A unified DNA‐ and RNA‐based NGS strategy for the analysis of multiple types of variants at the dual nucleic acid level in solid tumors

Computational methods and translational applications for targeted next‐generation sequencing platforms

(2022) Anisha Luthra et al.   GENES CHROMOSOMES & CANCER

Reliability analysis of exonic-breakpoint fusions identified by DNA sequencing for predicting the efficacy of targeted therapy in non-small cell lung cancer

(2022) Weihua Li et al.   BMC Medicine

Targeted RNA sequencing for upfront analysis of actionable driver alterations in non-small cell lung cancer

(2022) Sofie Claerhout et al.   LUNG CANCER

A Large-Scale Prospective Concordance Study of Plasma- and Tissue-Based Next-Generation Targeted Sequencing for Advanced Non–Small Cell Lung Cancer (LC-SCRUM-Liquid)

(2022) Akira Sugimoto et al.   CLINICAL CANCER RESEARCH

Precision oncology for RET-related tumors

(2022) Antonella Verrienti et al.   Frontiers in Oncology

Predicting response to immune checkpoint blockade in NSCLC with tumour-only RNA-seq

(2022) John F. Markham et al.   BRITISH JOURNAL OF CANCER

HER2 Copy Number and Resistance Mechanisms in Patients with HER2-positive Advanced Gastric Cancer Receiving Initial Trastuzumab-based Therapy in JACOB Trial

(2022) Filippo Pietrantonio et al.   CLINICAL CANCER RESEARCH

Crizotinib in Patients With MET-Amplified NSCLC

(2021) D. Ross Camidge et al.   Journal of Thoracic Oncology

Molecular tests and target therapies in oncology: recommendations from the Italian workshop

(2021) Carmine Pinto et al.   Future Oncology

Molecular Alterations in Gastric Preneoplastic Lesions and Early Gastric Cancer

(2021) Serena Battista et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Phase 2 Study of Dabrafenib Plus Trametinib in Patients With BRAF V600E-Mutant Metastatic NSCLC: Updated 5-Year Survival Rates and Genomic Analysis

(2021) David Planchard et al.   Journal of Thoracic Oncology

Trastuzumab Deruxtecan in HER2-Mutant Non–Small-Cell Lung Cancer

(2021) Bob T. Li et al.   NEW ENGLAND JOURNAL OF MEDICINE

Validation of a Circulating Tumor DNA ‐Based Next‐Generation Sequencing Assay in a Cohort of Patients with Solid tumors: A Proposed Solution for Decentralized Plasma Testing

(2021) Wael Al Zoughbi et al.   ONCOLOGIST

Comprehensive analysis of oncogenic fusions in mismatch repair deficient colorectal carcinomas by sequential DNA and RNA next generation sequencing

(2021) Jing Wang et al.   Journal of Translational Medicine

Optimising fusion detection through sequential DNA and RNA molecular profiling of non-small cell lung cancer

(2021) David A. Moore et al.   LUNG CANCER

Reflex testing in non-small cell lung carcinoma using DNA- and RNA-based next-generation sequencing—a single-center experience

(2021) Martin Zacharias et al.   Translational Lung Cancer Research

Optimizing Mutation and Fusion Detection in NSCLC by Sequential DNA and RNA Sequencing

(2020) Danielle Cohen et al.   Journal of Thoracic Oncology

Sequencing Strategies for Fusion Gene Detection

(2020) Erin E. Heyer et al.   BIOESSAYS

Target-based genomic profiling of ctDNA from Chinese non-small cell lung cancer patients: a result of real-world data

(2020) Huijuan Chen et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Targeted RNA sequencing with touch imprint cytology samples for non‐small cell lung cancer patients

(2020) Katsutoshi Seto et al.   Thoracic Cancer

Next Generation Sequencing for Gene Fusion Analysis in Lung Cancer: A Literature Review

(2020) Rossella Bruno et al.   Diagnostics

Capmatinib in MET Exon 14–Mutated or MET-Amplified Non–Small-Cell Lung Cancer

(2020) Jürgen Wolf et al.   NEW ENGLAND JOURNAL OF MEDICINE

Combined targeted DNA and RNA sequencing of advanced NSCLC in routine molecular diagnostics: Analysis of the first 3,000 Heidelberg cases

(2019) Anna-Lena Volckmar et al.   INTERNATIONAL JOURNAL OF CANCER

Targeted RNA-Seq in Non–Small-Cell Lung Cancer

(2019) Lauren L. Ritterhouse   JOURNAL OF MOLECULAR DIAGNOSTICS

Diagnosis of fusion genes using targeted RNA sequencing

(2019) Erin E. Heyer et al.   Nature Communications

High yield of RNA sequencing for targetable kinase fusions in lung adenocarcinomas with no driver alteration detected by DNA sequencing and low tumor mutation burden

(2019) Ryma Benayed et al.   CLINICAL CANCER RESEARCH

DNA-Based versus RNA-Based Detection of MET Exon 14 Skipping Events in Lung Cancer

(2019) Kurtis D. Davies et al.   Journal of Thoracic Oncology

Detection of NTRK Fusions: Merits and Limitations of Current Diagnostic Platforms

(2019) James P. Solomon et al.   CANCER RESEARCH

NTRK fusion detection across multiple assays and 33,997 cases: diagnostic implications and pitfalls

(2019) James P. Solomon et al.   MODERN PATHOLOGY

Utility of incorporating next-generation sequencing (NGS) in an Asian non-small cell lung cancer (NSCLC) population: Incremental yield of actionable alterations and cost-effectiveness analysis

(2019) Aaron C. Tan et al.   LUNG CANCER

Cost of cancer diagnosis using next-generation sequencing targeted gene panels in routine practice: a nationwide French study

(2018) Patricia Marino et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients

(2017) Ahmet Zehir et al.   NATURE MEDICINE

Prospective Comprehensive Molecular Characterization of Lung Adenocarcinomas for Efficient Patient Matching to Approved and Emerging Therapies

(2017) Emmet J. Jordan et al.   Cancer Discovery

Clinical Validation and Implementation of a Targeted Next-Generation Sequencing Assay to Detect Somatic Variants in Non-Small Cell Lung, Melanoma, and Gastrointestinal Malignancies

(2016) Kevin E. Fisher et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Clinical Applications of Next-Generation Sequencing in Cancer Diagnosis

(2016) Leila Sabour et al.   PATHOLOGY & ONCOLOGY RESEARCH

The prevalence of EGFR mutation in patients with non-small cell lung cancer: a systematic review and meta-analysis

(2016) Yue-Lun Zhang et al.   Oncotarget

Broad, Hybrid Capture-Based Next-Generation Sequencing Identifies Actionable Genomic Alterations in Lung Adenocarcinomas Otherwise Negative for Such Alterations by Other Genomic Testing Approaches

(2015) A. Drilon et al.   CLINICAL CANCER RESEARCH

MSIsensor: microsatellite instability detection using paired tumor-normal sequence data

(2013) Beifang Niu et al.   BIOINFORMATICS

VarScan 2: Somatic mutation and copy number alteration discovery in cancer by exome sequencing

(2012) D. C. Koboldt et al.   GENOME RESEARCH

The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data

(2010) A. McKenna et al.   GENOME RESEARCH

Fast and accurate short read alignment with Burrows-Wheeler transform

(2009) H. Li et al.   BIOINFORMATICS