Challenges and Prospects in Developing Future SARS-CoV-2 Vaccines: Overcoming Original Antigenic Sin and Inducing Broadly Neutralizing Antibodies
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Title
Challenges and Prospects in Developing Future SARS-CoV-2 Vaccines: Overcoming Original Antigenic Sin and Inducing Broadly Neutralizing Antibodies
Authors
Keywords
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Journal
JOURNAL OF IMMUNOLOGY
Volume 211, Issue 10, Pages 1459-1467
Publisher
The American Association of Immunologists
Online
2023-11-07
DOI
10.4049/jimmunol.2300315
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Note: Only part of the references are listed.- Molecular fate-mapping of serum antibody responses to repeat immunization
- (2023) Ariën Schiepers et al. NATURE
- Neutralization of BA.4–BA.5, BA.4.6, BA.2.75.2, BQ.1.1, and XBB.1 with Bivalent Vaccine
- (2023) Jing Zou et al. NEW ENGLAND JOURNAL OF MEDICINE
- Effectiveness of Bivalent Boosters against Severe Omicron Infection
- (2023) Dan-Yu Lin et al. NEW ENGLAND JOURNAL OF MEDICINE
- Bivalent Omicron BA.1–Adapted BNT162b2 Booster in Adults Older than 55 Years
- (2023) Patricia Winokur et al. NEW ENGLAND JOURNAL OF MEDICINE
- Immunogenicity of BA.5 Bivalent mRNA Vaccine Boosters
- (2023) Ai-ris Y. Collier et al. NEW ENGLAND JOURNAL OF MEDICINE
- Antibody Response to Omicron BA.4–BA.5 Bivalent Booster
- (2023) Qian Wang et al. NEW ENGLAND JOURNAL OF MEDICINE
- Enhanced evasion of neutralizing antibody response by Omicron XBB.1.5, CH.1.1, and CA.3.1 variants
- (2023) Panke Qu et al. Cell Reports
- Live-attenuated vaccine sCPD9 elicits superior mucosal and systemic immunity to SARS-CoV-2 variants in hamsters
- (2023) Geraldine Nouailles et al. Nature Microbiology
- Comparison of bivalent and monovalent SARS-CoV-2 variant vaccines: the phase 2 randomized open-label COVAIL trial
- (2023) Angela R. Branche et al. NATURE MEDICINE
- Immune imprinting, breadth of variant recognition, and germinal center response in human SARS-CoV-2 infection and vaccination
- (2022) Katharina Röltgen et al. CELL
- Considerable escape of SARS-CoV-2 Omicron to antibody neutralization
- (2022) Delphine Planas et al. NATURE
- Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization
- (2022) Sandile Cele et al. NATURE
- SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters
- (2022) Peter J. Halfmann et al. NATURE
- A Fc-enhanced NTD-binding non-neutralizing antibody delays virus spread and synergizes with a nAb to protect mice from lethal SARS-CoV-2 infection
- (2022) Guillaume Beaudoin-Bussières et al. Cell Reports
- Neutralization of SARS-CoV-2 Omicron sub-lineages BA.1, BA.1.1, and BA.2
- (2022) John P. Evans et al. Cell Host & Microbe
- Pan-coronavirus vaccine pipeline takes form
- (2022) Elie Dolgin NATURE REVIEWS DRUG DISCOVERY
- Neutralization of the SARS-CoV-2 Deltacron and BA.3 Variants
- (2022) John P. Evans et al. NEW ENGLAND JOURNAL OF MEDICINE
- Multimericity Amplifies the Synergy of BCR and TLR4 for B Cell Activation and Antibody Class Switching
- (2022) Egest J. Pone et al. Frontiers in Immunology
- Omicron BA.1 breakthrough infection drives cross-variant neutralization and memory B cell formation against conserved epitopes
- (2022) Jasmin Quandt et al. Science Immunology
- BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection
- (2022) Yunlong Cao et al. NATURE
- Neutralization of the SARS-CoV-2 Omicron BA.4/5 and BA.2.12.1 Subvariants
- (2022) Panke Qu et al. NEW ENGLAND JOURNAL OF MEDICINE
- Mosaic RBD nanoparticles protect against challenge by diverse sarbecoviruses in animal models
- (2022) Alexander A. Cohen et al. SCIENCE
- Broadly neutralizing antibodies target the coronavirus fusion peptide
- (2022) Cherrelle Dacon et al. SCIENCE
- ACE2-binding exposes the SARS-CoV-2 fusion peptide to broadly neutralizing coronavirus antibodies
- (2022) Jun Siong Low et al. SCIENCE
- Pathogenicity, transmissibility, and fitness of SARS-CoV-2 Omicron in Syrian hamsters
- (2022) Shuofeng Yuan et al. SCIENCE
- A live-attenuated SARS-CoV-2 vaccine candidate with accessory protein deletions
- (2022) Yang Liu et al. Nature Communications
- Respiratory mucosal immunity against SARS-CoV-2 following mRNA vaccination
- (2022) Jinyi Tang et al. Science Immunology
- Safety, immunogenicity and antibody persistence of a bivalent Beta-containing booster vaccine against COVID-19: a phase 2/3 trial
- (2022) Spyros Chalkias et al. NATURE MEDICINE
- Bivalent SARS-CoV-2 mRNA vaccines increase breadth of neutralization and protect against the BA.5 Omicron variant in mice
- (2022) Suzanne M. Scheaffer et al. NATURE MEDICINE
- A Bivalent Omicron-Containing Booster Vaccine against Covid-19
- (2022) Spyros Chalkias et al. NEW ENGLAND JOURNAL OF MEDICINE
- Anti-Spike Mucosal IgA Protection against SARS-CoV-2 Omicron Infection
