Engineered short forms of perlecan enhance angiogenesis by potentiating growth factor signalling

Recombinant perlecan domain V covalently immobilized on silk biomaterials via plasma immersion ion implantation supports the formation of functional endothelium

(2023) Kieran Lau et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Conditional expression of endorepellin in the tumor vasculature attenuates breast cancer growth, angiogenesis and hyaluronan deposition

(2023) Carolyn G. Chen et al.   MATRIX BIOLOGY

Macrophages bind LDL using heparan sulfate and the perlecan protein core

(2021) Chun-yi Ng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chitosan-Based Functional Materials for Skin Wound Repair: Mechanisms and Applications

(2021) Peipei Feng et al.   Frontiers in Bioengineering and Biotechnology

Ice Templating Soft Matter: Fundamental Principles and Fabrication Approaches to Tailor Pore Structure and Morphology and Their Biomedical Applications

(2021) Habib Joukhdar et al.   ADVANCED MATERIALS

Vascularization strategies in tissue engineering approaches for soft tissue repair

(2021) Daniela Santos Masson‐Meyers et al.   Journal of Tissue Engineering and Regenerative Medicine

Bioactive extracellular matrix scaffolds engineered with proangiogenic proteoglycan mimetics and loaded with endothelial progenitor cells promote neovascularization and diabetic wound healing

(2021) Siqi He et al.   Bioactive Materials

Growth Factor Engineering Strategies for Regenerative Medicine Applications

(2020) Xiaochen Ren et al.   Frontiers in Bioengineering and Biotechnology

Experimental models and methods for cutaneous wound healing assessment

(2020) Daniela S. Masson-Meyers et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

A Biomimetic Approach toward Enhancing Angiogenesis: Recombinantly Expressed Domain V of Human Perlecan Is a Bioactive Molecule That Promotes Angiogenesis and Vascularization of Implanted Biomaterials

(2020) Xiaoting Lin et al.   Advanced Science

Fabrication and Investigation of the Suitability of Chitosan-Silver Composite Scaffolds for Bone Tissue Engineering Applications

(2020) Baskaran Vaidhyanathan et al.   PROCESS BIOCHEMISTRY

Growth factors with enhanced syndecan binding generate tonic signalling and promote tissue healing

(2019) Mayumi Mochizuki et al.   Nature Biomedical Engineering

Reactivity-driven cleanup of 2-Aminobenzamide derivatized oligosaccharides

(2018) An-Hsiang Adam Chu et al.   ANALYTICAL BIOCHEMISTRY

Tissue clearing of both hard and soft tissue organs with the PEGASOS method

(2018) Dian Jing et al.   CELL RESEARCH

Perlecan and vascular endothelial growth factor-encoding DNA-loaded chitosan scaffolds promote angiogenesis and wound healing

(2017) Megan S. Lord et al.   JOURNAL OF CONTROLLED RELEASE

Glycosaminoglycan and Proteoglycan-Based Biomaterials: Current Trends and Future Perspectives

(2017) Jelena Rnjak-Kovacina et al.   Advanced Healthcare Materials

Diabetic Foot Ulcers and Epidermal Growth Factor: Revisiting the Local Delivery Route for a Successful Outcome

(2017) Jorge Berlanga-Acosta et al.   Biomed Research International

Recombinant Domain V of Human Perlecan Is a Bioactive Vascular Proteoglycan

(2017) Jelena Rnjak-Kovacina et al.   Biotechnology Journal

Accelerated wound healing in a diabetic rat model using decellularized dermal matrix and human umbilical cord perivascular cells

(2016) P. Brouki Milan et al.   Acta Biomaterialia

Silk biomaterials functionalized with recombinant domain V of human perlecan modulate endothelial cell and platelet interactions for vascular applications

(2016) Jelena Rnjak-Kovacina et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

The I-TASSER Suite: protein structure and function prediction

(2015) Jianyi Yang et al.   NATURE METHODS

The role of vascular-derived perlecan in modulating cell adhesion, proliferation and growth factor signaling

(2014) Megan S. Lord et al.   MATRIX BIOLOGY

Growth Factors Engineered for Super-Affinity to the Extracellular Matrix Enhance Tissue Healing

(2014) M. M. Martino et al.   SCIENCE

The regenerative potential of fibroblasts in a new diabetes-induced delayed humanised wound healing model

(2013) Lucía Martínez-Santamaría et al.   EXPERIMENTAL DERMATOLOGY

Recombinant production of proteoglycans and their bioactive domains

(2013) Megan S. Lord et al.   FEBS Journal

Mast Cells Produce Novel Shorter Forms of Perlecan That Contain Functional Endorepellin

(2012) MoonSun Jung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chitosan preparations for wounds and burns: antimicrobial and wound-healing effects

(2011) Tianhong Dai et al.   Expert Review of Anti-Infective Therapy

Colocalization in vivo and association in vitro of perlecan and elastin

(2011) Anthony J. Hayes et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Human pilot studies reveal the potential of a vitronectin: growth factor complex as a treatment for chronic wounds

(2011) Zee Upton et al.   International Wound Journal

Heparan Sulfate-Dependent Signaling of Fibroblast Growth Factor 18 by Chondrocyte-Derived Perlecan

(2010) Christine Y. Chuang et al.   BIOCHEMISTRY

The healing of full-thickness burns treated by using plasmid DNA encoding VEGF-165 activated collagen–chitosan dermal equivalents

(2010) Rui Guo et al.   BIOMATERIALS

Soluble Perlecan Domain I Enhances Vascular Endothelial Growth Factor-165 Activity and Receptor Phosphorylation in Human Bone Marrow Endothelial Cells

(2010) Arivalagan Muthusamy et al.   BMC BIOCHEMISTRY

Benefit-Risk Assessment of Becaplermin in the Treatment of Diabetic Foot Ulcers

(2010) Nikolaos Papanas et al.   DRUG SAFETY

I-TASSER: a unified platform for automated protein structure and function prediction

(2010) Ambrish Roy et al.   Nature Protocols

Perlecan regulates developmental angiogenesis by modulating the VEGF-VEGFR2 axis

(2009) Jason J. Zoeller et al.   MATRIX BIOLOGY

I-TASSER server for protein 3D structure prediction

(2008) Yang Zhang   BMC BIOINFORMATICS

Recombinant heparan sulfate for use in tissue engineering applications

(2008) John Whitelock et al.   JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY

Novel interactions of perlecan: Unraveling perlecan's role in angiogenesis

(2008) Gregory Bix et al.   MICROSCOPY RESEARCH AND TECHNIQUE