Next Generation Sequencing for Gene Fusion Analysis in Lung Cancer: A Literature Review

State-of-the-Art Strategies for Targeting RET-Dependent Cancers

(2020) Vivek Subbiah et al.   JOURNAL OF CLINICAL ONCOLOGY

Optimizing Mutation and Fusion Detection in NSCLC by Sequential DNA and RNA Sequencing

(2020) Danielle Cohen et al.   Journal of Thoracic Oncology

Multiplexed molecular profiling of lung cancer with malignant pleural effusion using next generation sequencing in Chinese patients

(2020) Xingya Ruan et al.   Oncology Letters

Sequencing Strategies for Fusion Gene Detection

(2020) Erin E. Heyer et al.   BIOESSAYS

Next-Generation Sequencing in High-Sensitive Detection of Mutations in Tumors: Challenges, Advances and Applications

(2020) Rajesh R. Singh   JOURNAL OF MOLECULAR DIAGNOSTICS

A novel SOS1-ALK fusion variant in a patient with metastatic lung adenocarcinoma and a remarkable response to crizotinib

(2020) Hua-fei Chen et al.   LUNG CANCER

Is tissue still the issue in detecting molecular alterations in lung cancer?

(2020) Chong‐Kin Liam et al.   RESPIROLOGY

Selpercatinib: First Approval

(2020) Anthony Markham   DRUGS

Feasibility and clinical utility of a pan-solid tumor targeted RNA fusion panel: A single center experience

(2020) Issa Hindi et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Combined targeted DNA and RNA sequencing of advanced NSCLC in routine molecular diagnostics: Analysis of the first 3,000 Heidelberg cases

(2019) Anna-Lena Volckmar et al.   INTERNATIONAL JOURNAL OF CANCER

Diagnosis of fusion genes using targeted RNA sequencing

(2019) Erin E. Heyer et al.   Nature Communications

Efficient ten-gene analysis of NSCLC tissue samples by next-generation sequencing

(2019) Xiuhuan Ji et al.   PATHOLOGY RESEARCH AND PRACTICE

Next-Generation Sequencing for Genotyping of Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration Samples in Lung Cancer

(2019) Fangfang Xie et al.   ANNALS OF THORACIC SURGERY

Performance of Oncomine Fusion Transcript kit for formalin‐fixed, paraffin‐embedded lung cancer specimens

(2019) Kazuko Sakai et al.   CANCER SCIENCE

Clinical Utility of Comprehensive Cell-free DNA Analysis to Identify Genomic Biomarkers in Patients with Newly Diagnosed Metastatic Non–small Cell Lung Cancer

(2019) Natasha B. Leighl et al.   CLINICAL CANCER RESEARCH

High yield of RNA sequencing for targetable kinase fusions in lung adenocarcinomas with no driver alteration detected by DNA sequencing and low tumor mutation burden

(2019) Ryma Benayed et al.   CLINICAL CANCER RESEARCH

Advanced-Stage Non–Small Cell Lung Cancer: Advances in Thoracic Oncology 2018

(2019) Jordi Remon et al.   Journal of Thoracic Oncology

Methods for Identifying Patients with Tropomyosin Receptor Kinase (TRK) Fusion Cancer

(2019) Derek Wong et al.   PATHOLOGY & ONCOLOGY RESEARCH

An Integrated Next-Generation Sequencing System for Analyzing DNA Mutations, Gene Fusions, and RNA Expression in Lung Cancer

(2019) Brian C. Haynes et al.   Translational Oncology

Oncogenic Gene Fusion Detection Using Anchored Multiplex Polymerase Chain Reaction Followed by Next Generation Sequencing

(2019) Michael Seager et al.   Jove-Journal of Visualized Experiments

ROS1-ADGRG6: a case report of a novel ROS1 oncogenic fusion variant in lung adenocarcinoma and the response to crizotinib

(2019) Shuguang Xu et al.   BMC CANCER

Sensitivity of next-generation sequencing assays detecting oncogenic fusions in plasma cell-free DNA