- (2022) Sebastian Havervall et al. NEW ENGLAND JOURNAL OF MEDICINE
- Durability of Booster mRNA Vaccine against SARS-CoV-2 BA.2.12.1, BA.4, and BA.5 Subvariants
- (2022) Panke Qu et al. NEW ENGLAND JOURNAL OF MEDICINE
- Unadjuvanted intranasal spike vaccine elicits protective mucosal immunity against sarbecoviruses
- (2022) Tianyang Mao et al. SCIENCE
- Imprinted antibody responses against SARS-CoV-2 Omicron sublineages
- (2022) Young-Jun Park et al. SCIENCE
- SARS-CoV-2 vaccination induces mucosal antibody responses in previously infected individuals
- (2022) Kaori Sano et al. Nature Communications
- Household transmission of SARS-CoV-2 Omicron variant of concern subvariants BA.1 and BA.2 in Denmark
- (2022) Frederik Plesner Lyngse et al. Nature Communications
- SARS-CoV-2 infections elicit higher levels of original antigenic sin antibodies compared with SARS-CoV-2 mRNA vaccinations
- (2022) Elizabeth M. Anderson et al. Cell Reports
- Enhanced neutralization resistance of SARS-CoV-2 Omicron subvariants BQ.1, BQ.1.1, BA.4.6, BF.7, and BA.2.75.2
- (2022) Panke Qu et al. Cell Host & Microbe
- Effect of hybrid immunity and bivalent booster vaccination on omicron sublineage neutralisation
- (2022) Markus Hoffmann et al. LANCET INFECTIOUS DISEASES
- Low neutralization of SARS-CoV-2 Omicron BA.2.75.2, BQ.1.1 and XBB.1 by parental mRNA vaccine or a BA.5 bivalent booster
- (2022) Chaitanya Kurhade et al. NATURE MEDICINE
- Neutralization against BA.2.75.2, BQ.1.1, and XBB from mRNA Bivalent Booster
- (2022) Meredith E. Davis-Gardner et al. NEW ENGLAND JOURNAL OF MEDICINE
- Capsid-like particles decorated with the SARS-CoV-2 receptor-binding domain elicit strong virus neutralization activity
- (2021) Cyrielle Fougeroux et al. Nature Communications
- SARS-CoV-2 spike D614G change enhances replication and transmission
- (2021) Bin Zhou et al. NATURE
- Neutralizing and protective human monoclonal antibodies recognizing the N-terminal domain of the SARS-CoV-2 spike protein
- (2021) Naveenchandra Suryadevara et al. CELL
- Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection
- (2021) David S. Khoury et al. NATURE MEDICINE
- Efficacy of NVX-CoV2373 Covid-19 Vaccine against the B.1.351 Variant
- (2021) Vivek Shinde et al. NEW ENGLAND JOURNAL OF MEDICINE
- Protection against SARS-CoV-2 infection by a mucosal vaccine in rhesus macaques
- (2021) Yongjun Sui et al. JCI Insight
- Live imaging of SARS-CoV-2 infection in mice reveals that neutralizing antibodies require Fc function for optimal efficacy
- (2021) Irfan Ullah et al. IMMUNITY
- Fc-engineered antibody therapeutics with improved anti-SARS-CoV-2 efficacy
- (2021) Rachel Yamin et al. NATURE
- Reduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization
- (2021) Delphine Planas et al. NATURE
- Original antigenic sin responses to Betacoronavirus spike proteins are observed in a mouse model, but are not apparent in children following SARS-CoV-2 infection
- (2021) Stacey A. Lapp et al. PLoS One
- Efficacy and breadth of adjuvanted SARS-CoV-2 receptor-binding domain nanoparticle vaccine in macaques
- (2021) Hannah A. D. King et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Scalable live-attenuated SARS-CoV-2 vaccine candidate demonstrates preclinical safety and efficacy
- (2021) Ying Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Broad betacoronavirus neutralization by a stem helix–specific human antibody
- (2021) Dora Pinto et al. SCIENCE
- Intranasal ChAdOx1 nCoV-19/AZD1222 vaccination reduces viral shedding after SARS-CoV-2 D614G challenge in preclinical models
- (2021) Neeltje van Doremalen et al. Science Translational Medicine
- Immune imprinting and SARS-CoV-2 vaccine design
- (2021) Adam K. Wheatley et al. TRENDS IN IMMUNOLOGY
- Immunological imprinting of the antibody response in COVID-19 patients
- (2021) Teresa Aydillo et al. Nature Communications
- Development of safe and highly protective live-attenuated SARS-CoV-2 vaccine candidates by genome recoding
- (2021) Jakob Trimpert et al. Cell Reports
- Discovery of ultrapotent broadly neutralizing antibodies from SARS-CoV-2 elite neutralizers
- (2021) Kanika Vanshylla et al. Cell Host & Microbe
- Protective mucosal immunity against SARS-CoV-2 after heterologous systemic prime-mucosal boost immunization
- (2021) Dennis Lapuente et al. Nature Communications
- SARS-CoV-2 ferritin nanoparticle vaccines elicit broad SARS coronavirus immunogenicity
- (2021) M. Gordon Joyce et al. Cell Reports
- Live attenuated virus vaccine protects against SARS-CoV-2 variants of concern B.1.1.7 (Alpha) and B.1.351 (Beta)
- (2021) Jakob Trimpert et al. Science Advances
- Current and future nanoparticle vaccines for COVID-19
- (2021) Mai N. Vu et al. EBioMedicine
- Original Antigenic Sin: How Original? How Sinful?
