IRE1α-JNK axis activation contributes to intracellular lipid accumulation in calf hepatocytes

Regulated IRE1α-dependent decay (RIDD)-mediated reprograming of lipid metabolism in cancer

(2022) Aitor Almanza et al.   Nature Communications

Targeting IRE1α and PERK in the endoplasmic reticulum stress pathway attenuates fatty acid-induced insulin resistance in bovine hepatocytes

(2022) Zhiyuan Fang et al.   JOURNAL OF DAIRY SCIENCE

Disruption of endoplasmic reticulum homeostasis exacerbates liver injury in clinically ketotic cows

(2021) Zhen Shi et al.   JOURNAL OF DAIRY SCIENCE

Reducing hepatic endoplasmic reticulum stress ameliorates the impairment in insulin signaling induced by high levels of β-hydroxybutyrate in bovine hepatocytes

(2021) Lin Lei et al.   JOURNAL OF DAIRY SCIENCE

CPT1A-mediated Fat Oxidation, Mechanisms, and Therapeutic Potential

(2020) Isabel R Schlaepfer et al.   ENDOCRINOLOGY

Non-esterified Fatty Acid Induce Dairy Cow Hepatocytes Apoptosis via the Mitochondria-Mediated ROS-JNK/ERK Signaling Pathway

(2020) Yu Li et al.   Frontiers in Cell and Developmental Biology

Fatty acid-induced endoplasmic reticulum stress promoted lipid accumulation in calf hepatocytes, and endoplasmic reticulum stress existed in the liver of severe fatty liver cows

(2019) Yiwei Zhu et al.   JOURNAL OF DAIRY SCIENCE

Low abundance of mitofusin 2 in dairy cows with moderate fatty liver is associated with alterations in hepatic lipid metabolism

(2019) Jihong Dong et al.   JOURNAL OF DAIRY SCIENCE

New insights into the role and mechanism of c-Jun-N-terminal kinase signaling in the pathobiology of liver diseases

(2018) Sanda Win et al.   HEPATOLOGY

NEFA-induced ROS impaired insulin signalling through the JNK and p38MAPK pathways in non-alcoholic steatohepatitis

(2018) Wenwen Gao et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

High concentrations of fatty acids and β-hydroxybutyrate impair the growth hormone-mediated hepatic JAK2-STAT5 pathway in clinically ketotic cows

(2018) Xiliang Du et al.   JOURNAL OF DAIRY SCIENCE

Transcriptional changes detected in fecal RNA of neonatal dairy calves undergoing a mild diarrhea are associated with inflammatory biomarkers

(2018) Fernanda Rosa et al.   PLoS One

Acetoacetate induces hepatocytes apoptosis by the ROS-mediated MAPKs pathway in ketotic cows

(2017) Xiliang Du et al.   JOURNAL OF CELLULAR PHYSIOLOGY

JNK at the crossroad of obesity, insulin resistance, and cell stress response

(2017) Giovanni Solinas et al.   Molecular Metabolism

High levels of acetoacetate and glucose increase expression of cytokines in bovine hepatocytes, through activation of the NF-κB signalling pathway

(2016) Yu Li et al.   JOURNAL OF DAIRY RESEARCH

Allosteric Inhibition of the IRE1α RNase Preserves Cell Viability and Function during Endoplasmic Reticulum Stress

(2014) Rajarshi Ghosh et al.   CELL

Periostin promotes liver steatosis and hypertriglyceridemia through downregulation of PPARα

(2014) Yan Lu et al.   JOURNAL OF CLINICAL INVESTIGATION

Increased expression of c-Jun in nonalcoholic fatty liver disease

(2014) Christoph Dorn et al.   LABORATORY INVESTIGATION

Phosphorylation of sterol regulatory element-binding protein (SREBP)-1c by p38 kinases, ERK and JNK influences lipid metabolism and the secretome of human liver cell line HepG2

(2014) Birgit Knebel et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

A novel JNK2/SREBP-1c pathway involved in insulin-induced fatty acid synthesis in human adipocytes

(2013) Minoru Ito et al.   JOURNAL OF LIPID RESEARCH

Fatty acid-mediated endoplasmic reticulum stress in vivo: Differential response to the infusion of Soybean and Lard Oil in rats

(2013) Angela M. Nivala et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Silencing of Lipid Metabolism Genes through IRE1α-Mediated mRNA Decay Lowers Plasma Lipids in Mice

(2012) Jae-Seon So et al.   Cell Metabolism

A Liver Full of JNK: Signaling in Regulation of Cell Function and Disease Pathogenesis, and Clinical Approaches

(2012) Ekihiro Seki et al.   GASTROENTEROLOGY

Hepatic Deficiency in Transcriptional Cofactor TBL1 Promotes Liver Steatosis and Hypertriglyceridemia

(2011) Philipp Kulozik et al.   Cell Metabolism

Functional significance of the two ACOX1 isoforms and their crosstalks with PPARα and RXRα

(2010) Aurore Vluggens et al.   LABORATORY INVESTIGATION

JNK regulation of hepatic manifestations of the metabolic syndrome

(2010) Mark J. Czaja   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Hepatocyte-Specific Deletion of SIRT1 Alters Fatty Acid Metabolism and Results in Hepatic Steatosis and Inflammation

(2009) Aparna Purushotham et al.   Cell Metabolism

Protective effects of SP600125 in a diet-induced rat model of non-alcoholic steatohepatitis

(2009) Ying-Bin Hu et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Reduction of JNK1 expression with antisense oligonucleotide improves adiposity in obese mice

(2008) Xing Xian Yu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

SREBPs: physiology and pathophysiology of the SREBP family

(2008) Hitoshi Shimano   FEBS Journal

Differential effects of JNK1 and JNK2 inhibition on murine steatohepatitis and insulin resistance

(2008) Rajat Singh et al.   HEPATOLOGY

Regulation of Hepatic Lipogenesis by the Transcription Factor XBP1

(2008) A.-H. Lee et al.   SCIENCE