(2019) Julianna G. Supplee et al.   LUNG CANCER

An Accurate and Comprehensive Clinical Sequencing Assay for Cancer Targeted and Immunotherapies

(2019) Jingyu Cao et al.   ONCOLOGIST

Quantitative detection of ALK fusion breakpoints in plasma cell-free DNA from patients with non-small cell lung cancer using PCR-based target sequencing with a tiling primer set and two-step mapping/alignment

(2019) Kei Kunimasa et al.   PLoS One

Identifying patients with NTRK fusion cancer

(2019) J P Solomon et al.   ANNALS OF ONCOLOGY

Targeted RNA‐sequencing assays: a step forward compared to FISH and IHC techniques?

(2019) Gaëlle Tachon et al.   Cancer Medicine

Simultaneous Detection of Gene Fusions and Base Mutations in Cancer Tissue Biopsies by Sequencing Dual Nucleic Acid Templates in Unified Reaction

(2019) Zhengbo Song et al.   CLINICAL CHEMISTRY

Clinical feasibility of NGS liquid biopsy analysis in NSCLC patients

(2019) Eirini Papadopoulou et al.   PLoS One

Analysis of Fusion Genes by NanoString System: A Role in Lung Cytology?

(2018) Greta Alì et al.   ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE

RNA Analysis as a Tool to Determine Clinically Relevant Gene Fusions and Splice Variants

(2018) Cristina Teixidó et al.   ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE

Updated Molecular Testing Guideline for the Selection of Lung Cancer Patients for Treatment With Targeted Tyrosine Kinase Inhibitors: Guideline From the College of American Pathologists, the International Association for the Study of Lung Cancer, and the Association for Molecular Pathology

(2018) Neal I. Lindeman et al.   ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE

Clinical Utility of Cell-Free DNA for the Detection ofALKFusions and Genomic Mechanisms of ALK Inhibitor Resistance in Non–Small Cell Lung Cancer

(2018) Caroline E. McCoach et al.   CLINICAL CANCER RESEARCH

GeneFuse: detection and visualization of target gene fusions from DNA sequencing data

(2018) Shifu Chen et al.   International Journal of Biological Sciences

Tearing down the walls: FDA approves next generation sequencing (NGS) assays for actionable cancer genomic aberrations

(2018) Matteo Allegretti et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Analytical Validation of a Hybrid Capture–Based Next-Generation Sequencing Clinical Assay for Genomic Profiling of Cell-Free Circulating Tumor DNA

(2018) Travis A. Clark et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Evaluation of NGS and RT-PCR Methods for ALK Rearrangement in European NSCLC Patients: Results from the European Thoracic Oncology Platform Lungscape Project

(2018) Igor Letovanec et al.   Journal of Thoracic Oncology

Comparison of molecular testing modalities for detection of ROS1 rearrangements in a cohort of positive patient samples

(2018) Kurtis D. Davies et al.   Journal of Thoracic Oncology

ALK fusion variants detection by targeted RNA-next generation sequencing and clinical responses to crizotinib in ALK-positive non-small cell lung cancer

(2018) Anne McLeer-Florin et al.   LUNG CANCER

Genomic heterogeneity of ALK fusion breakpoints in non-small-cell lung cancer

(2018) Jason N Rosenbaum et al.   MODERN PATHOLOGY

Evaluation of commercial DNA and RNA extraction methods for high-throughput sequencing of FFPE samples

(2018) Stine H. Kresse et al.   PLoS One

Analytical validation of a next generation sequencing liquid biopsy assay for high sensitivity broad molecular profiling

(2018) Vincent Plagnol et al.   PLoS One

SEGF: A Novel Method for Gene Fusion Detection from Single-End Next-Generation Sequencing Data

(2018) Hai Xu et al.   Genes

Simultaneous detection of lung fusions using a multiplex RT-PCR next generation sequencing-based approach: a multi-institutional research study

