Multidimensional Proteomics Reveals a Role of UHRF2 in the Regulation of Epithelial-Mesenchymal Transition (EMT)

UHRF1 Overexpression Drives DNA Hypomethylation and Hepatocellular Carcinoma

(2014) Raksha Mudbhary et al.   CANCER CELL

Dissecting Engineered Cell Types and Enhancing Cell Fate Conversion via CellNet

(2014) Samantha A. Morris et al.   CELL

CellNet: Network Biology Applied to Stem Cell Engineering

(2014) Patrick Cahan et al.   CELL

Structural Basis for Hydroxymethylcytosine Recognition by the SRA Domain of UHRF2

(2014) Ting Zhou et al.   MOLECULAR CELL

Nucleotide Biosynthetic Enzyme GMP Synthase Is a TRIM21-Controlled Relay of p53 Stabilization

(2014) B. Ashok Reddy et al.   MOLECULAR CELL

Proteogenomic characterization of human colon and rectal cancer

(2014) Bing Zhang et al.   NATURE

Oncogenic roles of EMT-inducing transcription factors

(2014) Alain Puisieux et al.   NATURE CELL BIOLOGY

Molecular mechanisms of epithelial–mesenchymal transition

(2014) Samy Lamouille et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

UHRF2 mRNA Expression is Low in Malignant Glioma but Silencing Inhibits the Growth of U251 Glioma Cells in vitro

(2013) Ting-Feng Wu et al.   Asian Pacific Journal of Cancer Prevention

Increasing role of UHRF1 in the reading and inheritance of the epigenetic code as well as in tumorogenesis

(2013) Christian Bronner et al.   BIOCHEMICAL PHARMACOLOGY

Dynamic Readers for 5-(Hydroxy)Methylcytosine and Its Oxidized Derivatives

(2013) Cornelia G. Spruijt et al.   CELL

Regulation of UHRF1 by miR-146a/b modulates gastric cancer invasion and metastasis

(2013) Lin Zhou et al.   FASEB JOURNAL

UHRF2, a Ubiquitin E3 Ligase, Acts as a Small Ubiquitin-like Modifier E3 Ligase for Zinc Finger Protein 131

(2013) Yohan Oh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Fast Workflow for Identification and Quantification of Proteomes

(2013) Chen Ding et al.   MOLECULAR & CELLULAR PROTEOMICS

The epigenetics of epithelial-mesenchymal plasticity in cancer

(2013) Wai Leong Tam et al.   NATURE MEDICINE

Proteome-wide profiling of activated transcription factors with a concatenated tandem array of transcription factor response elements

(2013) C. Ding et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NIRF/UHRF2 occupies a central position in the cell cycle network and allows coupling with the epigenetic landscape

(2012) Tsutomu Mori et al.   FEBS LETTERS

Structural Insight into Coordinated Recognition of Trimethylated Histone H3 Lysine 9 (H3K9me3) by the Plant Homeodomain (PHD) and Tandem Tudor Domain (TTD) of UHRF1 (Ubiquitin-like, Containing PHD and RING Finger Domains, 1) Protein

(2012) Jingdong Cheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Association of UHRF1 with methylated H3K9 directs the maintenance of DNA methylation

(2012) Scott B Rothbart et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The epigenetic regulator UHRF1 promotes ubiquitination-mediated degradation of the tumor-suppressor protein promyelocytic leukemia protein

(2012) D Guan et al.   ONCOGENE

The SRA protein UHRF1 promotes epigenetic crosstalks and is involved in prostate cancer progression

(2012) F Babbio et al.   ONCOGENE

Recognition of modification status on a histone H3 tail by linked histone reader modules of the epigenetic regulator UHRF1

(2012) K. Arita et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular networks that regulate cancer metastasis

(2012) Daniela Spano et al.   SEMINARS IN CANCER BIOLOGY

NIRF, a novel ubiquitin ligase, interacts with hepatitis B virus core protein and promotes its degradation

(2011) Guanhua Qian et al.   BIOTECHNOLOGY LETTERS

NIRF is frequently upregulated in colorectal cancer and its oncogenicity can be suppressed by let-7a microRNA

(2011) Feng Wang et al.   CANCER LETTERS

NIRF constitutes a nodal point in the cell cycle network and is a candidate tumor suppressor

(2011) Tsutomu Mori et al.   CELL CYCLE

S phase-dependent interaction with DNMT1 dictates the role of UHRF1 but not UHRF2 in DNA methylation maintenance

(2011) Jiqin Zhang et al.   CELL RESEARCH

TCF12 Protein Functions as Transcriptional Repressor of E-cadherin, and Its Overexpression Is Correlated with Metastasis of Colorectal Cancer

(2011) Chun-Chung Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recognition of Multivalent Histone States Associated with Heterochromatin by UHRF1 Protein

(2011) Nataliya Nady et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

UHRF1 Double Tudor Domain and the Adjacent PHD Finger Act Together to Recognize K9me3-Containing Histone H3 Tail

(2011) Si Xie et al.   JOURNAL OF MOLECULAR BIOLOGY

Identification and functional analysis of 9p24 amplified genes in human breast cancer

(2011) J Wu et al.   ONCOGENE

 -catenin/TCF4 complex induces the epithelial-to-mesenchymal transition (EMT)-activator ZEB1 to regulate tumor invasiveness

(2011) E. Sanchez-Tillo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

UHRF1 is a novel diagnostic marker of lung cancer

(2010) M Unoki et al.   BRITISH JOURNAL OF CANCER

An Oct4-Centered Protein Interaction Network in Embryonic Stem Cells

(2010) Debbie L.C. van den Berg et al.   Cell Stem Cell

Usp7 and Uhrf1 control ubiquitination and stability of the maintenance DNA methyltransferase Dnmt1

(2010) Weihua Qin et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

DNMT1 Stability Is Regulated by Proteins Coordinating Deubiquitination and Acetylation-Driven Ubiquitination

(2010) Z. Du et al.   Science Signaling

Drug discovery targeting epigenetic codes: The great potential of UHRF1, which links DNA methylation and histone modifications, as a drug target in cancers and toxoplasmosis

(2009) Motoko Unoki et al.   BIOCHEMICAL PHARMACOLOGY

UHRF1 is a novel molecular marker for diagnosis and the prognosis of bladder cancer

(2009) M Unoki et al.   BRITISH JOURNAL OF CANCER

Intranuclear Degradation of Polyglutamine Aggregates by the Ubiquitin-Proteasome System

(2009) Atsushi Iwata et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The multi-domain protein Np95 connects DNA methylation and histone modification

(2009) Andrea Rottach et al.   NUCLEIC ACIDS RESEARCH

Structure and Hemimethylated CpG Binding of the SRA Domain from Human UHRF1

(2008) Chengmin Qian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The SRA domain of UHRF1 flips 5-methylcytosine out of the DNA helix

(2008) Hideharu Hashimoto et al.   NATURE

Recognition of hemi-methylated DNA by the SRA protein UHRF1 by a base-flipping mechanism

(2008) Kyohei Arita et al.   NATURE

Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1

(2008) George V. Avvakumov et al.   NATURE