Complement C3 as a potential drug target in periodontitis: Evidence from the cis‐Mendelian randomization approach

Compstatins: the dawn of clinical C3-targeted complement inhibition

(2022) Christina Lamers et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

A genome-wide association study of serum proteins reveals shared loci with common diseases

(2022) Alexander Gudjonsson et al.   Nature Communications

C3-targeted host-modulation approaches to oral inflammatory conditions

(2022) Tetsuhiro Kajikawa et al.   SEMINARS IN IMMUNOLOGY

Estimation of causal effects of a time-varying exposure at multiple time points through multivariable mendelian randomization

(2022) Eleanor Sanderson et al.   PLoS Genetics

Host Modulation and Treatment of Periodontal Disease

(2021) M.G. Balta et al.   JOURNAL OF DENTAL RESEARCH

Integrating genomics with biomarkers and therapeutic targets to invigorate cardiovascular drug development

(2021) Michael V. Holmes et al.   Nature Reviews Cardiology

C3-targeted therapy in periodontal disease: moving closer to the clinic

(2021) George Hajishengallis et al.   TRENDS IN IMMUNOLOGY

Mendelian Randomization: Concepts and Scope

(2021) Rebecca C. Richmond et al.   Cold Spring Harbor Perspectives in Medicine

Treatment of Stage I‐III Periodontitis – The EFP S3 Level Clinical Practice Guideline

(2020) Mariano Sanz et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

Genetic drug target validation using Mendelian randomisation

(2020) Amand F. Schmidt et al.   Nature Communications

PhenoScanner V2: an expanded tool for searching human genotype–phenotype associations

(2019) Mihir A Kamat et al.   BIOINFORMATICS

Clinical promise of next-generation complement therapeutics

(2019) Dimitrios C. Mastellos et al.   NATURE REVIEWS DRUG DISCOVERY

Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data

(2019) Dmitry Shungin et al.   Nature Communications

Inferring Causal Relationships Between Risk Factors and Outcomes from Genome-Wide Association Study Data

(2018) Stephen Burgess et al.   Annual Review of Genomics and Human Genetics

Staging and grading of periodontitis: Framework and proposal of a new classification and case definition

(2018) Maurizio S. Tonetti et al.   JOURNAL OF PERIODONTOLOGY

The oral microbiota: dynamic communities and host interactions

(2018) Richard J. Lamont et al.   NATURE REVIEWS MICROBIOLOGY

Safety and Efficacy of the Complement Inhibitor AMY-101 in a Natural Model of Periodontitis in Non-human Primates

(2017) Tetsuhiro Kajikawa et al.   Molecular Therapy-Methods & Clinical Development

Inhibition of pre-existing natural periodontitis in non-human primates by a locally administered peptide inhibitor of complement C3

(2016) Tomoki Maekawa et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

Complement in disease: a defence system turning offensive

(2016) Daniel Ricklin et al.   Nature Reviews Nephrology

Update on Prevalence of Periodontitis in Adults in the United States: NHANES 2009 to 2012

(2015) Paul I. Eke et al.   JOURNAL OF PERIODONTOLOGY

The support of human genetic evidence for approved drug indications

(2015) Matthew R Nelson et al.   NATURE GENETICS

Genetic and Intervention Studies Implicating Complement C3 as a Major Target for the Treatment of Periodontitis

(2014) T. Maekawa et al.   JOURNAL OF IMMUNOLOGY

Time to take periodontitis seriously

(2014) I. L. C. Chapple   BMJ-British Medical Journal

Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology

(2007) Debbie A. Lawlor et al.   STATISTICS IN MEDICINE