(2018) Cecily P. Vaughn et al.   BMC CANCER

Indel sensitive and comprehensive variant/mutation detection from RNA sequencing data for precision medicine

(2018) Naresh Prodduturi et al.   BMC Medical Genomics

Clinical utility of reflex testing using focused next-generation sequencing for management of patients with advanced lung adenocarcinoma

(2018) Tyler E Miller et al.   JOURNAL OF CLINICAL PATHOLOGY

Validation of the Oncomine™ focus panel for next-generation sequencing of clinical tumour samples

(2018) Hannah L. Williams et al.   VIRCHOWS ARCHIV

RNA-based analysis of ALK fusions in non-small cell lung cancer cases showing IHC/FISH discordance

(2018) Claudia Vollbrecht et al.   BMC CANCER

ALK testing methods: is there a winner or loser?

(2018) Yuka Kozuma et al.   Expert Review of Anticancer Therapy

Tumor clonality and resistance mechanisms in EGFR mutation-positive non-small-cell lung cancer: implications for therapeutic sequencing

(2018) Shinji Kohsaka et al.   Future Oncology

Rapid and highly-specific generation of targeted DNA sequencing libraries enabled by linking capture probes with universal primers

(2018) Joel Pel et al.   PLoS One

Exploratory analysis of introducing next-generation sequencing-based method to treatment-naive lung cancer patients

(2018) Yufang Feng et al.   Journal of Thoracic Disease

What do we need to make circulating tumour DNA (ctDNA) a routine diagnostic test in lung cancer?

(2017) Reyes Bernabé et al.   EUROPEAN JOURNAL OF CANCER

Targeting RET in Patients With RET-Rearranged Lung Cancers: Results From the Global, Multicenter RET Registry

(2017) Oliver Gautschi et al.   JOURNAL OF CLINICAL ONCOLOGY

Multiplexed transcriptome analysis to detect ALK, ROS1 and RET rearrangements in lung cancer

(2017) Toni-Maree Rogers et al.   Scientific Reports

Detection of known and novel ALK fusion transcripts in lung cancer patients using next-generation sequencing approaches

(2017) Julie A. Vendrell et al.   Scientific Reports

Precision medicine in NSCLC and pathology: how does ALK fit in the pathway?

(2016) K. M. Kerr et al.   ANNALS OF ONCOLOGY

NanoString, a novel digital color-coded barcode technology: current and future applications in molecular diagnostics

(2016) Hin-Fung Tsang et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Association Between Plasma Genotyping and Outcomes of Treatment With Osimertinib (AZD9291) in Advanced Non–Small-Cell Lung Cancer

(2016) Geoffrey R. Oxnard et al.   JOURNAL OF CLINICAL ONCOLOGY

Noninvasive genotyping and monitoring of anaplastic lymphoma kinase (ALK) rearranged non-small cell lung cancer by capture-based next-generation sequencing

(2016) Ye Wang et al.   Oncotarget

ALK FISH patterns and the detection of ALK fusions by next generation sequencing in lung adenocarcinoma

(2016) Sanja Dacic et al.   Oncotarget

High-throughput diagnostic profiling of clinically actionable gene fusions in lung cancer

(2015) Nicole Pfarr et al.   GENES CHROMOSOMES & CANCER

Fluorescence In Situ Hybridization, Immunohistochemistry, and Next-Generation Sequencing for Detection of EML4-ALK Rearrangement in Lung Cancer

(2015) M. Pekar-Zlotin et al.   ONCOLOGIST

Gefitinib Treatment in EGFR Mutated Caucasian NSCLC: Circulating-Free Tumor DNA as a Surrogate for Determination of EGFR Status

(2014) Jean-Yves Douillard et al.   Journal of Thoracic Oncology

The causes and consequences of genetic heterogeneity in cancer evolution

(2013) Rebecca A. Burrell et al.   NATURE

ROS1 Rearrangements Define a Unique Molecular Class of Lung Cancers

(2012) Kristin Bergethon et al.   JOURNAL OF CLINICAL ONCOLOGY