY

Gene therapy for metachromatic leukodystrophy

(2016) Jonathan B. Rosenberg et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Cerebral Spinal Fluid levels of Cytokines are elevated in Patients with Metachromatic Leukodystrophy

(2016) Kathryn A. Thibert et al.   Scientific Reports

Poly(ADP-Ribose)Polymerase 1 (PARP-1) Activation and Ca2+ Permeable α-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic Acid (AMPA) Channels in Post-Ischemic Brain Damage: New Therapeutic Opportunities?

(2015) Elisabetta Gerace et al.   CNS & Neurological Disorders-Drug Targets

Biology of Poly(ADP-Ribose) Polymerases: The Factotums of Cell Maintenance

(2015) Peter Bai   MOLECULAR CELL

Control of autoimmune CNS inflammation by astrocytes

(2015) Veit Rothhammer et al.   Seminars in Immunopathology

The selective anti-IL17A monoclonal antibody secukinumab (AIN457) attenuates IL17A-induced levels of IL6 in human astrocytes

(2014) Gaelle Elain et al.   GLIA

EBI2 regulates intracellular signaling and migration in human astrocyte

(2014) Aleksandra Rutkowska et al.   GLIA

Targeting poly(ADP-ribose)polymerase1 in neurological diseases: A promising trove for new pharmacological interventions to enter clinical translation

(2014) Chandra Shekhar Sriram et al.   NEUROCHEMISTRY INTERNATIONAL

PARP-1: Friend or Foe of DNA Damage and Repair in Tumorigenesis?

(2013) Amanda Swindall et al.   Cancers

Structural Implications for Selective Targeting of PARPs

(2013) Jamin D. Steffen et al.   Frontiers in Oncology

Role of sulfatide in normal and pathological cells and tissues

(2012) Tadanobu Takahashi et al.   JOURNAL OF LIPID RESEARCH

Inflammation induced by innate immunity in the central nervous system leads to primary astrocyte dysfunction followed by demyelination

(2010) Rakhi Sharma et al.   ACTA NEUROPATHOLOGICA

NAD+ Depletion Is Necessary and Sufficient forPoly(ADP-Ribose) Polymerase-1-Mediated Neuronal Death

(2010) C. C. Alano et al.   JOURNAL OF NEUROSCIENCE

Metachromatic leukodystrophy - mutation analysis provides further evidence of genotype-phenotype correlation

(2009) A Biffi et al.   CLINICAL GENETICS

Calcium dysregulation induces apoptosis-inducing factor release: Cross-talk between PARP-1- and calpain- signaling pathways

(2009) Peter S. Vosler et al.   EXPERIMENTAL NEUROLOGY

Calcium signaling and neurodegenerative diseases

(2009) Ilya Bezprozvanny   TRENDS IN MOLECULAR MEDICINE