Super-resolution microscopy: Insights into mitochondria–lysosome crosstalk in health and disease

STING signalling is terminated through ESCRT-dependent microautophagy of vesicles originating from recycling endosomes

(2023) Yoshihiko Kuchitsu et al.   NATURE CELL BIOLOGY

Misregulation of mitochondria–lysosome contact dynamics in Charcot–Marie–Tooth Type 2B disease Rab7 mutant sensory peripheral neurons

(2023) Yvette C. Wong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Parkin regulates amino acid homeostasis at mitochondria-lysosome (M/L) contact sites in Parkinson’s disease

(2023) Wesley Peng et al.   Science Advances

Technological advances in super-resolution microscopy to study cellular processes

(2022) Charles Bond et al.   MOLECULAR CELL

Mitochondria-lysosome contact site dynamics and misregulation in neurodegenerative diseases

(2022) Jasmine Cisneros et al.   TRENDS IN NEUROSCIENCES

Mid51/Fis1 mitochondrial oligomerization complex drives lysosomal untethering and network dynamics

(2022) Yvette C. Wong et al.   JOURNAL OF CELL BIOLOGY

Dominant mutations in MIEF1 affect mitochondrial dynamics and cause a singular late onset optic neuropathy

(2021) Majida Charif et al.   Molecular Neurodegeneration

Dysregulation of mitochondria-lysosome contacts by GBA1 dysfunction in dopaminergic neuronal models of Parkinson’s disease

(2021) Soojin Kim et al.   Nature Communications

Phase separation drives the self-assembly of mitochondrial nucleoids for transcriptional modulation

(2021) Qi Long et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mitochondria-lysosome contacts regulate mitochondrial Ca2+dynamics via lysosomal TRPML1

(2020) Wesley Peng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial RNA granules are fluid condensates positioned by membrane dynamics

(2020) Timo Rey et al.   NATURE CELL BIOLOGY

Late Endosomes Act as mRNA Translation Platforms and Sustain Mitochondria in Axons

(2019) Jean-Michel Cioni et al.   CELL

Lysosomal Regulation of Inter-mitochondrial Contact Fate and Motility in Charcot-Marie-Tooth Type 2

(2019) Yvette C. Wong et al.   DEVELOPMENTAL CELL

NPC1 regulates ER contacts with endocytic organelles to mediate cholesterol egress

(2019) D. Höglinger et al.   Nature Communications

Mitochondria–lysosome contacts regulate mitochondrial fission via RAB7 GTP hydrolysis

(2018) Yvette C. Wong et al.   NATURE

Visualizing Intracellular Organelle and Cytoskeletal Interactions at Nanoscale Resolution on Millisecond Timescales

(2018) Yuting Guo et al.   CELL

Cell-permeable organic fluorescent probes for live-cell long-term super-resolution imaging reveal lysosome-mitochondrion interactions

(2017) Yubing Han et al.   Nature Communications