Regulatory effect of NK homeobox 1 (NKX2.1) on melanocortin 4 receptor (Mc4r) promoter in Mandarin fish

Effects and regulatory pathway of proopinmelanocortin on feeding habit domestication in mandarin fish

(2023) Hai-Lin Lu et al.   GENE

Possible role of transcription factors (BSX, NKX2.1, IRX3 and SIRT1) in the regulation of appetite in goldfish (Carassius auratus).

(2022) Kelsey R.T. Vinnicombe et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY

Improved Growth and High Inheritance of Melanocortin-4 Receptor (mc4r) Mutation in CRISPR/Cas-9 Gene-Edited Channel Catfish, Ictalurus punctatus

(2022) Michael Coogan et al.   MARINE BIOTECHNOLOGY

Molecular Analysis and Conformational Dynamics of Human MC4R Disease-Causing Mutations

(2022) Munazza Tamkeen Fatima et al.   MOLECULES

The melanocortin pathway and energy homeostasis: From discovery to obesity therapy

(2021) Giles S.H. Yeo et al.   Molecular Metabolism

Functional analysis of MTF-1 and MT promoters and their transcriptional response to zinc (Zn) and copper (Cu) in yellow catfish Pelteobagrus fulvidraco

(2020) Guang-Hui Chen et al.   CHEMOSPHERE

Melanocortin-4 receptor regulation of reproductive function in black rockfish (Sebastes schlegelii)

(2020) Ying Zhang et al.   GENE

Structural Complexity and Plasticity of Signaling Regulation at the Melanocortin-4 Receptor

(2020) Gunnar Kleinau et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mandarin fish (Sinipercidae) genomes provide insights into innate predatory feeding

(2020) Shan He et al.   Communications Biology

CpG Islands Shape the Epigenome Landscape

(2020) Christophe Papin et al.   JOURNAL OF MOLECULAR BIOLOGY

MC4R Signaling in Dorsal Raphe Nucleus Controls Feeding, Anxiety, and Depression

(2020) Giuseppe Bruschetta et al.   Cell Reports

Differential Roles of Two Leptin Gene Paralogues on Food Intake and Hepatic Metabolism Regulation in Mandarin Fish

(2020) Xiao-Chen Yuan et al.   Frontiers in Endocrinology

Functional Analysis of Steroidogenic Factor 1 (sf-1) and 17α-Hydroxylase/Lyase (cyp17α) Promoters in Yellow Catfish Pelteobagrus fulvidraco

(2020) Wu-Hong Lv et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Melanocortin-4 Receptor Signalling: Importance for Weight Regulation and Obesity Treatment

(2019) Peter Kühnen et al.   TRENDS IN MOLECULAR MEDICINE

The homeodomain transcription factor NKX2.1 is essential for the early specification of melanocortin neuron identity and activates Pomc expression in the developing hypothalamus

(2019) Daniela P. Orquera et al.   JOURNAL OF NEUROSCIENCE

Analysis of the Role of the Mc4r System in Development, Growth, and Puberty of Medaka

(2019) Ruiqi Liu et al.   Frontiers in Endocrinology

Organization and regulation of gene transcription

(2019) Patrick Cramer   NATURE

The degree of enhancer or promoter activity is reflected by the levels and directionality of eRNA transcription

(2018) Olga Mikhaylichenko et al.   GENES & DEVELOPMENT

MC4R agonism promotes durable weight loss in patients with leptin receptor deficiency

(2018) Karine Clément et al.   NATURE MEDICINE

MC4R Agonists: Structural Overview on Antiobesity Therapeutics

(2018) Juliana Pereira Lopes Gonçalves et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

POMC neurons expressing leptin receptors coordinate metabolic responses to fasting via suppression of leptin levels

(2018) Alexandre Caron et al.   eLife

Thyroid Hormone-Dependent Epigenetic Regulation of Melanocortin 4 Receptor Levels in Female Offspring of Obese Rats

(2017) Tzlil Tabachnik et al.   ENDOCRINOLOGY

Distal CpG islands can serve as alternative promoters to transcribe genes with silenced proximal promoters

(2017) Shrutii Sarda et al.   GENOME RESEARCH

Structure and Functional Analysis of Promoters from Two Liver Isoforms of CPT I in Grass Carp Ctenopharyngodon idella

(2017) Yi-Huan Xu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Regulation of feeding behavior and food intake by appetite-regulating peptides in wild-type and growth hormone-transgenic coho salmon

(2016) Samantha L. White et al.   HORMONES AND BEHAVIOR

Melanocortin-4 receptor–regulated energy homeostasis

(2016) Michael J Krashes et al.   NATURE NEUROSCIENCE

Melanocortin 4 receptor mutations contribute to the adaptation of cavefish to nutrient-poor conditions

(2015) Ariel C. Aspiras et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Leptin in teleostean fish, towards the origins of leptin physiology

(2014) Marnix Gorissen et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Analysis of nascent RNA identifies a unified architecture of initiation regions at mammalian promoters and enhancers

(2014) Leighton J Core et al.   NATURE GENETICS

Effects of Polymorphisms in Pepsinogen (PEP), Amylase (AMY) and Trypsin (TRY) Genes on Food Habit Domestication Traits in Mandarin Fish

(2013) Tilin Yi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Melanocortin 4 Receptor Becomes an ACTH Receptor by Coexpression of Melanocortin Receptor Accessory Protein 2

(2013) Maria Josep Agulleiro et al.   MOLECULAR ENDOCRINOLOGY

Energy balance regulation by thyroid hormones at central level

(2013) Miguel López et al.   TRENDS IN MOLECULAR MEDICINE

HSF is the Most Important Transcriptional Factor for PorcineMC4RPromoter

(2012) D. J. Zhang et al.   ANIMAL BIOTECHNOLOGY

Hypothalamic mTOR pathway mediates thyroid hormone-induced hyperphagia in hyperthyroidism

(2012) Luis Varela et al.   JOURNAL OF PATHOLOGY

Evolution of POMC: origin, phylogeny, posttranslational processing, and the melanocortins

(2011) Robert M. Dores et al.   Annals of the New York Academy of Sciences

NPY and MC4R Signaling Regulate Thyroid Hormone Levels during Fasting through Both Central and Peripheral Pathways

(2011) Kristen R. Vella et al.   Cell Metabolism

Thyroid Transcription Factor‐1 Regulates Feeding Behavior via Melanocortin Pathway in the Hypothalamus

(2011) Jae Geun Kim et al.   DIABETES

EGR1Is a Target for Cooperative Interactions between Cholecystokinin and Leptin, and Inhibition by Ghrelin, in Vagal Afferent Neurons

(2010) Guillaume de Lartigue et al.   ENDOCRINOLOGY

Gene expression in hypothalamus, liver, and adipose tissues and food intake response to melanocortin-4 receptor agonist in pigs expressing melanocortin-4 receptor mutations

(2010) C. Richard Barb et al.   PHYSIOLOGICAL GENOMICS

Thyroid hormone exerts negative feedback on hypothalamic type 4 melanocortin receptor expression

(2010) S. Decherf et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The incidence of co-morbidities related to obesity and overweight: A systematic review and meta-analysis

(2009) Daphne P Guh et al.   BMC PUBLIC HEALTH