Parkin regulates amino acid homeostasis at mitochondria-lysosome (M/L) contact sites in Parkinson’s disease

Mitochondria-lysosome contact site dynamics and misregulation in neurodegenerative diseases

(2022) Jasmine Cisneros et al.   TRENDS IN NEUROSCIENCES

Mid51/Fis1 mitochondrial oligomerization complex drives lysosomal untethering and network dynamics

(2022) Yvette C. Wong et al.   JOURNAL OF CELL BIOLOGY

Dysregulation of mitochondria-lysosome contacts by GBA1 dysfunction in dopaminergic neuronal models of Parkinson’s disease

(2021) Soojin Kim et al.   Nature Communications

MetaboAnalyst 5.0: narrowing the gap between raw spectra and functional insights

(2021) Zhiqiang Pang et al.   NUCLEIC ACIDS RESEARCH

Cysteine Toxicity Drives Age-Related Mitochondrial Decline by Altering Iron Homeostasis

(2020) Casey E. Hughes et al.   CELL

Mitochondria-lysosome contacts regulate mitochondrial Ca2+dynamics via lysosomal TRPML1

(2020) Wesley Peng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation and Function of Mitochondria–Lysosome Membrane Contact Sites in Cellular Homeostasis

(2019) Yvette C. Wong et al.   TRENDS IN CELL BIOLOGY

WebGestalt 2019: gene set analysis toolkit with revamped UIs and APIs

(2019) Yuxing Liao et al.   NUCLEIC ACIDS RESEARCH

Preserving Lysosomal Function in the Aging Brain: Insights from Neurodegeneration

(2019) Wesley Peng et al.   Neurotherapeutics

Lysosomal Regulation of Inter-mitochondrial Contact Fate and Motility in Charcot-Marie-Tooth Type 2

(2019) Yvette C. Wong et al.   DEVELOPMENTAL CELL

ER–lysosome contacts enable cholesterol sensing by mTORC1 and drive aberrant growth signalling in Niemann–Pick type C

(2019) Chun-Yan Lim et al.   NATURE CELL BIOLOGY

KEGG Mapper for inferring cellular functions from protein sequences

(2019) Minoru Kanehisa et al.   PROTEIN SCIENCE

A modulator of wild-type glucocerebrosidase improves pathogenic phenotypes in dopaminergic neuronal models of Parkinson’s disease

(2019) Lena F. Burbulla et al.   Science Translational Medicine

NPC1 regulates ER contacts with endocytic organelles to mediate cholesterol egress

(2019) D. Höglinger et al.   Nature Communications

Mitochondria–lysosome contacts regulate mitochondrial fission via RAB7 GTP hydrolysis

(2018) Yvette C. Wong et al.   NATURE

The multifaceted contributions of mitochondria to cellular metabolism

(2018) Jessica B. Spinelli et al.   NATURE CELL BIOLOGY

Quantitative Real-Time Imaging of Glutathione with Subcellular Resolution

(2018) Xiqian Jiang et al.   ANTIOXIDANTS & REDOX SIGNALING

Synaptic, Mitochondrial, and Lysosomal Dysfunction in Parkinson’s Disease

(2018) Maria Nguyen et al.   TRENDS IN NEUROSCIENCES

Lysosomal metabolomics reveals V-ATPase- and mTOR-dependent regulation of amino acid efflux from lysosomes

(2017) Monther Abu-Remaileh et al.   SCIENCE

Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson’s disease

(2017) Lena F. Burbulla et al.   SCIENCE

PINK1 Primes Parkin-Mediated Ubiquitination of PARIS in Dopaminergic Neuronal Survival

(2017) Yunjong Lee et al.   Cell Reports

Parkinson disease

(2017) Werner Poewe et al.   Nature Reviews Disease Primers

Absolute Quantification of Matrix Metabolites Reveals the Dynamics of Mitochondrial Metabolism

(2016) Walter W. Chen et al.   CELL

Parkin Modulates Endosomal Organization and Function of the Endo-Lysosomal Pathway

(2016) Pingping Song et al.   JOURNAL OF NEUROSCIENCE

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

Structure of Parkin Reveals Mechanisms for Ubiquitin Ligase Activation

(2013) J.-F. Trempe et al.   SCIENCE

Genetics of Parkinson's Disease

(2013) C. Klein et al.   Cold Spring Harbor Perspectives in Medicine

Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks

(2012) Cole Trapnell et al.   Nature Protocols

Amino acids and mTORC1: from lysosomes to disease

(2012) Alejo Efeyan et al.   TRENDS IN MOLECULAR MEDICINE

Structure-guided evolution of cyan fluorescent proteins towards a quantum yield of 93%

(2012) Joachim Goedhart et al.   Nature Communications

PARIS (ZNF746) Repression of PGC-1α Contributes to Neurodegeneration in Parkinson's Disease

(2011) Joo-Ho Shin et al.   CELL

Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson’s disease

(2011) Sonja Kriks et al.   NATURE

Predictors of Parkin Mutations in Early-Onset Parkinson Disease

(2010) Karen S. Marder et al.   ARCHIVES OF NEUROLOGY

Rubicon controls endosome maturation as a Rab7 effector

(2010) Q. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Rab7 Activation by Growth Factor Withdrawal Contributes to the Induction of Apoptosis

(2009) Kimberly Romero Rosales et al.   MOLECULAR BIOLOGY OF THE CELL

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

(2009) C. Vives-Bauza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY