Activation of neurokinin-III receptors modulates human atrial TASK-1 currents

Atrial fibrillation in the presence and absence of heart failure enhances expression of genes involved in cardiomyocyte structure, conduction properties, fibrosis, inflammation, and endothelial dysfunction

(2022) Stef Zeemering et al.   HEART RHYTHM

The Experimental TASK-1 Potassium Channel Inhibitor A293 Can Be Employed for Rhythm Control of Persistent Atrial Fibrillation in a Translational Large Animal Model

(2021) Felix Wiedmann et al.   Frontiers in Physiology

Small Conductance Ca2 +-Activated K+ (SK) Channel mRNA Expression in Human Atrial and Ventricular Tissue: Comparison Between Donor, Atrial Fibrillation and Heart Failure Tissue

(2021) Elisa Darkow et al.   Frontiers in Physiology

Two-Pore-Domain Potassium (K2P-) Channels: Cardiac Expression Patterns and Disease-Specific Remodelling Processes

(2021) Felix Wiedmann et al.   Cells

A lower X-gate in TASK channels traps inhibitors within the vestibule

(2020) Karin E. J. Rödström et al.   NATURE

Pharmacologic TWIK‐Related Acid‐Sensitive K+ Channel (TASK‐1) Potassium Channel Inhibitor A293 Facilitates Acute Cardioversion of Paroxysmal Atrial Fibrillation in a Porcine Large Animal Model

(2020) Felix Wiedmann et al.   Journal of the American Heart Association

Genetic Ablation of TASK-1 (Tandem of P Domains in a Weak Inward Rectifying K + Channel–Related Acid-Sensitive K + Channel-1) (K 2P 3.1) K + Channels Suppresses Atrial Fibrillation and Prevents Electrical Remodeling

(2019) Constanze Schmidt et al.   Circulation-Arrhythmia and Electrophysiology

N-Glycosylation of TREK-1/hK2P2.1 Two-Pore-Domain Potassium (K2P) Channels

(2019) Felix Wiedmann et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Atrial fibrillation and heart failure-associated remodeling of two-pore-domain potassium (K2P) channels in murine disease models: focus on TASK-1

(2018) Felix Wiedmann et al.   BASIC RESEARCH IN CARDIOLOGY

Role of autonomic nervous system in atrial fibrillation

(2018) Dominik Linz et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Neurokinin-3 receptor activation selectively prolongs atrial refractoriness by inhibition of a background K+ channel

(2018) Marieke W. Veldkamp et al.   Nature Communications

The two-pore domain potassium channel, TWIK-1, has a role in the regulation of heart rate and atrial size

(2016) Alex Hørby Christensen et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Ganglion Plexus Ablation in Advanced Atrial Fibrillation

(2016) Antoine H.G. Driessen et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Upregulation of K2P3.1 K+Current Causes Action Potential Shortening in Patients With Chronic Atrial FibrillationCLINICAL PERSPECTIVE

(2015) Constanze Schmidt et al.   CIRCULATION

TASK-1 and TASK-3 may form heterodimers in human atrial cardiomyocytes

(2015) Susanne Rinné et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome

(2015) Wesley K Kroeze et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome

(2015) Wesley K Kroeze et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Substance P Depolarizes Lamprey Spinal Cord Neurons by Inhibiting Background Potassium Channels

(2015) Carolina Thörn Pérez et al.   PLoS One

Cloning, functional characterization, and remodeling of K2P3.1 (TASK-1) potassium channels in a porcine model of atrial fibrillation and heart failure

(2014) Constanze Schmidt et al.   HEART RHYTHM

Genetic variation in the two-pore domain potassium channel, TASK-1, may contribute to an atrial substrate for arrhythmogenesis

(2014) Bo Liang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

SWISS-MODEL: modelling protein tertiary and quaternary structure using evolutionary information

(2014) Marco Biasini et al.   NUCLEIC ACIDS RESEARCH

Diacylglycerol mediates regulation of TASK potassium channels by Gq-coupled receptors

(2014) Bettina U. Wilke et al.   Nature Communications

Neuropeptide Substance-P Modulates Electrical Characteristics of Rabbit Atrial Myocytes

(2013) Guillaume S.C. Geuzebroek et al.   BIOPHYSICAL JOURNAL

Ganglionated plexus ablation vs linear ablation in patients undergoing pulmonary vein isolation for persistent/long-standing persistent atrial fibrillation: A randomized comparison

(2013) Evgeny Pokushalov et al.   HEART RHYTHM

Autonomic Denervation Added to Pulmonary Vein Isolation for Paroxysmal Atrial Fibrillation

(2013) Demosthenes G. Katritsis et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The inhibition of the potassium channel TASK-1 in rat cardiac muscle by endothelin-1 is mediated by phospholipase C

(2012) Julia Schiekel et al.   CARDIOVASCULAR RESEARCH

Signalling between G-protein-coupled receptors and TASK1 channels

(2012) Kanigula Mubagwa   CARDIOVASCULAR RESEARCH

TASK-1 Channels May Modulate Action Potential Duration of Human Atrial Cardiomyocytes

(2011) Sven H. Limberg et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Neurotensin inhibits background K+ channels and facilitates glutamatergic transmission in rat spinal cord dorsal horn

(2011) Nabila Kadiri et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Pathophysiological Mechanisms of Atrial Fibrillation: A Translational Appraisal

(2011) Ulrich Schotten et al.   PHYSIOLOGICAL REVIEWS

Automated comparative protein structure modeling with SWISS-MODEL and Swiss-PdbViewer: A historical perspective

(2010) Nicolas Guex et al.   ELECTROPHORESIS

Regulation of two-pore-domain (K2P) potassium leak channels by the tyrosine kinase inhibitor genistein

(2008) J Gierten et al.   BRITISH JOURNAL OF PHARMACOLOGY

The SWISS-MODEL Repository and associated resources

(2008) F. Kiefer et al.   NUCLEIC ACIDS RESEARCH