Periostin promotes liver steatosis and hypertriglyceridemia through downregulation of PPARα

Activation of PPAR  Ameliorates Hepatic Insulin Resistance and Steatosis in High Fructose-Fed Mice Despite Increased Endoplasmic Reticulum Stress

(2013) S. M. H. Chan et al.   DIABETES

Yin Yang 1 promotes hepatic steatosis through repression of farnesoid X receptor in obese mice

(2013) Yan Lu et al.   GUT

Irisin is inversely associated with intrahepatic triglyceride contents in obese adults

(2013) Hui-Jie Zhang et al.   JOURNAL OF HEPATOLOGY

Hepatic steatosis exacerbated by endoplasmic reticulum stress-mediated downregulation of FXR in aging mice

(2013) Xuelian Xiong et al.   JOURNAL OF HEPATOLOGY

The role of hepatokines in metabolism

(2013) Norbert Stefan et al.   Nature Reviews Endocrinology

Progression of NAFLD to diabetes mellitus, cardiovascular disease or cirrhosis

(2013) Quentin M. Anstee et al.   Nature Reviews Gastroenterology & Hepatology

A Liver Full of JNK: Signaling in Regulation of Cell Function and Disease Pathogenesis, and Clinical Approaches

(2012) Ekihiro Seki et al.   GASTROENTEROLOGY

The lipogenic transcription factor ChREBP dissociates hepatic steatosis from insulin resistance in mice and humans

(2012) Fadila Benhamed et al.   JOURNAL OF CLINICAL INVESTIGATION

The multiple facets of periostin in bone metabolism

(2012) B. Merle et al.   OSTEOPOROSIS INTERNATIONAL

Misregulation of PPAR Functioning and Its Pathogenic Consequences Associated with Nonalcoholic Fatty Liver Disease in Human Obesity

(2012) Luis A. Videla et al.   PPAR Research

Hepatic Deficiency in Transcriptional Cofactor TBL1 Promotes Liver Steatosis and Hypertriglyceridemia

(2011) Philipp Kulozik et al.   Cell Metabolism

Glucose-Mediated Repression of Menin Promotes Pancreatic β-Cell Proliferation

(2011) Hongli Zhang et al.   ENDOCRINOLOGY

Pancreatic-derived factor promotes lipogenesis in the mouse liver: Role of the Forkhead box 1 signaling pathway

(2011) Jing Li et al.   HEPATOLOGY

Retinoic acid receptor-related orphan receptor α-induced activation of adenosine monophosphate-activated protein kinase results in attenuation of hepatic steatosis

(2011) Eun-Jin Kim et al.   HEPATOLOGY

Inhibition of c-Jun-N-terminal Kinase Increases Cardiac Peroxisome Proliferator-activated Receptor α Expression and Fatty Acid Oxidation and Prevents Lipopolysaccharide-induced Heart Dysfunction

(2011) Konstantinos Drosatos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ChREBP Mediates Glucose Repression of Peroxisome Proliferator-activated Receptor α Expression in Pancreatic β-Cells

(2011) Michael Boergesen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cdc42 and Rac1 are major contributors to the saturated fatty acid-stimulated JNK pathway in hepatocytes

(2011) Manju Sharma et al.   JOURNAL OF HEPATOLOGY

Genetic determinants of hepatic steatosis in man

(2011) Amanda J. Hooper et al.   JOURNAL OF LIPID RESEARCH

Interactions between cancer stem cells and their niche govern metastatic colonization

(2011) Ilaria Malanchi et al.   NATURE

Human Fatty Liver Disease: Old Questions and New Insights

(2011) J. C. Cohen et al.   SCIENCE

Periostin, a Cell Adhesion Molecule, Facilitates Invasion in the Tumor Microenvironment and Annotates a Novel Tumor-Invasive Signature in Esophageal Cancer

(2010) C. Z. Michaylira et al.   CANCER RESEARCH

Increased Fibroblast Growth Factor 21 in Obesity and Nonalcoholic Fatty Liver Disease

(2010) Jody Dushay et al.   GASTROENTEROLOGY

Fenofibrate Increases Very Low Density Lipoprotein Triglyceride Production Despite Reducing Plasma Triglyceride Levels in APOE*3-Leiden.CETP Mice

(2010) Silvia Bijland et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deletion of steroid receptor coactivator-3 gene ameliorates hepatic steatosis

(2010) Xinran Ma et al.   JOURNAL OF HEPATOLOGY

PPARα: an emerging therapeutic target in diabetic microvascular damage

(2010) Anne Hiukka et al.   Nature Reviews Endocrinology

Animal models of nonalcoholic fatty liver disease

(2010) Lionel Hebbard et al.   Nature Reviews Gastroenterology & Hepatology

JNK regulation of hepatic manifestations of the metabolic syndrome

(2010) Mark J. Czaja   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Upregulated expression of periostin by hypoxia in non-small-cell lung cancer cells promotes cell survival via the Akt/PKB pathway

(2009) Gaoliang Ouyang et al.   CANCER LETTERS

Hepatocyte-Specific Deletion of SIRT1 Alters Fatty Acid Metabolism and Results in Hepatic Steatosis and Inflammation

(2009) Aparna Purushotham et al.   Cell Metabolism

The multifaceted role of periostin in tumorigenesis

(2009) Kai Ruan et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Obesity and nonalcoholic fatty liver disease: Biochemical, metabolic, and clinical implications

(2009) Elisa Fabbrini et al.   HEPATOLOGY

Association between PPARGC1A polymorphisms and the occurrence of nonalcoholic fatty liver disease (NAFLD)

(2008) Masato Yoneda et al.   BMC GASTROENTEROLOGY

Genome-wide Coactivation Analysis of PGC-1α Identifies BAF60a as a Regulator of Hepatic Lipid Metabolism

(2008) Siming Li et al.   Cell Metabolism

Differential effects of JNK1 and JNK2 inhibition on murine steatohepatitis and insulin resistance

(2008) Rajat Singh et al.   HEPATOLOGY

Fetuin-A and Its Relation to Metabolic Syndrome and Fatty Liver Disease in Obese Children Before and After Weight Loss

(2008) Thomas Reinehr et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice

(2008) Catherine Postic et al.   JOURNAL OF CLINICAL INVESTIGATION

A Val227Ala substitution in the peroxisome proliferator activated receptor alpha (PPAR alpha) gene associated with non-alcoholic fatty liver disease and decreased waist circumference and waist-to-hip ratio

(2008) Shaohua Chen et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

The nuclear receptor CAR (NR1I3) regulates serum triglyceride levels under conditions of metabolic stress

(2008) Jodi M. Maglich et al.   JOURNAL OF LIPID RESEARCH