- (2020) Jonathan W. Yewdell et al. Cold Spring Harbor Perspectives in Medicine
- Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein
- (2020) Alexandra C. Walls et al. CELL
- DNA vaccine protection against SARS-CoV-2 in rhesus macaques
- (2020) Jingyou Yu et al. SCIENCE
- Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus
- (2020) Bette Korber et al. CELL
- Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques
- (2020) Noe B. Mercado et al. NATURE
- Loss of Bcl-6-Expressing T Follicular Helper Cells and Germinal Centers in COVID-19
- (2020) Naoki Kaneko et al. CELL
- Neutralizing Antibodies Correlate with Protection from SARS-CoV-2 in Humans during a Fishery Vessel Outbreak with a High Attack Rate
- (2020) Amin Addetia et al. JOURNAL OF CLINICAL MICROBIOLOGY
- Spike mutation D614G alters SARS-CoV-2 fitness
- (2020) Jessica A. Plante et al. NATURE
- A platform incorporating trimeric antigens into self-assembling nanoparticles reveals SARS-CoV-2-spike nanoparticles to elicit substantially higher neutralizing responses than spike alone
- (2020) Baoshan Zhang et al. Scientific Reports
- Pathological changes in the lungs and lymphatic organs of twelve COVID-19 autopsy cases
- (2020) Qian Liu et al. National Science Review
- Cold-Adapted Live Attenuated SARS-Cov-2 Vaccine Completely Protects Human ACE2 Transgenic Mice from SARS-Cov-2 Infection
- (2020) Sang Heui Seo et al. Vaccines
- Antibody potency, effector function, and combinations in protection and therapy for SARS-CoV-2 infection in vivo
- (2020) Alexandra Schäfer et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Correlates of protection against SARS-CoV-2 in rhesus macaques
- (2020) Katherine McMahan et al. NATURE
- SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity
- (2020) Lizhou Zhang et al. Nature Communications
- Mucosal Immunity in COVID-19: A Neglected but Critical Aspect of SARS-CoV-2 Infection
- (2020) Michael W. Russell et al. Frontiers in Immunology
- Antibody Immunodominance: The Key to Understanding Influenza Virus Antigenic Drift
- (2018) Meghan O. Altman et al. VIRAL IMMUNOLOGY
- Polyvalent vaccines: High-maintenance heroes
- (2018) Barbara Schlingmann et al. PLoS Pathogens
- Reconstituted B cell receptor signaling reveals carbohydrate-dependent mode of activation
- (2016) Rina F. Villar et al. Scientific Reports
- B cell antigen receptors of the IgM and IgD classes are clustered in different protein islands that are altered during B cell activation
- (2015) Palash Chandra Maity et al. Science Signaling
- B cell antigen receptors of the IgM and IgD classes are clustered in different protein islands that are altered during B cell activation
- (2015) Palash Chandra Maity et al. Science Signaling
- Identification of human neutralizing antibodies against MERS-CoV and their role in virus adaptive evolution
- (2014) X.-C. Tang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- B cell activation involves nanoscale receptor reorganizations and inside-out signaling by Syk
- (2014) Kathrin Kläsener et al. eLife
- GP4-specific neutralizing antibodies might be a driving force in PRRSV evolution
- (2010) Sarah Costers et al. VIRUS RESEARCH
- Selection Pressure From Neutralizing Antibodies Drives Sequence Evolution During Acute Infection With Hepatitis C Virus
- (2009) Kimberly A. Dowd et al. GASTROENTEROLOGY
- Limited Neutralizing Antibody Specificities Drive Neutralization Escape in Early HIV-1 Subtype C Infection
- (2009) Penny L. Moore et al. PLoS Pathogens
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